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Ocular mucosal homeostasis of teleost fish provides insight into the coevolution between microbiome and mucosal immunity
BackgroundThe visual organ plays a crucial role in sensing environmental information. However, its mucosal surfaces are constantly exposed to...
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Nanotechnology of inhalable vaccines for enhancing mucosal immunity
Vaccines are the cornerstone of world health. The majority of vaccines are formulated as injectable products, facing the drawbacks of cold chain...
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Fish oral vaccine and mucosal immunity
Fish can be vaccinated by injection, intramuscularly (IM) or intraperitoneally (IP), and orally. Using oral immunization provides the most attractive...
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Mucosal Immunity in Fish
Mucosal barriers are dynamic structures that allow fish to interact with the external environment while maintaining homeostasis. Mucosal barriers are...
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The P2X7 receptor in mucosal adaptive immunity
The P2X7 receptor (P2X7R) is a widely distributed cation channel activated by extracellular ATP (eATP) with exclusive peculiarities with respect to...
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Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity
Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and...
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Polyanhydride nanovaccine against H3N2 influenza A virus generates mucosal resident and systemic immunity promoting protection
Influenza A virus (IAV) causes significant morbidity and mortality worldwide due to seasonal epidemics and periodic pandemics. The antigenic...
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Role of mucosal immunity and epithelial–vascular barrier in modulating gut homeostasis
The intestinal mucosa represents the most extensive human barrier having a defense function against microbial and food antigens. This barrier is...
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Ginseng-DF ameliorates intestinal mucosal barrier injury and enhances immunity in immunosuppressed mice by regulating MAPK/NF-κB signaling pathways
PurposeDietary fiber (DF) has a good application prospect in effectively restoring the integrity of the intestinal mucosal barrier. Ginseng-DF has...
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Multicomponent intranasal adjuvant for mucosal and durable systemic SARS-CoV-2 immunity in young and aged mice
Multiple FDA-approved SARS-CoV-2 vaccines currently provide excellent protection against severe disease. Despite this, immunity can wane relatively...
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A novel film spray containing curcumin inhibits SARS-CoV-2 and influenza virus infection and enhances mucosal immunity
BackgroundInfection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and influenza virus is still a major worldwide health concern....
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Mucosal immunity in health care workers’ respiratory tracts in the post-COVID-19 period
Coronavirus disease (COVID-19) has generated interest in the assessment of systemic immune status, but existing knowledge about mucosal immunity is...
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An intranasal combination vaccine induces systemic and mucosal immunity against COVID-19 and influenza
Despite prolonged surveillance and interventions, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses continue to...
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Mucosal Immunity After Novel COVID-19 Infection – Virus-Induced Immunosuppression: Preliminary Study
In recovered COVID-19 patients, the state of mucosal immunity remains understudied. Cytological, functional, and metabolic characteristics of...
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Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants
The highly contagious SARS-CoV-2 Omicron subvariants severely attenuated the effectiveness of currently licensed SARS-CoV-2 vaccines based on...
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Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization
Several effective SARS-CoV-2 vaccines are currently in use, but effective boosters are needed to maintain or increase immunity due to waning...
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Bacteroides-derived isovaleric acid enhances mucosal immunity by facilitating intestinal IgA response in broilers
BackgroundThe interaction between nutrition and immunity plays a vital role in nutrient digestion, absorption, and metabolism during poultry...
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Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice
Current vaccines against SARS-CoV-2 substantially reduce mortality, but protection against infection is less effective. Enhancing immunity in the...
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A single-dose of intranasal vaccination with a live-attenuated SARS-CoV-2 vaccine candidate promotes protective mucosal and systemic immunity
An attenuated SARS-CoV-2 virus with modified viral transcriptional regulatory sequences and deletion of open-reading frames 3, 6, 7 and 8 (∆3678) was...
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Mucosal Exposome and Intestinal Carcinogenesis
Mucosal exposomes are the internal frontline of defense against xenobiotics, pathogens, and microbiota. The mucosal network of human immunity is...