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CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma
Adult T-cell leukemia/lymphoma (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1). In addition to HTLV-1 bZIP factor ( HBZ ), a...
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Viral, genetic, and immune factors in the oncogenesis of adult T-cell leukemia/lymphoma
Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature CD4 + T cells induced by human T-cell leukemia virus type I (HTLV-1). HTLV-1 maintains...
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Human T-cell lymphotropic virus type 1 (HTLV-1) proposed vaccines: a systematic review of preclinical and clinical studies
BackgroundNumerous vaccination research experiments have been conducted on non-primate hosts to prevent or control HTLV-1 infection. Therefore,...
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CRISPR Targeting the Integrated HTLV-1 Virus
Human T-cell leukemia virus type 1 (HTLV-1) is a complex deltaretrovirus. As the only oncogenic human retrovirus known to date, HTLV-1 is the...
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Proteoty** of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma
We proteotyped blood plasma from 30 mouse knockout strains and corresponding wild-type mice from the International Mouse Phenoty** Consortium. We...
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Adult T-Cell Leukemia: a Comprehensive Overview on Current and Promising Treatment Modalities
Purpose of the ReviewAdult T-cell leukemia (ATL) is an aggressive chemo-resistant malignancy secondary to HTLV-1 retrovirus. Prognosis of ATL remains...
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HTLV-1 Replication and Adult T Cell Leukemia Development
Human T-cell leukemia virus type 1 (HTLV-1) was discovered in 1980 as the first, and to date, the only retrovirus that causes human cancer. While...
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3,3′,5-Triiodothyroacetic acid (TRIAC) induces embryonic ζ-globin expression via thyroid hormone receptor α
The human ζ-globin gene ( HBZ ) is transcribed in primitive erythroid cells only during the embryonic stages of development. Reactivation of this...
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The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression
Eukaryotic initiation translation factor 3 subunit h (EIF3H) plays critical roles in regulating translational initiation and predicts poor cancer...
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Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections
Killer-cell immunoglobulin-like receptors (KIRs) are mainly expressed on natural killer (NK) cells and are key regulators of innate immune responses....
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Comprehensive Insight into the Functional Roles of NK and NKT Cells in HTLV-1-Associated Diseases and Asymptomatic Carriers
Human T cell leukemia virus type 1 (HTLV-1) is the first human oncogenic retrovirus to be discovered and causes two major diseases: a progressive...
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Reactivation of a developmentally silenced embryonic globin gene
The α- and β-globin loci harbor developmentally expressed genes, which are silenced throughout post-natal life. Reactivation of these genes may offer...
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Designer nucleases to treat malignant cancers driven by viral oncogenes
Viral oncogenic transformation of healthy cells into a malignant state is a well-established phenomenon but took decades from the discovery of...
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The role and regulation of Maf proteins in cancer
The Maf proteins (Mafs) belong to basic leucine zipper transcription factors and are members of the activator protein-1 (AP-1) superfamily. There are...
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Human T-lymphotropic virus type 1 (HTLV-1) and cellular immune response in HTLV-1-associated myelopathy/tropical spastic paraparesis
Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic...
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Systemic Onco-Spheres: Viruses in Cancer
It was recently estimated that a virus infection is the central cause of more than 1,400,000 cancer cases annually, representing approximated 10% of...
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Human T-cell leukaemia virus type 1 associated pulmonary disease: clinical and pathological features of an under-recognised complication of HTLV-1 infection
The lung is one of several organs that can be affected by HTLV-1 mediated inflammation. Pulmonary inflammation associated with HTLV-1 infection...
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Current Concepts and Advances in Oncobiology
Embarking on the dynamic landscape of oncology, this chapter navigates the interface between emerging concepts and transformative advancements in...
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Current Concepts and Advances in Oncobiology
Embarking on the dynamic landscape of oncology, this chapter navigates the interface between emerging concepts and transformative advancements in...
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Engineered small extracellular vesicles as a novel platform to suppress human oncovirus-associated cancers
BackgroundCancer, as a complex, heterogeneous disease, is currently affecting millions of people worldwide. Even if the most common traditional...
