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Dual inhibitors of DNMT and HDAC induce viral mimicry to induce antitumour immunity in breast cancer
The existing conventional treatments for breast cancer, including immune checkpoint blockade, exhibit limited effects in some cancers, particularly...
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Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation
During embryo development, DNA methylation is established by DNMT3A/3B and subsequently maintained by DNMT1. While much research has been done in...
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The maternal effects of dietary restriction on Dnmt expression and reproduction in two clones of Daphnia pulex
The inheritance of epigenetic marks induced by environmental variation in a previous generation is broadly accepted as a mediator of phenotypic...
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DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts
Immunotherapies targeting cancer-specific neoantigens have revolutionized the treatment of cancer patients. Recent evidence suggests that epigenetic...
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Altered DNA methylation and Dnmt expression in obese uterus may cause implantation failure
Obesity is defined by increased adipose tissue volume and has become a major risk factor for reproduction. Recent studies have revealed a substantial...
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Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury
The purpose of this study was to investigate whether inhibition of DNA (cytosine-5)-methyltransferase 1 (DNMT-1) alleviated ferroptosis through...
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DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors
Role of DNA damage and demethylation on anticancer activity of DNA methyltransferase inhibitors (DNMTi) remains undefined. We report the effects of DNMT1...
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miR-497-5p/SALL4 axis promotes stemness phenotype of choriocarcinoma and forms a feedback loop with DNMT-mediated epigenetic regulation
Choriocarcinoma stem-like cells (CSLCs) might be at the origin of choriocarcinoma development associated with drug resistance or relapse. Spalt-like...
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Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling
Patients with long-standing diabetes have a high risk for cardiac complications that is exacerbated by increased reactive oxygen species (ROS)...
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Identification of Novel Peptides Targeting DNA Methyltransferase 1 (DNMT-1) for Breast Cancer Treatment
Epigenetic alteration shows an essential role in the process of breast cancer cell proliferation and propagation. DNA methyltransferase (DNMT) is...
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Epigenetic Processes of DNA Methylation Are Selectively Involved in the Mechanisms of Retrograde and Anteograde Amnesia
The participation of DNA methylation processes in the mechanisms of anterograde and retrograde amnesia caused by impaired reconsolidation of...
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The loss of global DNA methylation due to decreased DNMT expression in the postnatal mouse ovaries may associate with infertility emerging during ovarian aging
Ovarian aging is one of the main causes of female infertility, and its molecular background is still largely unknown. As DNA methylation regulates...
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Genomic targets and selective inhibition of DNA methyltransferase isoforms
BackgroundDNA methylation in the human genome is established and maintained by DNA methyltransferases (DNMTs). DNMT isoforms show differential...
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Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis
Sepsis is defined as a life-threatening organ dysfunction caused by an inappropriate host response to infection. The presence of oxidative stress and...
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Prenatal Stress Induces Long-Term Behavioral Sex-Dependent Changes in Rats Offspring: the Role of the HPA Axis and Epigenetics
Preclinical genetic studies have related stress early exposures with changes in gene regulatory mechanisms, including epigenetic alterations, such as...
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Epigenetic silencing of LDHB promotes hepatocellular carcinoma by remodeling the tumor microenvironment
Lactate dehydrogenase B (LDHB) reversibly catalyzes the conversion of pyruvate to lactate or lactate to pyruvate and expressed in various...
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Alterations in DNA methylation machinery in a rat model of osteoarthritis of the hip
BackgroundThis study aimed to validate alterations in the gene expression of DNA methylation-related enzymes and global methylation in the peripheral...
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Distinct global DNA methylation and NF-κB expression profile of preimplantation biopsies from ideal and non-ideal kidneys
BackgroundEpigenetic mechanisms may affect the ideal and non-ideal kidneys selected for transplantation and their inflammatory gene expression...
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Transcriptional alterations of protein coding and noncoding RNAs in triple negative breast cancer in response to DNA methyltransferases inhibition
BackgroundDNA methylation plays a crucial role in multiple cellular processes such as gene regulation, chromatin stability, and genetic imprinting....
