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Homologous Recombination Repair Gene Mutations in Prostate Cancer: Prevalence and Clinical Value
Despite advances in our understanding of the molecular landscape of prostate cancer and the development of novel biomarker-driven therapies, the...
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Recombination and Chromosomal Rearrangements
Maintenance of chromosome stability is essential for the survival of all organisms and the transmission of their genetic information. Chromosomes...
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Sexual recombination and temporal gene flow maintain host resistance and genetic diversity
Infectious disease can threaten host populations. Hosts can rapidly evolve resistance during epidemics, with this evolution often modulated by...
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Targeted gene inactivation in Salmonella Typhi by CRISPR/Cas9-assisted homologous recombination
BackgroundTargeted gene inactivation (TGI) is a widely used technique for the study of genes’ functions. There are many different methods for TGI,...
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Generation of a Null Mutation of the toothrin Gene by Targeted Homologous Recombination in Drosophila melanogaster
AbstractThe Drosophila toothrin gene is related to the conserved d4 family of genes that encode specific transcription factors. In previous works,...
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Gene conversion: a non-Mendelian process integral to meiotic recombination
Meiosis is undoubtedly the mechanism that underpins Mendelian genetics. Meiosis is a specialised, reductional cell division which generates haploid...
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Targeted Mutagenesis of Mycobacterium Strains by Homologous Recombination
Targeted mutagenesis by homologous recombination (TMHR) is an efficient allelic exchange mutagenesis for bacterial genome engineering in synthetic...
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Efficient targeted recombination with CRISPR/Cas9 in hybrids of Caenorhabditis nematodes with suppressed recombination
BackgroundHomology-based recombination (HR) is the cornerstone of genetic map**. However, a lack of sufficient sequence homology or the presence of...
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Molecular mechanisms and regulation of recombination frequency and distribution in plants
Key messageRecent developments in understanding the distribution and distinctive features of recombination hotspots are reviewed and approaches are...
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A Positive/Negative Selection Cassette for Red Recombination of BAC Clones
AbstractConventional gene cloning methods always require tedious processes confined by PCR conditions and restriction sites, which might result in a...
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Multi-host infection and phylogenetically diverse lineages shape the recombination and gene pool dynamics of Staphylococcus aureus
BackgroundStaphylococcus aureus can infect and adapt to multiple host species. However, our understanding of the genetic and evolutionary drivers of...
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Route Planning of Flight Diversion Based on Genetic Algorithm and Gene Recombination
In this paper, genetic algorithm and gene recombination algorithm are used to search the optimal path or suboptimal path by constructing the...
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Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events
The current pandemic of COVID-19 is fueled by more infectious emergent Omicron variants. Ongoing concerns of emergent variants include possible...
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Screening Key Sites of Class 2 Integron Integrase that Impact Recombination Efficiency
By capturing and expressing exogenous resistance gene cassettes through site-specific recombination, integrons play important roles in the horizontal...
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Fine-scale contemporary recombination variation and its fitness consequences in adaptively diverging stickleback fish
Despite deep evolutionary conservation, recombination rates vary greatly across the genome and among individuals, sexes and populations. Yet the...
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Combined Use of Unidirectional Site-Specific Recombination System and CRISPR-Cas Systems for Plant Genome Editing
Site-specific recombination (SSR) systems have been extensively used for controlled genome modification in eukaryotic cells, especially for DNA...
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The Role of Extensive Recombination in the Evolution of Geminiviruses
Mutation, recombination and pseudo-recombination are the major forces driving the evolution of viruses by the generation of variants upon which...
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Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells
Extended loop extrusion across the immunoglobulin heavy-chain ( Igh ) locus facilitates V H -DJ H recombination following downregulation of the...
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A novel targeted NGS panel identifies numerous homologous recombination deficiency (HRD)-associated gene mutations in addition to known BRCA mutations
Deleterious mutations in the BRCA1 and BRCA2 genes have significant therapeutic relevance in clinical settings regarding personalized therapy...
