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Antiseizure Medications
Epilepsy and status epilepticus (SE) are both common neurologic disease states encountered in any neurocritical care unit and require aggressive...
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Black-Box Warnings of Antiseizure Medications: What is Inside the Box?
Antiseizure medications can cause serious adverse reactions and have deleterious drug interactions that often complicate the clinical management of...
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Neurobehavioral Outcomes of Children with Antenatal Exposure to Antiseizure Medications
ObjectivesTo evaluate the effect of antiepileptic medications prescribed to mothers during pregnancy on the development and behavior of children.
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Growth-related effects of antiseizure medications are of concern in children with epilepsy
Epilepsy is a common chronic neurological condition in children that is treated with antiseizure medications as first-line (and subsequent-line)...
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Presynaptic antiseizure medications - basic mechanisms and clues for their rational combinations
Among clinically highly efficient antiseizure medications (ASMs) there are modifiers of the presynaptic release machinery. Of them, levetiracetam and...
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Thromboembolic Risks with Concurrent Direct Oral Anticoagulants and Antiseizure Medications: A Population-Based Analysis
Background and ObjectiveDrug–drug interactions between direct oral anticoagulants (DOAC) and antiseizure medications via the cytochrome P450 (CYP) or...
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Interactions Between Direct Oral Anticoagulants (DOACs) and Antiseizure Medications: Potential Implications on DOAC Treatment
The use of direct oral anticoagulants (DOACs) is increasing because of their superior efficacy and safety compared with vitamin K antagonists....
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Sex Differences in Adverse Effects of Antiseizure Medications in Adults with Epilepsy: A Systematic Review
BackgroundSex differences in epilepsy have been described in prevalence, seizure propensity and response to treatment. Therefore, taking into account...
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Newer Antiseizure Medications and Suicidality: Analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS) Database
BackgroundThe association between antiseizure medications (ASMs) and suicidality remains controversial. Analyses of additional datasets are needed to...
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Antiseizure medications for idiopathic generalized epilepsies: a systematic review and network meta-analysis
ObjectivesTo compare the efficacy and safety of antiseizure medications (ASMs), both as monotherapies and adjunctive therapies, for idiopathic...
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The Effect of Levetiracetam Compared with Enzyme-Inducing Antiseizure Medications on Apixaban and Rivaroxaban Peak Plasma Concentrations
Background and ObjectivePost-stroke epilepsy represents an important clinical challenge as it often requires both treatment with direct oral...
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Efficacy and Safety of Five Broad-Spectrum Antiseizure Medications for Adjunctive Treatment of Refractory Epilepsy: A Systematic Review and Network Meta-analysis
BackgroundOverall, up to one-third of epilepsy patients have drug-resistant epilepsy. However, there was previously no meta-analysis to support the...
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Pilot study on the probability of drug-drug interactions among direct oral anticoagulants (DOACs) and antiseizure medications (ASMs): a clinical perspective
Abstract BackgroundThere is little and controversial information about changes in plasma concentrations (PCs) or clinical events during...
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Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic–clonic seizure model: an isobolographic transformation
BackgroundOverwhelming evidence indicates that some naturally occurring coumarins and terpenes are widely used in folk medicine due to their various...
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Impact of Antiseizure Medications on Appetite and Weight in Children
There are numerous potential factors that may affect growth in children with epilepsy, and these must be evaluated in any child with appetite and...
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Imperatorin interacts additively with novel antiseizure medications in the mouse maximal electroshock-induced seizure model: an isobolographic transformation
BackgroundAnticonvulsant effects of imperatorin (IMP) have been experimentally confirmed earlier, but no information is available on the interaction...
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Efficacy and Tolerability of Adjunctive Brivaracetam in Patients with Focal-Onset Seizures on Specific Concomitant Antiseizure Medications: Pooled Analysis of Double-Blind, Placebo-Controlled Trials
IntroductionThis article aimed to assess the efficacy and tolerability of adjunctive brivaracetam (BRV) in adults with focal-onset seizures on...
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A pilot study on identifying gene signatures as markers for predicting patient response to antiseizure medications
The majority of the biomarkers were associated with the diagnosis of epilepsy and few of them can be applied to predict the response to antiseizure...
