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1. Application of a Novel Aptamer Beacon for Rapid Detection of IgG1 Antibody Drugs

   Antibody drugs have been widely used to treat many diseases and are the fastest-growing drug class. IgG1 is the most common type of antibody because...

   Ke Yang, Wei-Wei Zheng, ... Cai-Wen Duan in Applied Biochemistry and Biotechnology

   Article 28 March 2023
   

2. Immunohistological analysis reveals IgG1-dominant immunophenotype of tubulointerstitial nephritis unassociated with IgG4-related diseases

   Purpose

   Tubulointerstitial nephritis (TIN) has various etiologies, including IgG4-related disease (IgG4-RD), autoimmune diseases, antineutrophil...

   Toshiki Hyodo, Shigeo Hara, ... Tomoo Itoh in International Urology and Nephrology

   Article Open access 21 February 2024
   

3. Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern

   Existing assays to measure antibody cross-reactivity against different SARS-CoV-2 spike (S) protein variants lack the discriminatory power to provide...

   Danique M. H. van Rijswijck, Albert Bondt, ... Albert J. R. Heck in Nature Communications

   Article Open access 15 October 2022
   

4. B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergy

   Mutated and unmutated IgE and IgG play different and partly opposing roles in allergy development, but the mechanisms controlling their relative...

   Christopher C. Udoye, Christina N. Rau, ... Rudolf A. Manz in Mucosal Immunology

   Article Open access 16 September 2022
   

5. The hinge-engineered IgG1-IgG3 hybrid subclass IgGh₄₇ potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies

   Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have...

   Arman Izadi, Yasaman Karami, ... Pontus Nordenfelt in Nature Communications

   Article Open access 27 April 2024
   

6. Effect of Fc core fucosylation and light chain isotype on IgG1 flexibility

   N-glycosylation plays a key role in modulating the bioactivity of monoclonal antibodies (mAbs), as well as the light chain (LC) isotype can influence...

   Simona Saporiti, Tommaso Laurenzi, ... Ivano Eberini in Communications Biology

   Article Open access 03 March 2023
   

7. IgG1-Antikörper wirkt bei Psoriasis

   Redaktion Facharztmagazine in hautnah dermatologie

   Article 20 September 2023

8. Production of recombinant human IgG1 Fc with beneficial N-glycosylation pattern for anti-inflammatory activity using genome-edited chickens

   Intravenous immunoglobulin (IVIG) is a plasma-derived polyclonal IgG used for treatment of autoimmune diseases. Studies show that α-2,6 sialylation...

   ** Se Park, Hee Jung Choi, ... Jae Yong Han in Communications Biology

   Article Open access 01 June 2023
   

9. Comparative sedimentation equilibrium analysis of two IgG1 glycoforms: IgGCri and IgGWid

   The solution properties of two different glycoforms of IgG1 (IgG1Cri and IgG1Wid) are compared using primarily sedimentation equilibrium analysis...

   Khalil Abu Hammad, Vlad Dinu, ... Stephen E. Harding in European Biophysics Journal

   Article Open access 17 May 2023
   

10. Uniform [¹³C,¹⁵N]-labeled and glycosylated IgG1 Fc expressed in Saccharomyces cerevisiae

    Despite the prevalence and importance of glycoproteins in human biology, methods for isotope labeling suffer significant limitations. Common...

    Alexander R. Davis, Elijah T. Roberts, ... Adam W. Barb in Journal of Biomolecular NMR

    Article 21 November 2023
    

11. IgG1 and IgG4 antibodies sample initial structure dependent local conformational states and exhibit non-identical Fab dynamics

    Ramakrishnan Natesan, Neeraj J. Agrawal in Scientific Reports

    Article Open access 23 March 2023
    

12. Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture

    Abstract

    The pharmaceutical industry employs various strategies to improve cell productivity. These strategies include process intensification,...

    George Liang, Chikkathur N. Madhavarao, ... Seongkyu Yoon in Applied Microbiology and Biotechnology

    Article Open access 26 March 2024
    

13. Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life

    Antibody-based therapeutics (ABTs) are used to treat a range of diseases. Most ABTs are either full-length IgG1 antibodies or fusions between for...

    Torleif Tollefsrud Gjølberg, Rahel Frick, ... Jan Terje Andersen in Communications Biology

    Article Open access 18 August 2022
    

14. Assessment of safety and intranasal neutralizing antibodies of HPMC-based human anti-SARS-CoV-2 IgG1 nasal spray in healthy volunteers

    An HPMC-based nasal spray solution containing human IgG1 antibodies against SARS-CoV-2 (nasal antibody spray or NAS) was developed to strengthen...

    Thanarath Imsuwansri, Thitinan Jongthitinon, ... Trairak Pisitkun in Scientific Reports

    Article Open access 20 September 2023
    

15. Prognostic implication of IgG4 and IgG1-positive cell infiltration in the lung in patients with idiopathic interstitial pneumonia

    Immunoglobulin (Ig) G4-positive cells are rarely observed in the lungs of patients with idiopathic interstitial pneumonias (IIPs). IgG1 may be more...

    Masamichi Komatsu, Hiroshi Yamamoto, ... Masayuki Hanaoka in Scientific Reports

    Article Open access 03 June 2022
    

16. Mechanistic insights into inter-chain disulfide bond reduction of IgG1 and IgG4 antibodies

    Abstract

    Therapeutic monoclonal antibodies (mAbs), primarily immunoglobin G1 (IgG1) and IgG4 with an engineered CPPC motif in its hinge region, are...

    Yuanli Song, Hui Cai, ... Zheng-Jian Li in Applied Microbiology and Biotechnology

    Article 24 January 2022
    

17. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: an entity associated with distinct diseases and comparison between IgG1 and IgG3 subtypes

    Objectives

    The aim of the study was to investigate the clinicopathological characteristics and prognosis of proliferative glomerulonephritis with...

    Mengyao Liu, **aojuan Yu, ... Minghui Zhao in Journal of Nephrology

    Article 23 April 2022
    

18. IgG1-Antikörper verbessert Psoriasis schnell und anhaltend

    Martina Eimer in hautnah dermatologie

    Article 23 January 2023

19. A novel monospecific tetravalent IgG1-(scFv)₂ version shown enhanced neutralizing and Fc-mediated effector functions against SARS-CoV-2

    Neutralizing monoclonal antibodies (nMABs) have been proved to be effective therapeutics in treating coronavirus disease (COVID-19). To enhance the...

    Zhang-zhao Gao, **g-yu Jiao, ... Hai-bin Wang in 3 Biotech

    Article 25 July 2023
    

20. Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody

    The fragment-antigen-binding arms (Fab1 and Fab2) in a canonical immunoglobulin G (IgG) molecule have identical sequences and hence are always...

    Ramakrishnan Natesan, Neeraj J. Agrawal in Scientific Reports

    Article Open access 04 June 2022