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p53 positively regulates the proliferation of hepatic progenitor cells promoted by laminin-521
Hepatic progenitor cells (HPCs) hold tremendous potential for liver regeneration, but their well-known limitation of proliferation hampers their...
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Laminin 521 Modulates the Сytotoxic Effect of 5-Fluorouracil on HT29 Colorectal Cancer Cells
AbstractThe cytotoxic effect of 5-fluorouracil (5FU) and regorafenib (RF), drugs with different mechanisms of action used to treat colorectal cancer,...
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A Novel Fluorescent Reporter System Identifies Laminin-511/521 as Potent Regulators of Cardiomyocyte Maturation
Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) hold great promise for disease modeling and drug discovery. However, PSC-CMs exhibit immature...
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Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures
Human pluripotent stem cell (hPSC)-derived neurons provide exciting opportunities for in vitro modeling of neurological diseases and for advancing...
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Pluripotent stem cell-derived committed cardiac progenitors remuscularize damaged ischemic hearts and improve their function in pigs
Ischemic heart disease, which is often associated with irreversibly damaged heart muscle, is a major global health burden. Here, we report the...
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Establishing extended pluripotent stem cells from human urine cells
BackgroundExtended pluripotent stem cells (EPSCs) can contribute to both embryonic and trophectoderm-derived extraembryonic tissues. Therefore, EPSCs...
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Laminin fragments conjugated with perlecan’s growth factor-binding domain differentiate human induced pluripotent stem cells into skin-derived precursor cells
Deriving stem cells to regenerate full-thickness human skin is important for treating skin disorders without invasive surgical procedures. Our...
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The extracellular matrix complexity of idiopathic epiretinal membranes and the bilaminar arrangement of the associated internal limiting membrane in the posterior retina
PurposeTo study the composition of the internal limiting membrane (ILM) of the retina, the extracellular matrix (ECM) of idiopathic epiretinal...
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Truncated vitronectin with E-cadherin enables the xeno-free derivation of human embryonic stem cells
Human embryonic stem cells (hESCs) have unique abilities that enable their use in cell therapy, disease modeling, and drug development. Their...
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Chain-specificity of laminin α1-5 LG45 modules in the recognition of carbohydrate-linked receptors and intramolecular binding
Laminins are a family of heterotrimers composed of α-, β-, and γ-chains in the basement membrane. Five α chains contain laminin globular (LG) domain...
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Restoration of Podocyte Phenotype in Culture
The most distinctive characteristic of podocytes in the kidney is the presence of interdigitating cell processes with nephrin and podocin that are...
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Exogenous laminin exhibits a unique vascular pattern in the brain via binding to dystroglycan and integrins
BackgroundUnlike other proteins that exhibit a diffusion pattern after intracerebral injection, laminin displays a vascular pattern. It remains...
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Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells
In vitro differentiation of human pluripotent stem cells into functional retinal pigment epithelial (RPE) cells provides a potentially unlimited...
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Generation of proximal tubule-enhanced kidney organoids from human pluripotent stem cells
Kidney organoids derived from human pluripotent stem cells (hPSCs) are now being used as models of renal disease and nephrotoxicity screening....
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Serum-Free Production of Human Stem Cell-Derived Liver Spheres for Cancer Metastasis Research
Renewable and scalable human liver tissue platforms are a powerful tool to study organ physiology and model diseases, such as cancer. Stem...
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Generating Human Glomeruli from Pluripotent Stem Cells for Disease Modelling and Drug Screening
The functional unit of human kidney is the nephronNephrons. This structure is composed of a glomerulus, connected to a tubule that drains into a...
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Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance
BackgroundLaminin-α5, a major component of the basal lamina, is predominantly synthesized by endothelial and mural cells (pericytes and vascular...
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Mesenchymal stromal cell-associated migrasomes: a new source of chemoattractant for cells of hematopoietic origin
BackgroundMultipotent mesenchymal stromal cells (MSCs) are precursors of various cell types. Through soluble factors, direct cell–cell interactions...
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Mouse embryonic stem cell-derived blood–brain barrier model: applicability to studying antibody triggered receptor mediated transcytosis
Blood brain barrier (BBB) models in vitro are an important tool to aid in the pre-clinical evaluation and selection of BBB-crossing therapeutics....
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Induced Pluripotent Stem Cells in Epithelial Lamellar Keratoplasty
Limbal stem cell (LSC) transplantation is required to restore vision in patients suffering from limbal stem cell deficiency (LSCD). Unfortunately,...