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Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification
Creating long-lasting memories requires learning-induced changes in gene expression, which are impacted by epigenetic modifications of DNA and...
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Targeting alternative splicing as a new cancer immunotherapy-phosphorylation of serine arginine-rich splicing factor (SRSF1) by SR protein kinase 1 (SRPK1) regulates alternative splicing of PD1 to generate a soluble antagonistic isoform that prevents T cell exhaustion
BackgroundRegulation of alternative splicing is a new therapeutic approach in cancer. The programmed cell death receptor 1 (PD-1) is an...
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Alternative splicing of latrophilin-3 controls synapse formation
The assembly and specification of synapses in the brain is incompletely understood
1 –3 . Latrophilin-3 (encoded by Adgrl3 , also known as Lphn3 )—a...
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Alternative Splicing and Cancer
Alternative splicing is a key process of post-transcriptional gene regulation that provides transcriptome and proteome diversity by allowing the...
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Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer
BackgroundAlternative RNA splicing is widely dysregulated in cancers including lung adenocarcinoma, where aberrant splicing events are frequently...
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Alternative splicing in prostate cancer progression and therapeutic resistance
Prostate cancer (CaP) remains the second leading cause of cancer deaths in western men. CaP mortality results from diverse molecular mechanisms that...
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Alternative splicing controls teneurin-3 compact dimer formation for neuronal recognition
Neuronal network formation is facilitated by recognition between synaptic cell adhesion molecules at the cell surface. Alternative splicing of cell...
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Determination of Differential Alternative Splicing Under Stress Conditions
Alternative splicing (AS) is an important mechanism contributing to stress-induced regulation of gene expression and proteome diversity. Massive...
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Splicing complexity as a pivotal feature of alternative exons in mammalian species
BackgroundAs a significant process of post-transcriptional gene expression regulation in eukaryotic cells, alternative splicing (AS) of exons greatly...
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Combining genetic constraint with predictions of alternative splicing to prioritize deleterious splicing in rare disease studies
BackgroundDespite numerous molecular and computational advances, roughly half of patients with a rare disease remain undiagnosed after exome or...
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Map** alternative splicing events in colorectal cancer
Although aberrant splicing events of genes are closely related to the development and progression of colorectal cancer (CRC), the map** of abnormal...
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The role of alternative pre-mRNA splicing in cancer progression
Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the...
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Alternative splicing as a source of phenotypic diversity
A major goal of evolutionary genetics is to understand the genetic processes that give rise to phenotypic diversity in multicellular organisms....
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Benchmarking splice variant prediction algorithms using massively parallel splicing assays
BackgroundVariants that disrupt mRNA splicing account for a sizable fraction of the pathogenic burden in many genetic disorders, but identifying...
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Biological relevance of alternative splicing in hematologic malignancies
Alternative splicing (AS) is a strictly regulated process that generates multiple mRNA variants from a single gene, thus contributing to proteome...
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Alternative splicing in lung influences COVID-19 severity and respiratory diseases
Alternative splicing generates functional diversity in isoforms, impacting immune response to infection. Here, we evaluate the causal role of...
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The role of alternative splicing in lung cancer
Aberrant alternative splicing (AS) events are frequently observed in lung cancer, which can be attributed to aberrant gene AS, alterations in...
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Gene expression and alternative splicing contribute to adaptive divergence of ecotypes
Regulation of gene expression is a critical link between genotype and phenotype explaining substantial heritable variation within species. However,...
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SpliceVault predicts the precise nature of variant-associated mis-splicing
Even for essential splice-site variants that are almost guaranteed to alter mRNA splicing, no current method can reliably predict whether...
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Alternative splicing and environmental adaptation in wild house mice
A major goal of evolutionary genetics is to understand the genetic and molecular mechanisms underlying adaptation. Previous work has established that...
