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Granulocyte macrophage colony stimulating factor exerts dominant effects over macrophage colony stimulating factor during macrophage differentiation in vitro to induce an inflammatory phenotype
BackgroundMacrophages (M φ ) can exist along a spectrum of phenotypes that include pro-inflammatory (M1) or anti-inflammatory (M2) immune cells. M φ ...
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Macrophage subsets and their role: co-relation with colony-stimulating factor-1 receptor and clinical relevance
Macrophages are one of the first innate immune cells to reach the site of infection or injury. Diverse functions from the uptake of pathogen or...
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In vitro effect of granulocyte–macrophage colony-stimulating factor (GM-CSF) on the expression of genes related to sperm motility and energy metabolism and intracytoplasmic sperm injection outcomes in obstructive azoospermic patients
BackgroundThe presence of granulocyte–macrophage colony-stimulating factor (GM-CSF) and its receptor in various testicular cells and spermatozoa...
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Granulocyte–macrophage colony-stimulating factor-containing medium treatment after thawing improves blastocyst-transfer outcomes in the frozen- thawed blastocyst-transfer cycle
PurposeTo determine whether granulocyte–macrophage colony-stimulating factor (GM-CSF)-containing medium could improve embryo-transfer outcomes in...
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A case of granulocyte-colony-stimulating factor-producing gallbladder cancer with lymph node metastasis together with a literature review
The granulocyte-colony-stimulating factor (G-CSF) glycoprotein stimulates precursor cell proliferation and differentiation in the bone marrow....
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Macrophage migration inhibitory factor blockade reprograms macrophages and disrupts prosurvival signaling in acute myeloid leukemia
The malignant microenvironment plays a major role in the development of resistance to therapies and the occurrence of relapses in acute myeloid...
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Synergistic Effect of Human Chorionic Gonadotropin and Granulocyte Colony Stimulating Factor in the Mobilization of HSPCs Improves Overall Survival After PBSCT in a Preclinical Murine Model. Are We Far Enough for Therapy?
Strategies to improve hematopoietic stem and progenitor cell (HSPC) mobilization from the bone marrow can have a pivotal role in addressing...
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Interleukin-6 and granulocyte colony-stimulating factor as predictors of the prognosis of influenza-associated pneumonia
BackgroundPneumonia is a common complication of influenza and closely related to mortality in influenza patients. The present study examines...
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The Effect of Granulocyte Colony-Stimulating Factor on Endometrial Receptivity of Implantation Failure Mouse
AbstractThe purpose of this study was to investigate the effect of G-CSF on the endometrial receptivity of implantation failure mice. Sixty female...
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Titania nanospikes activate macrophage phagocytosis by ligand-independent contact stimulation
Macrophage phagocytosis is an important research target to combat various inflammatory or autoimmune diseases; however, the phenomenon has never been...
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Blockade of tumor-derived colony-stimulating factor 1 (CSF1) promotes an immune-permissive tumor microenvironment
The macrophage colony-stimulating factor 1 (CSF1) is a chemokine essential for the survival, proliferation, and differentiation of mononuclear...
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Autoimmune Pulmonary Alveolar Proteinosis: A Review of Pathogenesis and Emerging Therapies
Purpose of ReviewAutoimmune pulmonary alveolar proteinosis is a heterogenous clinical syndrome of disordered surfactant clearance due to a...
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Tumour-derived CSF2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas
BackgroundMalignant tumours release factors, which attract myeloid cells and induce their polarisation to pro-invasive, immunosuppressive phenotypes....
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Macrophage-Targeted Nanomedicines
Macrophages are versatile cells of the innate immune system responsible for the control and progressions of a variety of autoimmune inflammatory,...
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Macrophage re-programming by JAK inhibitors relies on MAFB
Monocyte-derived macrophages play a key pathogenic role in inflammatory diseases. In the case of rheumatoid arthritis (RA), the presence of specific...
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Macrophage polarization in inflammatory bowel disease
The growing prevalence of inflammatory bowel disease (IBD) has encouraged research efforts, which have contributed to gradual improvements in our...
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The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review
Pulmonary fibrosis (PF) is a progressive interstitial inflammatory disease with a high mortality rate. Patients with PF commonly experience a chronic...
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Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells
Glioblastoma is the most aggressive form of primary brain cancer, with a median survival of 12–15 months. The P2X receptor 7 (P2X7R) is upregulated...
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Peptide Vaccines in Breast Cancer
Peptide vaccination for breast cancer aims to elicit a tumor-specific active immune response, with simple administration and limited toxicity....