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Establishment of primary prostate epithelial and tumorigenic cell lines using a non-viral immortalization approach
BackgroundResearch on prostate cancer is mostly performed using cell lines derived from metastatic disease, not reflecting stages of tumor initiation...
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The other side of the coin: mesenchymal stromal cell immortalization beyond evasion of senescence
Mesenchymal stromal cells (MSC) are promising options to cellular therapy to several clinical disorders, mainly because of its ability to...
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Hypoxia-induced immortalization of primary cells depends on Tfcp2L1 expression
Cellular senescence is a stress response mechanism that induces proliferative arrest. Hypoxia can bypass senescence and extend the lifespan of...
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Spontaneous immortalization of chicken fibroblasts generates stable, high-yield cell lines for serum-free production of cultured meat
Cellular agriculture could meet growing demand for animal products, but yields are typically low and regulatory bodies restrict genetic modification...
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A non-genetic switch triggers alternative telomere lengthening and cellular immortalization in ATRX deficient cells
Alternative Lengthening of Telomeres (ALT) is an aberrant DNA recombination pathway which grants replicative immortality to approximately 10% of all...
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Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation
The lack of a scalable and robust source of well-differentiated human atrial myocytes constrains the development of in vitro models of atrial...
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Immortalization of primary cells derived from the endangered Ryukyu long-furred rat
The Ryukyu long-furred rat is an endangered species confined to the southernmost three small islands of Japan (Amami-Oshima, Tokunoshima, and...
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Novel immortalization approach defers senescence of cultured canine adipose-derived mesenchymal stromal cells
In the last decades, the scientific community spared no effort to elucidate the therapeutic potential of mesenchymal stromal cells (MSCs)....
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Immortalization effect of SV40T lentiviral vectors on canine corneal epithelial cells
BackgroundPrimary canine corneal epithelial cells (CCECs) easily become senescent, and cell proliferation is limited. Therefore, sampling for...
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Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity
Immortalization-upregulated protein (IMUP) plays a vital role in cell proliferation and tumor progression. However, its role in pancreatic ductal...
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Immortalization of primary sheep embryo kidney cells
Sheep primary epithelial cells are short-lived in cell culture systems. For long-term in vitro studies, primary cells need to be immortalized. This...
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Immortalization of Human Keratinocytes Using the Catalytic Subunit of Telomerase
AbstractA new stable line of human keratinocytes was obtained. The cells have altered morphology, both abnormal chromosomal composition and...
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Immortalization of human primary prostate epithelial cells via CRISPR inactivation of the CDKN2A locus and expression of telomerase
BackgroundImmortalization of primary prostate epithelial cells (PrEC) with just hTERT expression is particularly inefficient in the absence of DNA...
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Immortalization of cells derived from domestic dogs through expressing mutant cyclin-dependent kinase 4, cyclin D1, and telomerase reverse transcriptase
Dog is the first animal that was established as a close partner of human beings. Based on the vast genetic diversity and breeding, dogs exhibit...
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Establishing a papillary craniopharyngioma cell line by SV40LT-mediated immortalization
BackgroundCraniopharyngioma represents a troublesome tumor of the intracranial sellar region. There are currently no available well-characterized...
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Immortalization of Mesenchymal Stromal Cells by TERT Affects Adenosine Metabolism and Impairs their Immunosuppressive Capacity
Mesenchymal stromal cells (MSCs) are promising candidates for cell-based therapies, mainly due to their unique biological properties such as...
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Immortalized cell lines derived from dental/odontogenic tissue
Stem cells derived from dental/odontogenic tissue have the property of multiple differentiation and are prospective in tooth regenerative medicine...
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Characterization of immortalized ovarian epithelial cells with BRCA1/2 mutation
We aimed to elucidate the mechanism underlying carcinogenesis by comparing normal and BRCA1/2- mutated ovarian epithelial cells established via Sendai...
