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Impact of Istradefylline on Levodopa Dose Escalation in Parkinson’s Disease: ISTRA ADJUST PD Study, a Multicenter, Open-Label, Randomized, Parallel-Group Controlled Study
IntroductionA higher levodopa dose is a risk factor for motor complications in Parkinson’s disease (PD). Istradefylline (IST) is used as adjunctive...
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Effect of Carbidopa Dose on Levodopa Pharmacokinetics With and Without Catechol-O-Methyltransferase Inhibition in Healthy Subjects
Background and ObjectivesThe treatment of Parkinson’s disease (PD) is still symptomatic since disease-modifying treatments for PD are not available....
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High-dose versus low-dose inhaled levodopa (CVT-301) in patients with Parkinson disease for the treatment of OFF episodes: a meta-analysis of randomized controlled trials
BackgroundLevodopa is the most commonly used first-line drug for Parkinson’s disease. However, during the period of medication, the generation of...
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An updated calculator for determining levodopa-equivalent dose
Calculation of levodopa-equivalent dose in Parkinson’s disease has become common in research, but is also a useful tool in clinical practice,...
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Model-based optimization of controlled release formulation of levodopa for Parkinson’s disease
Levodopa is currently the standard of care treatment for Parkinson’s disease, but chronic therapy has been linked to motor complications. Designing a...
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Levodopa may modulate specific speech impairment in Parkinson's disease: an fMRI study
Hypokinetic dysarthria (HD) is a difficult-to-treat symptom affecting quality of life in patients with Parkinson’s disease (PD). Levodopa may...
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Inhaled levodopa for threatening impending OFF episodes in managing Parkinson’s disease
Parkinson’s disease (PD) is a neurodegenerative disorder that leads to the degeneration of dopaminergic neurons resulting in a widespread pathology...
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Subcutaneous Levodopa: A New Engine for the Vintage Molecule
The management of Parkinson’s disease (PD) continues to evolve with advancements in non-oral levodopa-based therapies aiming to provide continuous...
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Evaluating the impact of adjunctive istradefylline on the cumulative dose of levodopa-containing medications in Parkinson’s disease: study protocol for the ISTRA ADJUST PD randomized, controlled study
BackgroundLevodopa remains the most effective symptomatic treatment for Parkinson’s disease (PD) more than 50 years after its clinical introduction....
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Apprends-moi l'art des petits pas: Levodopa, Carbidopa Intestinal Gel plus Entacapone
We are always looking for the big breakthrough, ideally a cure for our advanced Parkinson’s disease (aPD) patients. As long as this does not happen...
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Effect of levodopa on postural blood pressure changes in Parkinson disease: a randomized crossover study
PurposeWe investigated the effect of levodopa on postural blood pressure changes in individuals with Parkinson disease (PD) with (PD +OH ) and without...
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The effect of levodopa treatment on vascular endothelial function in Parkinson’s disease
ObjectiveThere has been increasing awareness that micro-vascular alteration or vascular inflammation has been associated with levodopa-induced...
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A video-atlas of levodopa-induced dyskinesia in Parkinson’s disease: terminology matters
Dyskinesia is a common complication of long-term levodopa therapy in patients with Parkinson’s disease (PD), which often worsens the quality of life....
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Mitigating gut microbial degradation of levodopa and enhancing brain dopamine: Implications in Parkinson’s disease
Parkinson’s disease is managed using levodopa; however, as Parkinson’s disease progresses, patients require increased doses of levodopa, which can...
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Unlocking the potential: T1-weighed MRI as a powerful predictor of levodopa response in Parkinson’s disease
BackgroundThe efficacy of levodopa, the most crucial metric for Parkinson’s disease diagnosis and treatment, is traditionally gauged through the...
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Kinect-based objective assessment of the acute levodopa challenge test in parkinsonism: a feasibility study
IntroductionThe acute levodopa challenge test (ALCT) is an important and valuable examination but there are still some shortcomings with it. We aimed...
