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High plasma levels of endosialin and cardiovascular events in patients undergoing coronary angiography
Endosialin, also known as tumor endothelial marker-1, is a transmembrane glycoprotein that plays a role in inflammation and tumor progression....
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Endosialin-positive tumor-derived pericytes promote tumor progression through impeding the infiltration of CD8+ T cells in clear cell renal cell carcinoma
BackgroundImmune checkpoint blockade (ICB) therapy can be effective against clear cell renal cell carcinoma (ccRCC), but many patients show no...
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TEM1/endosialin/CD248 promotes pathologic scarring and TGF-β activity through its receptor stability in dermal fibroblasts
BackgroundPathologic scars, including keloids and hypertrophic scars, represent a common form of exaggerated cutaneous scarring that is difficult to...
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Metabolic consequences for mice lacking Endosialin: LC–MS/MS-based metabolic phenoty** of serum from C56Bl/6J Control and CD248 knock‐out mice
IntroductionThe Endosialin/CD248/TEM1 protein is expressed in adipose tissue and its expression increases with obesity. Recently, genetic deletion of...
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Preclinical Evaluation and Dosimetry of [111In]CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1)
PurposeEndosialin/tumor endothelial marker-1 (TEM1) is an attractive theranostic target expressed by the microenvironment of a wide range of tumors,...
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Group XIV C-type lectins: emerging targets in tumor angiogenesis
C-type lectins, distinguished by a C-type lectin binding domain (CTLD), are an evolutionarily conserved superfamily of glycoproteins that are...
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A phase I study of ontuxizumab, a humanized monoclonal antibody targeting endosialin, in Japanese patients with solid tumors
Background We conducted a first-in-Japanese, phase I study of ontuxizumab, a humanized, anti-endosialin monoclonal antibody, to confirm its...
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Role of C-Type Lectins in the Tumor Microenvironment
C-type lectin receptors (CLRs) represent a broad and diversified family of pattern recognition receptors (PRRs) that are mainly expressed on the...
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Correction to: Preclinical Evaluation and Dosimetry of [111In] CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1)
In the original article, some numerical values in the following paragraph were reported incorrectly.
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On the origin and development of glioblastoma: multifaceted role of perivascular mesenchymal stromal cells
Glioblastoma, IDH wild-type is the most common and aggressive form of glial tumors. The exact mechanisms of glioblastoma oncogenesis, including the...
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CD248 promotes migration and metastasis of osteosarcoma through ITGB1-mediated FAK-paxillin pathway activation
BackgroundOsteosarcoma (OS) is the most common malignant bone tumor with a high incidence in children and adolescents. Frequent tumor metastasis and...
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Quantitative urine proteomics in pregnant women for the identification of predictive biomarkers for preeclampsia
BackgroundPreeclampsia (PE) is a life-threatening disease characterized by elevated blood pressure and proteinuria. Predictive biomarkers of PE are...
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Blood-Retinal Barrier Development and Potential for Regeneration in Blinding Eye Disease
The blood-retinal barrier (BRB) creates the defined retinal environment necessary for neuronal signaling and vision. The well-developed tight...
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Advances of cancer-associated fibroblasts in liver cancer
Liver cancer is one of the most common malignant tumors worldwide, it is ranked sixth in incidence and fourth in mortality. According to the distinct...
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Novel therapeutic strategies for injured endometrium: intrauterine transplantation of menstrual blood‑derived cells from infertile patients
BackgroundMenstrual blood-derived cells show regenerative potential as a mesenchymal stem cell and may therefore be a novel stem cell source of...
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CD248-expressing cancer-associated fibroblasts induce epithelial–mesenchymal transition of non-small cell lung cancer via inducing M2-polarized macrophages
Non-small cell lung cancer (NSCLC)-originating cancer-associated fibroblasts (CAFs) expressing CD248 regulate interaction with immune cells to...
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The Role of Pericytes in Tumor Angiogenesis
Pericytes are branched cells surrounded by the basement membrane (BM) of capillaries and post-capillary venules. Pericytes are involved in the...
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Characterization of the Biological Response to Scaffolds
Characterizing the biological responseBiological response of biomaterialsBiomaterials, scaffoldsScaffold or medical devices is crucial to...
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Molecular Phenotypes of Endothelial Cells in Malignant Tumors
Angiogenesis is an essential process for tumor growth, progression, and metastasis, and it is one of the hallmarks of cancer. In addition to being...