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1. Carnitine Palmitoyltransferase Deficiency

   Deficiencies of carnitine palmitoyltransferases (CPT) 1 and 2 are inborn errors of carnitine metabolism. CPT1 and CPT2 are integral components of the...

   Udara D. Senarathne, Shilpa Bhardwaj, ... James Pitt in Genetic Syndromes

   Living reference work entry 2023
   

2. A novel pathogenic variant in the carnitine transporter gene, SLC22A5, in association with metabolic carnitine deficiency and cardiomyopathy features

   Background

   Primary carnitine deficiency (PCD) denotes low carnitine levels with an autosomal recessive pattern of inheritance. Cardiomyopathy is the...

   Amir Ghaffari Jolfayi, Niloofar Naderi, ... Samira Kalayinia in BMC Cardiovascular Disorders

   Article Open access 02 January 2024
   

3. Impact of 1α,25-dihydroxyvitamin D₃ on biodistribution and pharmacokinetics of L-carnitine and creatinine, organic cation/carnitine transporter 2 and organic cation transporter 2 biomarkers

   Purpose

   This study investigated effects of 1α,25-dihydroxyvitamin D ₃ [1,25(OH) ₂ D ₃ ] on biodistribution and pharmacokinetics of L-carnitine and...

   Dang-Khoa Vo, Thi-Thao-Linh Nguyen, Han-Joo Maeng in Journal of Pharmaceutical Investigation

   Article 07 February 2024
   

4. L-carnitine and Acetyl-L Carnitine: A Possibility for Treating Alterations Induced by Obesity in the Central Nervous System

   Excessive consumption of nutrients, as well as obesity, leads to an inflammatory process, especially in adipose tissue. This inflammation reaches the...

   Larissa Espindola da Silva, Mariana Pacheco de Oliveira, ... Gislaine Tezza Rezin in Neurochemical Research

   Article 27 July 2023
   

5. Carnitine modulates antioxidative defense in ABI2 mutant under salt stress

   Carnitine, a ubiquitous compound in living organisms, fulfills diverse roles in energy metabolism, stress resilience, and detoxification. Its...

   Azime Gokce, Askim Hediye Sekmen Cetinel, Ismail Turkan in Plant Growth Regulation

   Article Open access 13 June 2024
   

6. Genetic inactivation of the Carnitine/Acetyl-Carnitine mitochondrial carrier of Yarrowia lipolytica leads to enhanced odd-chain fatty acid production

   Background

   Mitochondrial carriers (MCs) can deeply affect the intracellular flux distribution of metabolic pathways. The manipulation of their...

   Eugenia Messina, Camilla Pires de Souza, ... Gennaro Agrimi in Microbial Cell Factories

   Article Open access 13 July 2023
   

7. Association between plasma L-carnitine levels and mitochondrial DNA copy number

   Mitochondria are key cytoplasmic organelles in eukaryotic cells that generate adenosine triphosphate (ATP) through the electron transport chain and...

   Mingyue Li, Keming Yang, ... Jiali Han in BMC Molecular and Cell Biology

   Article Open access 11 December 2023
   

8. Anti-pruritic effect of L-carnitine against chloroquine-induced pruritus mediated via nitric oxide pathway

   Background

   Pruritus, or itching, is a distressing symptom associated with various dermatological and systemic diseases. L-carnitine (βeta...

   Kiran Seemab, Arif-ullah Khan, ... Fawad Ali in BMC Pharmacology and Toxicology

   Article Open access 22 May 2024
   

9. L-carnitine promotes liver regeneration after hepatectomy by enhancing lipid metabolism

   Background

   Lipid metabolism plays an important role in liver regeneration, but its regulation still requires further research. In this study, lipid...

   ** Zhou, Guobin Huang, ... Bo Yang in Journal of Translational Medicine

   Article Open access 20 July 2023
   

10. Combination of Gold Nanoparticles with Carnitine Attenuates Brain Damage in an Obesity Animal Model

    Obesity causes inflammation in the adipose tissue and can affect the central nervous system, leading to oxidative stress and mitochondrial...

    Larissa Espindola da Silva, Jessica Silva Abel, ... Gislaine Tezza Rezin in Molecular Neurobiology

    Article 01 February 2024
    

11. L-carnitine decreases myocardial injury in children undergoing open-heart surgery: A randomized controlled trial

    Abstract

    Myocardial injury in open-heart surgery is related to several factors including ischemia–reperfusion injury, generation of reactive oxygen...

    Wael El Feky, Dalia El-Afify, ... Doaa El Amrousy in European Journal of Pediatrics

    Article Open access 03 April 2024
    

12. Application of gold-nickel nanoparticle alloy sensors in measuring L-carnitine content in sports nutritional foods

    This research presents the development of a gold-nickel (Au-Ni) nanoparticle alloy sensor for accurately quantifying L-carnitine in sports...

    Yufei Han, Yani Kong, ... Shuze Sun in Journal of Food Measurement and Characterization

    Article 10 June 2024
    

13. The efficacy of L-carnitine in patients with nonalcoholic steatohepatitis and concomitant obesity

    Background

    In light of the high prevalence of nonalcoholic fatty liver disease and obesity, treatment options for nonalcoholic steatohepatitis are of...

    Natalia Zakharova, Chenguang Luo, ... Vadim Samusenkov in Lipids in Health and Disease

    Article Open access 12 July 2023

14. Secondary carnitine deficiency during refeeding in severely malnourished patients with eating disorders: a retrospective cohort study

    Background

    Secondary carnitine deficiency in patients with anorexia nervosa has been rarely reported. This study aimed to investigate the occurrence...

    Miho Imaeda, Satoshi Tanaka, ... Norio Ozaki in Journal of Eating Disorders

    Article Open access 09 July 2024
    

15. Water stress and exogenous carnitine on growth and essential oil profile of Eryngium foetidum L.

    Water stress influences plant growth and metabolism. Carnitine, an amino acid involved in lipid metabolism, has been related to responses of plants...

    Sabrina Kelly dos Santos, Daniel da Silva Gomes, ... Diego Silva Batista in 3 Biotech

    Article 02 September 2023
    

16. Incidence of atrial fibrillation after esophageal cancer surgery with L-carnitine use: a preliminary single-group interventional study

    Purpose

    We aimed to investigate the POAF rate and blood FABP4 levels after perioperative L-carnitine administration in patients with esophageal cancer.

    ...

    Yasushige Shingu, Isao Yokota, ... Satoru Wakasa in Surgery Today

    Article 23 February 2024
    

17. Drought stress mitigation by foliar application of L-carnitine and its effect on radish morphophysiology

    Drought is the major abiotic stress limiting crop production worldwide, with drought events being expected to be harsher and more frequent due to the...

    Juliane Maciel Henschel, Estephanni Fernanda Oliveira Dantas, ... Diego Silva Batista in Physiology and Molecular Biology of Plants

    Article 24 April 2023
    

18. Efficacy and safety of carnitine supplementation on NAFLD: a systematic review and meta-analysis

    Background and objective

    The efficacy and safety of L-carnitine supplementation on non-alcoholic fatty liver disease (NAFLD) are unclear. This...

    Ai** Liu, Yitong Cai, ... **zu Jiao in Systematic Reviews

    Article Open access 29 April 2023
    

19. Distinguishing benign and malignant thyroid nodules using plasma trimethylamine N-oxide, carnitine, choline and betaine

    Purpose

    Trimethylamine N-oxide (TMAO), a gut microbiome–derived metabolite, and its precursors (carnitine, choline, betaine) have not been fully...

    Liang Shi, Muhong Guo, ... Fei Yu in Journal of Cancer Research and Clinical Oncology

    Article Open access 20 March 2024
    

20. One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse

    The increasing availability of experimental and computational protein structures entices their use for function prediction. Here we develop an...

    Marco Malatesta, Emanuele Fornasier, ... Riccardo Percudani in Nature Communications

    Article Open access 13 April 2024