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Antimycobacterial, antibiofilm and efflux pump inhibitory activity of extracts from selected Combretum species used in traditional medicine in Zimbabwe
Non-tuberculous mycobacteria infect mostly immunocompromised people. NTM infections incidence and prevalence increase has led to a public health...
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Investigation of the antimycobacterial activity of African medicinal plants combined with chemometric analysis to identify potential leads
The emergence of drug-resistant Mycobacterium tuberculosis strains is a threat to global health necessitating the discovery of novel chemotherapeutic...
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Synthesis and Antimycobacterial Activity of Some New Pyrazinamide Derivatives
Some pyrazinamide derivatives ( 2a-2e, 2a′-2e′ , and 2a″-2e″ ) were synthesized and evaluated as antimycobacterial agents against Mycobacterium...
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Penicillium: A Treasure Trove for Antimycobacterial and Antioxidant Metabolites
Penicillium, belonging to the phylum Ascomycota, is one of the most studied genera for its therapeutic properties. Based on ascocarps, it can be...
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Synthesis, Characterization and Antimycobacterial Activity of Some Substituted Phenylpyridazinone Derivatives
Aseries 6-phenyl-2-(substituted methyl)-dihydropyridazinone derivatives ( 3a – 3f ) were synthesized using the interaction of 6-phenylpyridazinone with...
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New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239
During our screening for anti-mycobacterial agents against Mycobacterium avium complex (MAC), two new polycyclic tetramate macrolactams (PTMs), named...
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Fungal-derived compounds and mycogenic nanoparticles with antimycobacterial activity: a review
Tuberculosis (TB) is a persistent lung infection caused by Mycobacterium tuberculosis . The disease is characterized by high mortality rates of over 1...
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Deciphering the antimycobacterial, cytotoxicity and phytochemical profile of Entada abyssinica stem bark
Organic (acetonic, chloroform, methanolic and hexanic) extracts of Entada abyssinica stem bark were screened for their antimycobacterial,...
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Screening of Actinobacterial Extracts/Compounds for Antimycobacterial Activity by Luciferase Reporter Phage (LRP) Assay
Actinomycetes were tested for antimicrobial and antimycobacterial activity with less known habitats. Crude extracts have been evaluated against...
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Screening of Actinobacterial Cultures for Antimycobacterial Activity Using Mycobacterium smegmatis
Tuberculosis (TB) is a significant threat to public health and infectious disease caused by mycobacterium (MTB). In addition, some non-tuberculous...
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In Silico Docking Studies, Synthesis, Characterization, and Antimicrobial Antimycobacterial Activity of Coumarinyl Oxadiazoles from Fatty Acids
AbstractThis present study deals with the design and evaluation of novel coumarinyl oxadiazoles substituted fatty acids derivatives using synthetic...
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Discovery of potent antimycobacterial agents targeting lumazine synthase (RibH) of Mycobacterium tuberculosis
Tuberculosis (TB) continues to be a global health crisis, necessitating urgent interventions to address drug resistance and improve treatment...
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Antimicrobial Peptides as Immunomodulators and Antimycobacterial Agents to Combat Mycobacterium tuberculosis: a Critical Review
Tuberculosis (TB) is a devastating disease foisting a significantly high morbidity, prepotent in low- and middle-income develo** countries....
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Exploring the Therapeutic Potential of Wild Edible Mushrooms: Safety Evaluation and Isolation of Antimycobacterial Sterols from Afrocantharellus platyphyllus (Heinem.) Tibuhwa
PurposeAfrocantharellus platyphyllus (Heinem.) Tibuhwa (family Cantharellaceae) is a wild mushroom that is used for food and in the management of...
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Synthesis and In-Vitro Antimycobacterial Evaluation of 4-Arylidene-2-Phenyl-6-(Aryl)-4,5-Dihydropyridazin-3(2H)-One Derivatives
A series of 4-arylidene-2-phenyl-6-(aryl)-4,5-dihydropyridazin-3( 2H )-one derivatives ( 3a–3g and 3a’–3g’ ) have been synthesized and evaluated as...
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Antimycobacterial Evaluation and Microwave-Assisted Synthesis of N-(5-methyl-4-oxo-2-arylthiazolidin-3-yl) Isonicotinamide Derivatives
Thiazolidinone derivatives represent heterocyclic bioactive compounds. We have synthesized some...
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Controlled synthesis of Ag/CuO nanocomposites: evaluation of their antimycobacterial, antioxidant, and anticancer activities
Herein we summarize the production of silver/copper oxide nanocomposites (Ag/CuO NCs) by a facile solution combustion method with the aid of...
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Phytochemical screening, antimycobacterial activity and acute toxicity of crude extracts of selected medicinal plant species used locally in the treatment of tuberculosis in Uganda
BackgroundTuberculosis (TB) is one of the leading causes of death globally, and the rise in drug-resistant forms of TB has become a significant...
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In-silico and in-vitro analysis of novel substituted benzimidazolyl derivatives for antimycobacterial potentials targeting enoyl acyl carrier protein reductase (InhA)
BackgroundThe emergence of mutated drug-resistant strains of Mycobacterium tuberculosis has reinvigorated the development of effective chemotherapy...
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Prospects of Using Pharmacologically Active Compounds for the Creation of Antimycobacterial Drugs
The growth of resistance to antimycobacterial drugs dictates the need to develop new agents with high therapeutic efficacy and low toxicity. The...
