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Benign Soft-Tissue Tumors
Soft-tissue tumors are a group of neoplasms of mesenchymal origin. They can be classified depending on their cellular differentiation and/or the...
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Soft Tissue Sarcomas
Soft tissue sarcomas are a rare disease. However, while overall they account for less than 1% of all malignant tumors, in childhood and adolescence,...
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What is the optimal (neo)adjuvant strategy of extremity high-risk soft tissue sarcomas (ESTS)?
Currently, the standard treatment for extremity high-risk soft tissue sarcomas (ESTS) combines surgery and pre- or post-op radiation therapy (RT). In...
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High cumulative doxorubicin dose for advanced soft tissue sarcoma
BackgroundThe recommended cumulative doxorubicin dose in soft tissue sarcoma (STS) treatment was based on cardiotoxicity data from retrospective...
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Health-related quality of life in patients with extremity bone sarcoma after surgical treatment: a systematic review
PurposeWe conducted a systematic review of studies reporting on measurement of health-related quality of life (HRQoL), with a special focus on the...
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Imaging in rhabdomyosarcoma: a patient journey
Rhabdomyosarcoma, although rare, is the most frequent soft tissue sarcoma in children and adolescents. It can present as a mass at nearly any site in...
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Hereditary Factors in Carcinogenesis and the Key Cancer Syndromes
Cancer is a genetic disease—with the role of somatic mutations in tumor cells well-described in all cancer types. The role of germline genetic...
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Activation of recombinational repair in Ewing sarcoma cells carrying EWS-FLI1 fusion gene by chromosome translocation
Chromosome translocation (TL) is an important mode of genomic changes underlying human tumorigenesis, the detailed mechanisms of which are, however,...
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Middle-out methods for spatiotemporal tissue engineering of organoids
Organoids recapitulate many aspects of the complex three-dimensional (3D) organization found within native tissues and even display tissue and...
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‘I thought I had fibroids, and now I don’t’: a mixed method study on health-related quality of life in uterine sarcoma patients
BackgroundUterine sarcomas are rare subtypes of primary urogenital tumours and need tailored treatment. This study aimed to examine the impact of...
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Malignant spinal cord compression in the paediatric population—a systematic review, meta-analysis
BackgroundMalignant spinal cord compression (MSCC) has been noted in 3–5% of children with primary tumours. MSCC can be associated with permanent...
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Impact of human adipose tissue-derived stem cells on dermatofibrosarcoma protuberans cells in an indirect co-culture: an in vitro study
BackgroundAutologous adipose tissue transfer may be performed for aesthetic needs following the resection of dermatofibrosarcoma protuberans (DFSP),...
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Molecular phenoty** using networks, diffusion, and topology: soft tissue sarcoma
Many biological datasets are high-dimensional yet manifest an underlying order. In this paper, we describe an unsupervised data analysis methodology...
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Adamantinoma-Like Ewing Sarcoma of the Head and Neck: A Case-Series of a Rare and Challenging Diagnosis
Adamantinoma-like Ewing sarcoma (ALES) is a rare malignant tumor characterized by EWSR1::FLI1 related fusions and complex epithelial differentiation....
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In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling
EWS RNA binding protein 1 (EWSR1) is a multifunctional protein whose epigenetic signatures contribute to the pathogenesis of various human diseases,...
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Development of a patient-reported experience questionnaire for patients with sarcoma: the Sarcoma Assessment Measure (SAM)
PurposeThe aim of the study was to develop a patient-reported outcome measure for patients with sarcoma—the Sarcoma Assessment Measure (SAM).
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Negative pressure wound therapy promotes wound healing of diabetic foot ulcers by up-regulating PRDX2 in wound margin tissue
To understand the changes in the peroxiredoxin-2 (PRDX2) expression level in the wound margin tissue (T-PRDX2) of patients with diabetic foot ulcer...
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Understanding a mass in the paraspinal region: an anatomical approach
The paraspinal region encompasses all tissues around the spine. The regional anatomy is complex and includes the paraspinal muscles, spinal nerves,...
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Key Immune Checkpoint PD-1/PD-L1 Signaling Pathway Components in the Blood Serum from Patients with Bone Tumors
The levels of sPD-1 and sPD-L1 were analyzed in blood serum of 132 patients (age 14-70 years) with primary bone tumors: osteosarcoma ( N =39),...