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Multifunctional redox modulator prevents blast-induced loss of cochlear and vestibular hair cells and auditory spiral ganglion neurons
Blast wave exposure, a leading cause of hearing loss and balance dysfunction among military personnel, arises primarily from direct mechanical damage...
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MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation
BackgroundSensorineural hearing loss (SNHL) poses a major threat to both physical and mental health; however, there is still a lack of effective...
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Deletion of the Notch ligand Jagged1 during cochlear maturation leads to inner hair cell defects and hearing loss
The mammalian cochlea is an exceptionally well-organized epithelium composed of hair cells, supporting cells, and innervating neurons. Loss or...
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Role of Endogenous Ca \(^{2+}\) Buffering and the Readily Releasable Pool on Fast Secretion in Auditory Inner Hair Cells
Sensory hair cells, located at the cochlea, convert sound into a depolarizing stimulus that, as a response to an increase in the intracellular Ca...
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The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell
The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on...
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TBX2 specifies and maintains inner hair and supporting cell fate in the Organ of Corti
The auditory function of the mammalian cochlea relies on two types of mechanosensory hair cells and various non-sensory supporting cells. Recent...
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Nuclear Translocation Triggered at the Onset of Hearing in Cochlear Inner Hair Cells of Rats and Mice
PurposeNuclear position is precisely orchestrated during cell division, migration, and maturation of cells and tissues. Here we report a previously...
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Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear
Hearing loss has become increasingly prevalent and causes considerable disability, thus gravely burdening the global economy. Irreversible loss of...
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Fgf8P2A-3×GFP/+: A New Genetic Mouse Model for Specifically Labeling and Sorting Cochlear Inner Hair Cells
The cochlear auditory epithelium contains two types of sound receptors, inner hair cells (IHCs) and outer hair cells (OHCs). Mouse models for...
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A Low Dose of Rapamycin Promotes Hair Cell Differentiation by Enriching SOX2+ Progenitors in the Neonatal Mouse Inner Ear Organoids
PurposeTo investigate the impact of rapamycin on the differentiation of hair cells.
MethodsMurine cochlear organoids were derived from cochlear...
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Inner Ear Cells from Stem Cells: A Path Towards Inner Ear Cell Regeneration
Investigating the mammalian inner ear’s sensory epithelia has been limited by the lack of accessibility, being embedded in dense bone, and further...
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AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo
BackgroundUncoupling protein 2 (UCP2), activated by excessive reactive oxygen species (ROS) in vivo, has the dual effect of reducing ROS to protect...
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The proper timing of Atoh1 expression is pivotal for hair cell subtype differentiation and the establishment of inner ear function
Atoh1 overexpression is essential for hair cell (HC) regeneration in the sensory epithelium of mammalian auditory and vestibular organs. However, Atoh1 ...
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Identifying bifurcations underlying a neuronal bursting of mixed-mode oscillations with two slow variables in inner hair cell
Neuronal bursting patterns are nonlinear behaviors related to various brain functions and diseases. Bursting modulated by two slow variables manifest...
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Integrated scRNAseq analyses of mouse cochlear supporting cells reveal the involvement of Ezh2 in hair cell regeneration
BackgroundIn lower vertebrates like fish, the inner ear and lateral line hair cells (HCs) can regenerate after being damaged by...
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Mammalian Hair Cell Regeneration
In adult mammals, there is no hair cell regeneration in the cochlea and a limited capacity in the vestibular organs. Research in this area is...
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The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration
Neurons and sensory cells are particularly vulnerable to oxidative stress due to their high oxygen demand during stimulus perception and...
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Age-related changes in the zebrafish and killifish inner ear and lateral line
Age-related hearing loss (ARHL) is a debilitating disorder for millions worldwide. While there are multiple underlying causes of ARHL, one common...
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No Reduction in the 226-Hz Probe Tone Acoustic Reflex Amplitude Following Severe Inner Hair Cell Loss in Chinchillas
The relationship between the middle ear acoustic reflex (AR) and inner hair cell (IHC) loss is currently unknown. Given that IHC are believed to...
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The History of Auditory Research in Lizards
Although many early anatomical papers touched on lizard ears, the absence of accurate tools severely limited progress. After 1950, new techniques...