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Biophysical model for DNA mutations induced by retroviral genome insertion based on the probability density function of mutation distribution
Research into the biophysical properties of deoxyribonucleic acid (DNA) and the mechanisms underlying genetic mutations has undergone marked...
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A Mutation in Mediator Subunit MED16A Suppresses Nodulation and Increases Arbuscule Density in Medicago truncatula
Nodulation in legumes is regulated to maintain carbon–nitrogen homeostasis. A systemic negative feedback pathway, Autoregulation of Nodulation (AON)...
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An LRP6 mutation (Arg360His) associated with low bone mineral density but not cardiovascular events in a Caucasian family
SummaryWe present a family with a rare mutation of the LRP6 gene and for the first time provide evidence for its association with low bone mineral...
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Mutation Work on Other Ornamental Plants
The chapter covers mutation work (mutagens, working dose, mutants) carried out throughout the world on approximately 120 ornamental crops.
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A novel RBBP8(p.E281*) germline mutation is a predisposing mutation in familial hereditary cancer syndrome
AbstractScreening tumor susceptibility genes helps in identifying powerful biomarkers for hereditary cancer monitoring, prevention, and diagnosis,...
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Development of Rural Landraces Through Mutation Breeding Approaches
Modern agricultural operations employ crop improvement methods that have paradoxically diminished the genetic diversity of crop plants. Traditional...
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Artificial Hummingbird Algorithm Based on Tent Map** and Levy Mutation
Aiming at the shortcomings of Artificial Hummingbird Algorithm (AHA) such as slower convergence process, poor solution accuracy and early convergence...
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Adjusting Exploitation and Exploration Rates of Differential Evolution: A Novel Mutation Strategy
Differential evolution (DE) has attracted significant attention in recent years owing to its high performance in solving continuous problems. Up to...
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Strength of selection in lung tumors correlates with clinical features better than tumor mutation burden
Single nucleotide substitutions are the most common type of somatic mutations in cancer genome. The goal of this study was to use publicly available...
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Next Generation Mutation Detection Techniques in Crops
Forward and reverse genetic approaches are powerful ways to understand the genetics of traits of importance and to accelerate crop improvement...
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Selection-Mutation Models
In this chapter,we discuss the class of selection-mutation models. This class of models describe populations that are structured by, in addition to...
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Mutation Breeding Research in Sweet Pepper
Sweet pepper is delicious, loved, and an increasingly popular nutritional vegetable that is grown and produced in significant amounts throughout the...
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Generation of iPSC lines (KAIMRCi003A, KAIMRCi003B) from a Saudi patient with Dravet syndrome carrying homozygous mutation in the CPLX1 gene and heterozygous mutation in SCN9A
The most prevalent form of epileptic encephalopathy is Dravet syndrome (DRVT), which is triggered by the pathogenic variant SCN1A in 80% of cases....
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Embedded Mutation Strategies in Particle Swarm Optimization to Solve Camera Calibration Problem
Particle swarm optimization is a very effective nature-inspired algorithm which has been widely used in solving many real-world problems over the...
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Novel Gain-of-Function Mutation in the Kv11.1 Channel Found in the Patient with Brugada Syndrome and Mild QTc Shortening
AbstractBrugada syndrome (BrS) is an inherited disease characterized by right precordial ST-segment elevation in the right precordial leads on...
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Tumor cell density dependent IL-8 secretion induces the fluctuation of tregs/CD8 + T cells infiltration in hepatocellular carcinoma: one prompt for the existence of density checkpoint
BackgroundTumor cell density is a basic pathological feature of solid tumors. Chemotherapy, radiotherapy, and targeted therapy reduce tumor cell...
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Evaluation of Volumetric Bone Mineral Density, Bone Microarchitecture, and Bone Strength in Patients with Achondroplasia Caused by FGFR3 c.1138G > A Mutation
Achondroplasia (ACH) is a skeletal disorder caused by fibroblast growth factor receptor 3 ( FGFR3 ) variants. Volumetric bone mineral density (vBMD),...
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RNA Folding, Mutation, and Detection
The structure of RNA molecules is absolutely critical to their functions in a biological system. RNA structure is dynamic and changes in response to...
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Inconsistent Monthly Runoff Prediction Models Using Mutation Tests and Machine Learning
In a changing environment, the increasing inconsistency of runoff series complicates the development of runoff forecasting models. Mutation tests...
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Rapid Cycling and Generation Advancement for Accelerated Mutation Breeding in Sorghum
Rapid cycling techniques have become preferred methods in recent years to speed up the plant breeding process, especially for plant varieties...