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Learning from cerebrospinal fluid drug-resistant HIV escape-associated encephalitis: a case report
BackgroundIn the era of antiretroviral therapy (ART), central nervous system (CNS) complications in patients with human immunodeficiency virus (HIV)...
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P4HA3 promotes colon cancer cell escape from macrophage phagocytosis by increasing phagocytosis immune checkpoint CD47 expression
Cancer immunotherapies have greatly changed the prospects for the therapy of many malignancies, including colon cancer. Macrophages as the effectors...
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Immune Escape Mechanism of Cancer
Purpose of ReviewCancer immune evasion is still a major obstacle in elimination of cancer cells and current cancer treatment. This review focuses on...
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Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R
Acquired drug resistance poses a challenge for single-target FGFR inhibitors, leading to the development of dual- or multi-target FGFR inhibitors....
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TP53 to mediate immune escape in tumor microenvironment: an overview of the research progress
Increasing evidence suggests that key cancer-causing driver genes continue to exert a sustained influence on the tumor microenvironment (TME),...
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Galectin-3 and cancer immunotherapy: a glycobiological rationale to overcome tumor immune escape
Immunotherapy with checkpoint inhibitors (ICIs) has radically changed the landscape of therapeutic opportunities in oncology, but much still needs to...
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TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice
Acute systemic inflammation critically alters the function of the immune system, often promoting myelopoiesis at the expense of lymphopoiesis. In the...
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Liquorpheresis and Related CSF Management Systems: Definitions, Systems, Procedures, and Complications
This chapter covers the different mechanical techniques employed for filtering cerebrospinal fluid (CSF), and other CSF management systems that can...
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CSF Leakage and Its Management
Cerebrospinal fluid (CSF) leakage can occur during cochlear implant surgery in inner ear malformations. It is most common in incomplete partition...
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CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response
BackgroundThe Alzheimer’s disease (AD) risk gene ABCA7 has suggested functions in lipid metabolism and the immune system. Rare premature termination...
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Dengue virus co-opts innate type 2 pathways to escape early control of viral replication
Mast cell products and high levels of type 2 cytokines are associated with severe dengue disease. Group 2 innate lymphoid cells (ILC2) are type-2...
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Investigation of the immune escape mechanism of Treponema pallidum
BackgroundSyphilis is a chronic sexually transmitted disease caused by Treponema pallidum subspecies pallidum ( T. pallidum ), which is a public...
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M-CSF as a therapeutic target in BRAFV600E melanoma resistant to BRAF inhibitors
BackgroundDisseminated BRAF V600E melanoma responds to BRAF inhibitors (BRAFi) but easily develops resistance with poor prognosis. Secretome plays a...
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Cerebrospinal fluid pleocytosis as a predictive factor for CSF and plasma HIV RNA discordance and escape
The aims of this study were to investigate the frequency of HIV-1 RNA level discordance between the cerebrospinal fluid (CSF) and plasma and of CSF...
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Tumor-associated macrophage-derived exosomes LINC01592 induce the immune escape of esophageal cancer by decreasing MHC-I surface expression
BackgroundTAMs (tumor-associated macrophages) infiltration promotes the progression of esophageal cancer (EC). However, the underlying mechanisms...
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Relapse of Symptomatic Cerebrospinal Fluid HIV Escape
Purpose of ReviewSymptomatic cerebrospinal fluid (CSF) HIV escape defines the presence of neurological disease in combination antiretroviral therapy...
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Inter-Code Comparison Exercise for Predicting Transient Helium Distribution in a Scale Down Containment Facility, CSF
In case of severe accident in water-cooled nuclear power reactors, hydrogen may get released into the nuclear containment due to metal–water...
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Prognostic significance and immune escape implication of tumor-infiltrating neutrophil plasticity in human head and neck squamous cell carcinoma
Tumor-infiltrating neutrophils play a crucial role in the progression of head and neck squamous cell carcinoma (HNSCC). Here, we aimed to...
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Numerical Studies to Assess the Effect of Simulated Recombiner on Helium Distribution and Mixing in a Scale Down Containment Facility, CSF
Hydrogen may get released into the containment building during postulated severe accident conditions in nuclear power plants (NPPs). Effective...
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Cancer Immunoediting: Elimination, Equilibrium, and Immune Escape in Solid Tumors
Emphasizing the dynamic processes between cancer and host immune system, the initially discovered concept of cancer immunosurveillance has been...