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1. Interaction of NF-κB and FOSL1 drives glioma stemness

   Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor; GBM’s inevitable recurrence suggests that glioblastoma stem cells...

   Vanajothi Ramar, Shanchun Guo, ... Mingli Liu in Cellular and Molecular Life Sciences

   Article Open access 10 June 2024
   

2. TRPM7 transactivates the FOSL1 gene through STAT3 and enhances glioma stemness

   Introduction

   We previously reported that TRPM7 regulates glioma cells’ stemness through STAT3. In addition, we demonstrated that FOSL1 is a response...

   Shanchun Guo, Vanajothi Ramar, ... Mingli Liu in Cellular and Molecular Life Sciences

   Article Open access 29 August 2023
   

3. m⁶A demethylation of FOSL1 mRNA protects hepatoma cells against necrosis under glucose deprivation

   Stress-adaptive mechanisms enabling cancer cells to survive under glucose deprivation remain elusive. N ⁶ -methyladenosine (m ⁶ A) modification plays...

   Chun-Rui Wang, Jun-Hua Gong, ... Guo-Chao Zhong in Cell Death & Differentiation

   Article 18 May 2024
   

4. Transcription Factor FOSL1 Promotes Angiogenesis of Colon Carcinoma by Regulating the VEGF Pathway Through Activating TIMP1

   Angiogenesis is the critical media for tumor growth and migration. Tissue Inhibitor Matrix Metalloproteinase-1 (TIMP1) acts as an oncogene in colon...

   Meng Wang, **an Wang, ... **ng Wen in Biochemical Genetics

   Article 16 December 2023
   

5. HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells

   Background

   Vasculogenic mimicry (VM) is an enigmatic physiological feature that influences blood supply within glioblastoma (GBM) tumors for their...

   Hanting Wang, Yiwen Shi, ... Teng Ma in Cell Biology and Toxicology

   Article Open access 11 June 2024
   

6. Exosome-transmitted FOSL1 from cancer-associated fibroblasts drives colorectal cancer stemness and chemo-resistance through transcriptionally activating ITGB4

   Cancer-associated fibroblasts (CAFs) have been proved to facilitate colorectal cancer (CRC) development, either with boosting chemo-resistance by...

   Shanshan Lin, Bo Zhu in Molecular and Cellular Biochemistry

   Article 09 May 2023
   

7. CircCRIM1 promotes nasopharyngeal carcinoma progression via the miR-34c-5p/FOSL1 axis

   Background

   Nasopharyngeal carcinoma (NPC) is a rare malignancy with multiple risk factors (Epstein–Barr virus, etc.) that seriously threatens the...

   Weifeng He, **angqi Zhou, ... Sanyuan Tang in European Journal of Medical Research

   Article Open access 28 April 2022
   

8. The role of FOSL1 in stem-like cell reprogramming processes

   Cancer stem-like cells (CSCs) have self-renewal abilities responsible for cancer progression, therapy resistance, and metastatic growth. The...

   Valeria Pecce, Antonella Verrienti, ... Paola Paci in Scientific Reports

   Article Open access 19 July 2021
   

9. Silent FOSL1 Enhances the Radiosensitivity of Glioma Stem Cells by Down-Regulating miR-27a-5p

   Since few reports have mentioned the role of FOSL1 in the radiotherapy sensitivity of glioma, this study would dig deep into this aspect. Cancer stem...

   Rong Li, Wuqiang Che, ... Lei Yang in Neurochemical Research

   Article 21 August 2021
   

10. ALKBH5 promotes the progression of infantile hemangioma through regulating the NEAT1/miR-378b/FOSL1 axis

    Our work aims to investigate long non-coding RNA (lncRNA) N6-methyladenosine (m ⁶ A) modification and its role in infantile hemangioma (IH). The mRNA...

    Kun Peng, Ren-Peng **a, ... Chong-Gao Zhou in Molecular and Cellular Biochemistry

    Article 18 February 2022
    

11. Fosl1 is vital to heart regeneration upon apex resection in adult Xenopus tropicalis

    Cardiovascular disease is the leading cause of death in the world due to losing regenerative capacity in the adult heart. Frogs possess remarkable...

    Hai-Yan Wu, Yi-Min Zhou, ... Xu-Feng Qi in npj Regenerative Medicine

    Article Open access 29 June 2021
    

12. FOSL1 is a novel mediator of endotoxin/lipopolysaccharide-induced pulmonary angiogenic signaling

    Systemic sepsis is a known risk factor for bronchopulmonary dysplasia (BPD) in premature infants, a disease characterized by dysregulated...

    Christopher R. Nitkin, Sheng **a, ... Venkatesh Sampath in Scientific Reports

    Article Open access 04 August 2020
    

13. TIF1β activates leukemic transcriptional program in HSCs and promotes BCR::ABL1-induced myeloid leukemia

    TIF1β/KAP1/TRIM28, a chromatin modulator, both represses and activates the transcription of genes in normal and malignant cells. Analyses of datasets...

    Mariko Morii, Sho Kubota, ... Goro Sashida in Leukemia

    Article 11 May 2024
    

14. AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma

    Increasing evidence indicates that long non-coding RNAs (lncRNAs) play vital roles in the tumorigenesis and progression of cancers. However, the...

    Shi-Wei He, Cheng Xu, ... Na Liu in Oncogene

    Article Open access 13 July 2020
    

15. Loss of function of GATA3 regulates FRA1 and c-FOS to activate EMT and promote mammary tumorigenesis and metastasis

    Basal-like breast cancers (BLBCs) are among the most aggressive cancers, partly due to their enrichment of cancer stem cells (CSCs). Breast CSCs can...

    **ong Liu, Feng Bai, ... **n-Hai Pei in Cell Death & Disease

    Article Open access 23 June 2023
    

16. Genetic Programs Between Steroid-Sensitive and Steroid-Insensitive Interstitial Lung Disease

    The effectiveness of corticosteroids (GCs) varies greatly in interstitial lung diseases (ILDs). In this study, we aimed to compare the gene...

    Yanjiao Lu, Kun Tang, ... Jungang **e in Inflammation

    Article Open access 10 August 2023
    

17. Identifying novel interactions of the colon-cancer related APC protein with Wnt-pathway nuclear transcription factors

    Background

    Colon cancer is often driven by mutations of the adenomatous polyposis coli (APC) gene, an essential tumor suppressor gene of the Wnt...

    Nayra M. Al-Thani, Stephanie Schaefer-Ramadan, ... Joel A. Malek in Cancer Cell International

    Article Open access 01 December 2022
    

18. Silencing AHNAK promotes nasopharyngeal carcinoma progression by upregulating the ANXA2 protein

    Purpose

    Nasopharyngeal carcinoma (NPC) is an aggressive head and neck disease with a high incidence of distant metastases. Enlargeosomes are...

    **ngxing Lu, Yan Mei, ... Mei Yi in Cellular Oncology

    Article 14 November 2023
    

19. Shared metabolic shifts in endothelial cells in stroke and Alzheimer’s disease revealed by integrated analysis

    Since metabolic dysregulation is a hallmark of both stroke and Alzheimer’s disease (AD), mining shared metabolic patterns in these diseases will help...

    Guangyu Guo, Liyuan Fan, ... Yuming Xu in Scientific Data

    Article Open access 29 September 2023
    

20. UBAP2 plays a role in bone homeostasis through the regulation of osteoblastogenesis and osteoclastogenesis

    Osteoporosis is a condition characterized by decreased bone mineral density (BMD) and reduced bone strength, leading to an increased risk of...

    Jeonghyun Kim, Bo-Young Kim, ... Seon-Yong Jeong in Nature Communications

    Article Open access 20 June 2023