Search
Search Results
-
Targeting the DNA Damage Response for Cancer Therapy
This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and...
-
Absolute quantification of DNA damage response proteins
BackgroundDNA damage response (DDR) and repair are vital for safeguarding genetic information and ensuring the survival and accurate transmission of...
-
Distinct characteristics of the DNA damage response in mammalian oocytes
DNA damage is a critical threat that poses significant challenges to all cells. To address this issue, cells have evolved a sophisticated molecular...
-
Chromatin compartmentalization regulates the response to DNA damage
The DNA damage response is essential to safeguard genome integrity. Although the contribution of chromatin in DNA repair has been investigated
1 ,2 ,...
-
ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway
The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate...
-
The DNA damage sensor ATM kinase interacts with the p53 mRNA and guides the DNA damage response pathway
BackgroundThe ATM kinase constitutes a master regulatory hub of DNA damage and activates the p53 response pathway by phosphorylating the MDM2...
-
p53-dependent DNA repair during the DNA damage response requires actin nucleation by JMY
The tumour suppressor p53 is a nuclear transcription factor with key roles during DNA damage to enable a variety of cellular responses including cell...
-
Map** combinatorial drug effects to DNA damage response kinase inhibitors
One fundamental principle that underlies various cancer treatments, such as traditional chemotherapy and radiotherapy, involves the induction of...
-
Pollutant-Induced DNA Damage
The presence of pollutants in our environment has become a significant concern for human health and well-being. Numerous studies have shown a strong...
-
Emerging posttranslational modifications and their roles in DNA damage response
Posttranslational modifications (PTMs), occurring on various histones and nonhistone proteins, greatly enrich the diversity of the proteome, thereby...
-
DNA Damage Responses Methods and Protocols
This volume provides detailed methods and key approaches used to mechanistically study DNA damage, as well as the factors involved in the damage...
-
Involvement of H2A variants in DNA damage response of zygotes
Phosphorylated H2AX, known as γH2AX, forms in response to genotoxic insults in somatic cells. Despite the high abundance of H2AX in zygotes, the...
-
Multifaceted roles of CCAR family proteins in the DNA damage response and cancer
The cell cycle apoptosis regulator (CCAR) family of proteins consists of two proteins, CCAR1 and CCAR2, that play a variety of roles in cellular...
-
SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation
The SUMO protease SENP6 maintains genomic stability, but mechanistic understanding of this process remains limited. We find that SENP6 deconjugates...
-
A new wave of innovations within the DNA damage response
Genome instability has been identified as one of the enabling hallmarks in cancer. DNA damage response (DDR) network is responsible for maintenance...
-
A DNA-PK phosphorylation site on MET regulates its signaling interface with the DNA damage response
The DNA damage response (DDR) is intertwined with signaling pathways downstream of oncogenic receptor tyrosine kinases (RTKs). To drive research into...
-
DNA Damage and DNA Repair
This chapter describes in more detail the various kinds of DNA damage that can cause mutations and chromosomal alterations as well as the...
-
Crosstalk between immune checkpoint and DNA damage response inhibitors for radiosensitization of tumors
PurposeThis review article is intended to provide a perspective overview of potential strategies to overcome radiation resistance of tumors through...
-
Zeocin-induced DNA damage response in barley and its dependence on ATR
DNA damage response (DDR) is an essential mechanism by which living organisms maintain their genomic stability. In plants, DDR is important also for...
-
The DNA Damage Checkpoint
The DNA damage response (DDR), also known as the DNA damage checkpoint (DNADC) acts to prevent cells with damaged DNA from entering mitosis. Kinds of...