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Biphenotypic Cells and α-Synuclein Accumulation in Enteric Neurons of Leucine-Rich Repeat Kinase 2 Knockout Mice
BackgroundLeucine-rich repeat kinase 2 is a molecule that is responsible for familial Parkinson’s disease. Our previous findings revealed that...
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Structure and regulation of full-length human leucine-rich repeat kinase 1
The human leucine-rich repeat kinases (LRRKs), LRRK1 and LRRK2 are large and unusually complex multi-domain kinases, which regulate fundamental...
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Regional nigral neuromelanin degeneration in asymptomatic leucine-rich repeat kinase 2 gene carrier using MRI
Asymptomatic Leucine-Rich Repeat Kinase 2 Gene (LRRK2) carriers are at risk for develo** Parkinson's disease (PD). We studied presymptomatic...
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Multi-method computational evaluation of the inhibitors against leucine-rich repeat kinase 2 G2019S mutant for Parkinson's disease
Leucine-rich repeat kinase 2 G2019S mutant (LRRK2 G2019S) is a potential target for Parkinson's disease therapy. In this work, the computational...
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Leucine-rich repeat kinase 2 limits dopamine D1 receptor signaling in striatum and biases against heavy persistent alcohol drinking
The transition from hedonic alcohol drinking to problematic drinking is a hallmark of alcohol use disorder that occurs only in a subset of drinkers....
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Deficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice
BackgroundHepatic encephalopathy (HE) is closely associated with inflammatory responses. However, as a crucial regulator of the immune and...
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Leucine-Rich Repeat Receptor-Like Proteins in Plants: Structure, Function, and Signaling
Leucine-rich repeat receptor-like proteins (LRR-RLPs) and LRR receptor-like kinases (LRR-RLKs) are transmembrane receptors that act as critical...
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Crystal structures of FNIP/FGxxFN motif-containing leucine-rich repeat proteins
The Cafeteria roenbergensis virus (Crov), Dictyostelium , and other species encode a large family of leucine-rich repeat (LRR) proteins with FGxxFN...
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TuRLK1, a leucine-rich repeat receptor-like kinase, is indispensable for stripe rust resistance of YrU1 and confers broad resistance to multiple pathogens
BackgroundYrU1 is a nucleotide-binding site (NBS) and leucine-rich repeat (LRR) protein (NLR), with additional ankyrin-repeat and WRKY domains and...
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A maize leucine-rich repeat receptor-like protein kinase mediates responses to fungal attack
Main conclusionA maize receptor kinase controls defense response to fungal pathogens by regulating jasmonic acid and antimicrobial phytoalexin...
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Chloride Channel-3 (ClC-3) Modifies the Trafficking of Leucine-Rich Repeat-Containing 8A (LRRC8A) Anion Channels
Chloride channel-3 (ClC-3) Cl − /H + antiporters and leucine-rich repeat-containing 8 (LRRC8) family anion channels have both been associated with...
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Increased level of serum leucine-rich-alpha-2-glycoprotein 1 in patients with clear cell renal cell carcinoma
BackgroundCurrently, no useful serum markers exist for clear cell renal cell carcinoma (ccRCC), making early detection challenging as diagnosis...
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Loss of pleckstrin homology domain and leucine-rich repeat protein phosphatase 2 has protective effects on high glucose-injured retinal ganglion cells via the effect on the Akt–GSK–3β–Nrf2 pathway
ObjectivePleckstrin homology domain and leucine-rich repeat protein phosphatase 2 (PHLPP2) is linked to various pathological states. However, whether...
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Pseudomonas phaseolicola preferentially modulates genes encoding leucine-rich repeat and malectin domains in the bean landrace G2333
Main conclusionCandidate resistance genes encoding malectin-like and LRR domains mapped to halo blight resistance loci throughout the common bean...
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Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling
PurposeIschemic postconditioning (IPostC) alleviates myocardial ischemia/reperfusion (IR) injury, but the protective effect is lost during diabetes....
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BAK-up: the receptor kinase BAK-TO-LIFE 2 enhances immunity when BAK1 is lacking
BRI1-ASSOCIATED KINASE 1 (BAK1/SERK3) and its closest homolog BAK1-LIKE 1 (BKK1/SERK4) are leucine-rich repeat receptor kinases (LRR-RKs) belonging...
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The role of leucine-rich alpha-2-glycoprotein-1 in proliferation, migration, and invasion of tumors
BackgroundLeucine-rich alpha-2-glycoprotein-1 (LRG1) is widely involved in proliferation, migration, and invasion of various tumor cells. Recent...
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Genome-wide identification of nucleotide-binding domain leucine-rich repeat (NLR) genes and their association with green peach aphid (Myzus persicae) resistance in peach
Resistance genes (R genes) are a class of genes that are immune to a wide range of diseases and pests. In planta, NLR genes are essential components...
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Small Leucine-Rich Proteoglycans Regulate Cancer Cell Growth, Apoptosis, and Associated Inflammation
The tumor microenvironment, apart from tumor cells, contains tissue nonmalignant cells, blood vessels, stromal cells, infiltrating immune cells, and...
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Structural and functional implications of leucine-rich repeats in toll-like receptor1 subfamily
Leucine-rich repeats (LRRs) – the protein–protein and protein–ligand interaction motif of proteins participating in a plethora of functions in...
