Search
Search Results
-
The Nuclear Localization Signal of NF-κB p50 Enters the Cells via Syndecan-Mediated Endocytosis and Inhibits NF-κB Activity
It is well established that cationic peptides can enter cells following attachment to polyanionic membrane components. We report that the basic...
-
Interaction of NF-κB and FOSL1 drives glioma stemness
Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor; GBM’s inevitable recurrence suggests that glioblastoma stem cells...
-
NF-κB in biology and targeted therapy: new insights and translational implications
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory...
-
Inhibition of DCUN1D1 attenuates periodontitis by suppressing NF-κB signaling
Nuclear factor kappa-B (NF-κB) signaling-mediated inflammation contributes greatly to the pathogenesis of periodontitis. Neddylation, a...
-
The impact of astrocytic NF-κB on healthy and Alzheimer’s disease brains
Astrocytes play a role in healthy cognitive function and Alzheimer’s disease (AD). The transcriptional factor nuclear factor-κB (NF-κB) drives...
-
NF-κB Transcription Factors Methods and Protocols
This detailed book serves as a systematic examination of the analytical methods to study the transcription factor NF-κB in physiology and disease. It...
-
Processing stimulus dynamics by the NF-κB network in single cells
Cells at the site of an infection experience numerous biochemical signals that vary in amplitude, space, and time. Despite the diversity of dynamic...
-
NF-κB signaling activation and roles in thyroid cancers: implication of MAP3K14/NIK
Among follicular-derived thyroid cancers (TC), those with aggressive behavior and resistance to current treatments display poor prognosis. NF-κB...
-
The role of NF-κB in carcinogenesis of cervical cancer: opportunities and challenges
The nuclear factor-κB (NF-κB) family, consisting of several transcription factors, has been implicated in the regulation of cell proliferation and...
-
NF-κB signaling in neoplastic transition from epithelial to mesenchymal phenotype
NF-κB transcription factors are critical regulators of innate and adaptive immunity and major mediators of inflammatory signaling. The NF-κB...
-
CLK2 mediates IκBα-independent early termination of NF-κB activation by inducing cytoplasmic redistribution and degradation
Activation of the NF-κB pathway is strictly regulated to prevent excessive inflammatory and immune responses. In a well-known negative feedback...
-
Inhibition of STAT3-NF-κB pathway facilitates SSPH I-induced ferroptosis in HepG2 cells
Hepatocellular carcinoma (HCC), a highly lethal solid tumor, has shown responsiveness to ferroptosis inducers, presenting new avenues in cancer...
-
Role of Transcription Factor NF-κB in Neuroimmunoendocrine Mechanisms of Respiratory Diseases
AbstractOne of the current challenges of biomedicine is to elucidate the multicomponent and multilevel mechanism of integrated...
-
Targeting NF-κB in Hepatic Ischemia–Reperfusion Alleviation: from Signaling Networks to Therapeutic Targeting
Hepatic ischemia–reperfusion injury (HIRI) is a major complication of liver trauma, resection, and transplantation that can lead to liver dysfunction...
-
The role of SARS-CoV-2-mediated NF-κB activation in COVID-19 patients
The SARS-CoV-2 pandemic, now in its third year, has had a profound impact on public health and economics all over the world. Different populations...
-
Aberrant non-canonical NF-κB signalling reprograms the epigenome landscape to drive oncogenic transcriptomes in multiple myeloma
In multiple myeloma, abnormal plasma cells establish oncogenic niches within the bone marrow by engaging the NF-κB pathway to nurture their survival...
-
NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression
Gliomas are highly invasive and chemoresistant cancers, making them challenging to treat. Chronic inflammation is a key driver of glioma progression...
-
NF-κB subunits direct kinetically distinct transcriptional cascades in antigen receptor-activated B cells
The nuclear factor kappa B (NF-κB) family of transcription factors orchestrates signal-induced gene expression in diverse cell types. Cellular...
-
Natural Extracts Target NF-κB and Reactive Oxygen Species
Two critical components integral to carcinogenesis are nuclear factor-kappa B (NF-κB) and reactive oxygen species (ROS). NF-κB performs various...
-
Acacetin Attenuates Sepsis-induced Acute Lung Injury via NLRC3-NF-κB Pathway
Acacetin, a flavonoid derived compound has been recognized for its diverse biological activities, such as anti-oxidative and anti-inflammatory...
