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1. Unravelling the effect of droplet size on lipid oxidation in O/W emulsions by using microfluidics

   Lipid oxidation in emulsions is hypothesised to increase with decreasing droplet size, as this increases the specific oil–water interfacial area,...

   Sten ten Klooster, Vincent J. P. Boerkamp, ... Claire C. Berton-Carabin in Scientific Reports

   Article Open access 17 April 2024
   

2. Lipid droplet biogenesis and functions in health and disease

   Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being recognized for their versatility beyond energy...

   Armella Zadoorian, **ming Du, Hongyuan Yang in Nature Reviews Endocrinology

   Article 23 May 2023
   

3. Combining albumin deficiency and acute exercise reduces hepatic lipid droplet size in mice

   Hepatic lipid droplets (LDs) are implicated in ectopic lipid accumulation. The core of LDs, triacylglycerol (TAG), is synthesized from the...

   Yi Zhang, Mirandia Szramowski, ... Gregory C. Henderson in Lipids in Health and Disease

   Article Open access 21 June 2023
   

4. PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in the retinal pigment epithelium

   Drusen, the yellow deposits under the retina, are composed of lipids and proteins, and represent a hallmark of age-related macular degeneration...

   Shuyan Zhou, Kaan Taskintuna, ... Nady Golestaneh in Cell Death & Disease

   Article Open access 01 June 2024
   

5. MT1G induces lipid droplet accumulation through modulation of H3K14 trimethylation accelerating clear cell renal cell carcinoma progression

   Background

   Lipid droplet formation is a prominent histological feature in clear cell renal cell carcinoma (ccRCC), but the significance and mechanisms...

   Sen Wang, Kexin Wang, ... Zhang Bin in British Journal of Cancer

   Article Open access 21 June 2024
   

6. Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet–mitochondria tethering to enhance β-oxidation and tumor cell proliferation

   Lipid droplet tethering with mitochondria for fatty acid oxidation is critical for tumor cells to counteract energy stress. However, the underlying...

   Ying Meng, Dong Guo, ... Zhimin Lu in Nature Metabolism

   Article 21 May 2024
   

7. Salinity stress-mediated lipid droplet production and liquid–liquid phase separation in Chlamydomonas reinhardtii

   High salt concentrations cause osmotic shock and oxidative imbalance in microalgal cells, thereby causing cell death. Innovative strategies are...

   Shubhangi Pandey, Priyal Visavadiya, ... Debjani Bagchi in The European Physical Journal Special Topics

   Article 31 May 2024
   

8. Droplet size and hydraulic spray nozzles in peanut plant spray deposition

   The quantity and quality of spray deposition are fundamental for improving pesticide performance in plant pests. This study evaluated how spray...

   Gabriela G. P. Buosi, Arthur D. R. Neto, ... Evandro P. Prado in Journal of Plant Diseases and Protection

   Article 01 September 2023
   

9. Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease

   Chronic kidney disease (CKD) is a global health problem with rising incidence and prevalence. Among several pathogenetic mechanisms responsible for...

   Alla Mitrofanova, Sandra Merscher, Alessia Fornoni in Nature Reviews Nephrology

   Article 27 July 2023
   

10. Effect of an acute long-duration exercise bout on skeletal muscle lipid droplet morphology, GLUT 4 protein, and perilipin protein expression

    Purpose

    Smaller lipid droplet morphology and GLUT 4 protein expression have been associated with greater muscle oxidative capacity and glucose uptake,...

    Sudip Bajpeyi, Jehu N Apaflo, ... Eric Ravussin in European Journal of Applied Physiology

    Article 27 June 2023
    

11. Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice

    Alzheimer’s disease, the most common age-related neurodegenerative disease, is characterized by tau aggregation and associated with disrupted...

    Jiyeon Lee, Julie M. Dimitry, ... Erik S. Musiek in Nature Communications

    Article Open access 25 August 2023
    

12. Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism

    Lipid droplets (LDs) are cellular organelles critical for lipid homeostasis, with intramyocyte LD accumulation implicated in metabolic...

    Lei Han, Dayang Huang, ... Lei Yang in Nature Cell Biology

    Article Open access 01 June 2023
    

13. Fat storage-inducing transmembrane proteins: beyond mediating lipid droplet formation

    Fat storage-inducing transmembrane proteins (FITMs) were initially identified in 2007 as members of a conserved endoplasmic reticulum (ER) resident...

    Gai** Wang, Anqi Chen, ... Guoying Yu in Cellular & Molecular Biology Letters

    Article Open access 08 November 2022
    

14. Lipid-droplet associated mitochondria promote fatty-acid oxidation through a distinct bioenergetic pattern in male Wistar rats

    Mitochondria empower the liver to regulate lipid homeostasis by enabling fatty acid oxidation during starvation and lipogenesis during nutrient-rich...

    Noble Kumar Talari, Ushodaya Mattam, ... Naresh Babu V. Sepuri in Nature Communications

    Article Open access 11 February 2023
    

15. Qa-SNARE syntaxin 18 mediates lipid droplet fusion with SNAP23 and SEC22B

    Lipid droplets (LDs) are dynamic lipid storage organelles that can sense and respond to changes in systemic energy balance. The size and number of...

    Yuhui Fu, Binbin Ding, ... Qing Zhong in Cell Discovery

    Article Open access 21 November 2023
    

16. Fusion of Peroxisome and Lipid Droplet Membranes: Expansion of a π-Shaped Structure

    Abstract

    Classical theory of fusion considers the fusion of bilayer membranes as a unification of the material of the membranes themselves and the...

    R. J. Molotkovsky, P. I. Kuzmin in Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology

    Article 09 December 2022
    

17. Differential lipid analysis of oxaliplatin-sensitive and resistant HCT116 cells reveals different levels of drug-induced lipid droplet formation

    Lipid droplets (LDs) are intracellular storage vesicles composed of a neutral lipid core surrounded by a glycerophospholipid membrane. LD...

    Tyler S. Larson, Thomas J. DiProspero, ... Matthew R. Lockett in Analytical and Bioanalytical Chemistry

    Article 02 November 2023
    

18. Energy Barrier of a Monolayer Stalk Formation during Lipid Droplet Fusion

    Abstract

    Lipid droplets are organelles responsible for the accumulation and breakdown of neutral fats in the human body. Lipid droplets have a...

    R. J. Molotkovsky in Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology

    Article 01 March 2024
    

19. Reconfigurable droplet networks

    Droplet networks stabilized by lipid interfacial bilayers or colloidal particles have been extensively investigated in recent years and are of great...

    Shuyi Sun, Shuailong Li, ... Shaowei Shi in Nature Communications

    Article Open access 05 February 2024
    

20. Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis

    Oxidative stress-induced lipid accumulation is mediated by lipid droplets (LDs) homeostasis, which sequester vulnerable unsaturated triglycerides...

    Qilun Zhang, Xuting Shen, ... Haoshu Fang in Nature Communications

    Article Open access 13 April 2024