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1. Chemotherapy-induced PTEN-L secretion promotes the selection of PTEN-deficient tumor cells

   Background

   PTEN loss has been identified in various tumor types and is linked to unfavorable clinical outcomes. In addition to PTEN mutation, multiple...

   Ming Wang, Zhenzhen Pan, ... Zhihai Qin in Journal of Experimental & Clinical Cancer Research

   Article Open access 11 May 2024
   

2. PTEN in Immunity

   The tumor suppressor PTEN (Phosphatase and Tensin homolog deleted on Chromosome 10) executes critical biological functions that limit cellular growth...

   Antonella Papa, Pier Paolo Pandolfi in PI3K and AKT Isoforms in Immunity

   Chapter 2022
   

3. Hyperphosphorylated PTEN exerts oncogenic properties

   PTEN is a multifaceted tumor suppressor that is highly sensitive to alterations in expression or function. The PTEN C-tail domain, which is rich in...

   Janine H. van Ree, Karthik B. Jeganathan, ... Jan M. van Deursen in Nature Communications

   Article Open access 24 May 2023
   

4. PTEN: an emerging target in rheumatoid arthritis?

   Phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) is a critical tumor suppressor protein that regulates various biological processes...

   Pan Zhou, **ngwen Meng, ... Yu Lei in Cell Communication and Signaling

   Article Open access 26 April 2024
   

5. Spatiotemporal distribution of PTEN before directed cell migration in monolayers

   The intracellular distribution of phosphatase and tensin homolog (PTEN) is closely related to directed cell migration. In single cells, PTEN...

   Quanzhi Lu, Saori Sasaki, ... Susumu Kudo in In Vitro Cellular & Developmental Biology - Animal

   Article 26 June 2024
   

6. Functional analysis of PTEN variants of unknown significance from PHTS patients unveils complex patterns of PTEN biological activity in disease

   Heterozygous germline mutations in PTEN gene predispose to hamartomas and tumors in different tissues, as well as to neurodevelopmental disorders,...

   Leire Torices, Janire Mingo, ... Rafael Pulido in European Journal of Human Genetics

   Article 21 December 2022
   

7. FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression

   FBXO32, a member of the F-box protein family, is known to play both oncogenic and tumor-suppressive roles in different cancers. However, the...

   Jie Wu, Ting Wen, ... Sida Qin in Cell Death & Disease

   Article Open access 20 April 2024
   

8. Correlation of PTEN signaling pathway and miRNA in breast cancer

   Breast cancer (BC) is one of the most common cancers among women and can be fatal if not diagnosed and treated on time. Various genetic and...

   Mahya Mohammadi, Ahmad Fazilat, ... Mohammad Valilo in Molecular Biology Reports

   Article 28 January 2024
   

9. Silencing of YTHDF1 Attenuates Cerebral Stroke by Inducing PTEN Degradation and Activating the PTEN/AKT/mTOR Pathway

   N6-methyladenosine (m6A) methylation regulates pathological processes of cerebral stroke, which can lead to disability and death. Herein, we explored...

   **aohong Li, Peng An, ... Ying Li in Molecular Biotechnology

   Article 19 October 2022
   

10. PTEN-restoration abrogates brain colonisation and perivascular niche invasion by melanoma cells

    Background

    Melanoma brain metastases (MBM) continue to be a significant clinical problem with limited treatment options. Highly invasive melanoma...

    Sarah Wang, Caroline P. Riedstra, ... Andrew C. Dudley in British Journal of Cancer

    Article 26 December 2023
    

11. PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1

    Background

    Although hepatitis B virus (HBV) infection is a major risk factor for hepatic cancer, the majority of HBV carriers do not develop this...

    Fuqiang Huang, **g Guo, ... Hongbing Zhang in Journal of Translational Medicine

    Article Open access 08 March 2024
    

12. Investigating the effects of PTEN mutations on cGAS-STING pathway in glioblastoma tumours

    Background

    PTEN is a tumour suppressor gene and well-known for being frequently mutated in several cancer types. Loss of immunogenicity can also be...

    Eda Dogan, Zafer Yildirim, ... Vildan Bozok in Journal of Neuro-Oncology

    Article Open access 12 January 2024
    

13. Reciprocal negative feedback regulation of ATF6α and PTEN promotes prostate cancer progression

    Phosphatase and tensin homolog (PTEN) loss tightly correlates with prostate cancer (PCa) progression and metastasis. Inactivation of PTEN leads to...

    Tingting Feng, Ru Zhao, ... Bo Han in Cellular and Molecular Life Sciences

    Article 16 September 2023
    

14. MicroRNA-542-3p targets Pten to inhibit the myoblasts proliferation but suppresses myogenic differentiation independent of targeted Pten

    Background

    Non-coding RNA is a key epigenetic regulation factor during skeletal muscle development and postnatal growth, and miR-542-3p was reported...

    Dandan Li, Yongqi Yue, ... Yan **ong in BMC Genomics

    Article Open access 01 April 2024
    

15. PTEN-regulated PI3K-p110 and AKT isoform plasticity controls metastatic prostate cancer progression

    PTEN loss, one of the most frequent mutations in prostate cancer (PC), is presumed to drive disease progression through AKT activation. However, two...

    Karina A. Miller, Seamus Degan, ... Irwin H. Gelman in Oncogene

    Article Open access 24 October 2023
    

16. PI3Kβ controls immune evasion in PTEN-deficient breast tumours

    Loss of the PTEN tumour suppressor is one of the most common oncogenic drivers across all cancer types ¹ . PTEN is the major negative regulator of PI3K...

    Johann S. Bergholz, Qiwei Wang, ... Jean J. Zhao in Nature

    Article 19 April 2023
    

17. PTEN decreases NR2F1 expression to inhibit ciliogenesis during EGFR^L858R-induced lung cancer progression

    Lung cancer is the major cause of death worldwide. Activation of oncogenes or inhibition of tumor suppressors causes cancer formation. Previous...

    Thi Thanh Truc Tran, Jan-Jong Hung in Cell Death & Disease

    Article Open access 18 March 2024
    

18. Inhibiting HSD17B8 suppresses the cell proliferation caused by PTEN failure

    Loss of the tumor suppressor PTEN homolog daf-18 in Caenorhabditis elegans (C. elegans ) triggers diapause cell division during L1 arrest. While prior...

    Wei Zhao, Ruiting Huang, ... Shanqing Zheng in Scientific Reports

    Article Open access 29 May 2024
    

19. The interplay of PTEN and AKT nexus in breast cancer: a molecular perspective

    Background

    Breast cancer is a highly prevalent and life-threatening ailment that is commonly detected among the females. The downregulation of PTEN ...

    Anum Kamal, Ali Raza Awan, ... Muhammad Wasim in Molecular Biology Reports

    Article 24 February 2024
    

20. Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients

    Background

    Tregs trafficking is controlled by CXCR4. In Renal Cell Carcinoma (RCC), the effect of the new CXCR4 antagonist, R54, was explored in...

    Sara Santagata, Giuseppina Rea, ... Stefania Scala in British Journal of Cancer

    Article Open access 04 May 2024