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Degree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature
Determining the cause of focal segmental glomerulosclerosis (FSGS) has crucial implications for evaluating the risk of posttransplant recurrence. The...
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The Effacement and Persistence of Tocobaga, a Native Florida Town
Historical descriptions and archaeological research provide a compelling association of the Native town of Tocobaga with the Safety Harbor site...
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Quantitative Imaging of Podocyte Foot Processes in the Kidney Using Confocal and STED Microscopy
Morphological alterations to the kidney filter, particularly to podocyte foot processes, are seen in most types of glomerular diseases. Due to the...
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Imaging of Infection in the Diabetic Foot
Information derived from imaging studies can play an important role in the management of complicated foot problems in a diabetic patient. This...
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FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy
RAAS inhibition has been the standard treatment for CKD for years because it can reduce proteinuria and hence retard renal function decline, but the...
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A new index for the outcome of focal segmental glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a common pathological form of nephrotic syndrome. This study analyzed the value of pathological lesions...
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Coro2b, a podocyte protein downregulated in human diabetic nephropathy, is involved in the development of protamine sulphate-induced foot process effacement
Podocytes have an important role in the pathogenesis of diabetic nephropathy (DN). Podocyte foot process effacement, mediated largely by the...
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Acute interstitial nephritis caused by ANCA-associated vasculitis: a case based review
Antineutrophil cytoplasmic antibodies (ANCA)–associated vasculitis (AAV) typically manifests as rapidly progressive glomerulonephritis with crescent...
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Clinical features, diagnosis, and management of dasatinib-induced nephrotic syndrome
Knowledge of dasatinib-induced nephrotic syndrome is largely based on case reports. The clinical features of dasatinib-induced nephrotic syndrome are...
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Zyxin is important for the stability and function of podocytes, especially during mechanical stretch
Podocyte detachment due to mechanical stress is a common issue in hypertension-induced kidney disease. This study highlights the role of zyxin for...
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A case of immune complex mediated tubulointerstitial disease and nephrotic syndrome: anti LRP-2 Nephropathy with diffuse podocyte effacement
Anti-LDL Receptor-Related Protein 2 (Anti-LRP2) nephropathy is a rare form of kidney disease that affects the older patients and is characterized...
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Acute interstitial nephritis with podocyte foot-process effacement complicating Plasmodium falciparum infection
BackgroundMalarial acute renal failure (MARF) is a component of the severe malaria syndrome, and complicates 1–5% of malaria infections. This form of...
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Precise clinicopathologic findings for application of genetic testing in pediatric kidney transplant recipients with focal segmental glomerulosclerosis/steroid-resistant nephrotic syndrome
BackgroundEstablishing a molecular genetic diagnosis of focal segmental glomerulosclerosis (FSGS)/steroid-resistant nephrotic syndrome (SRNS) can be...
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Focal Segmental Glomerulosclerosis (FSGS)
Focal segmental glomerulosclerosis is a type of podocytopathy characterized by a focal and segmental increase in the mesangial matrix with scarring...
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Kif21a deficiency leads to impaired glomerular filtration barrier function
The renal glomerulus represents the major filtration body of the vertebrate nephron and is responsible for urine production and a number of other...
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The role of PCSK9 in glomerular lipid accumulation and renal injury in diabetic kidney disease
Aims/hypothesisGlomerular lipid accumulation is a defining feature of diabetic kidney disease (DKD); however, the precise underlying mechanism...
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Quantifiable and reproducible phenotypic assessment of a constitutive knockout mouse model for congenital nephrotic syndrome of the Finnish type
Steroid-resistant nephrotic syndrome (SRNS) is the second most frequent cause of childhood chronic kidney disease. Congenital nephrotic syndrome of...
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Membranous Glomerulopathy (MGN)
Membranous glomerulopathy (MGN) accounts for majority of cases of adult onset nephrotic syndrome and nephrotic range proteinuria in adults. On light...
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CHILKBP protects against podocyte injury by preserving ZO-1 expression
Glomerular diseases afflict millions of people and impose an enormous burden on public healthcare costs worldwide. Identification of potential...
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A possible role of classical complement pathway activation in the pathogenesis of immunoglobulin G nephropathy: a case report
Immunoglobulin G (IgG) nephropathy refers to a rare group of diseases characterized by deposits of IgG in the mesangial region. However, IgG...
