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Agathisflavone Modifies Microglial Activation State and Myelination in Organotypic Cerebellar Slices Culture
AbstractOligodendrocytes produce the myelin that is critical for rapid neuronal transmission in the central nervous system (CNS). Disruption of...
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The Flavonoid Agathisflavone from Poincianella pyramidalis Prevents Aminochrome Neurotoxicity
Flavonoids have been suggested to protect dopaminergic neurons in Parkinson’s disease based on studies that used exogenous neurotoxins. In this...
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Agathisflavone modulates astrocytic responses and increases the population of neurons in an in vitro model of traumatic brain injury
Traumatic brain injury (TBI) is a critical health problem worldwide, with a high incidence rate and potentially severe long-term consequences....
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Chemical composition and anti-Mayaro virus activity of Schinus terebinthifolius fruits
Brazilian traditional medicine has explored the antiviral properties of many plant extracts, including those from the Brazilian pepper tree, Schinus...
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Phytochemicals and Nutraceuticals Targeting SARS-CoV-2: An In Silico Analysis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a global pandemic in the past years and is still a global disaster. Some...
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Cytotoxicity and Antioxidant Activity Evaluation of Endemic Variety of the Western Ghats Garcinia gummi-gutta var papilla and Garcinia xanthochymus
Nowadays, there is a rapid increase in cancer incidence around the world. Hence, there is an urgent need for more efficient natural medicine...
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In vitro antioxidant properties of the biflavonoid agathisflavone
PurposeFree radicals are considered as the causative agents of a variety of acute and chronic pathologies. Natural antioxidants have drawn attention...
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Flavonoids as Potential Therapeutics Against Neurodegenerative Disorders: Unlocking the Prospects
Neurodegeneration, the decline of nerve cells in the brain, is a common feature of neurodegenerative disorders (NDDs). Oxidative stress, a key factor...
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Unveiling Nature’s Arsenal: Natural Sources for Drug Discovery in Alzheimer’s Disease
Alzheimer’s disease (AD) imposes a significant global healthcare challenge, as it currently lacks a definitive cure. This devastating condition...
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Influenza A Virus Neuraminidase Inhibitors
Depending on the strain, influenza A virus causes animal, zoonotic, pandemic, or seasonal influenza with varying degrees of severity. Two surface...
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Multiple spectroscopic fingerprinting platforms for rapid characterization of α-glucosidase inhibitors and antioxidants from some commonly consumed Indonesian vegetables and spices
Indonesia has one of the most significant biodiversity in the world. Many edible plants have served as the sources of bioactive compounds such as...
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Therapeutic and Prophylactic Effects of Plant Derivatives Against SARS CoV-2
According to World Health Organization, the crucial health risk was caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and was...
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West African medicinal plants and their constituent compounds as treatments for viral infections, including SARS-CoV-2/COVID-19
ObjectivesThe recent emergence of the COVID-19 pandemic (caused by SARS-CoV-2) and the experience of its unprecedented alarming toll on humanity have...
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African Traditional Medicine and Potential Role for Mental Health
The people of Africa face considerable mental health challenges that are linked to civil wars, unemployment, poverty, and the burden of infectious...
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Effects of Phytochemicals on Type 2 Diabetes via MicroRNAs
Purpose of ReviewType 2 diabetes, characterized by inadequate insulin secretion and resistance, is increasingly prevalent. To effectively manage type...
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Computational assessment of select antiviral phytochemicals as potential SARS-Cov-2 main protease inhibitors: molecular dynamics guided ensemble docking and extended molecular dynamics
Covid-19 caused by novel coronavirus, 2019-nCoV or SARS-CoV-2 has become most severe pandemic of this century. No specific therapies are available to...
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Chemical composition, biological activities and traditional uses of plants from the segregated genus Caesalpinia sensu lato
The species Caesalpinia s.l. (Leguminosae: Caesalpinioideae) are widely distributed over all continents and content a large amount of unusual...
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Agathis dammara (Lamb.) Poir. Araucariaceae
Abies dammara (Lamb.) Dum.Cours.; Agathis alba (Rumph. ex. Hassk.) Foxw.; Agathis celebica (Koord.) Warb.; Agathis hamii Meijer Drees; Agathis...
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Anticancer activity of Nigerian medicinal plants: a review
BackgroundCancer is currently the leading cause of death globally and the number of deaths from cancer is on the rise daily. Medicinal plants have...
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Hinokiflavone and Related C–O–C-Type Biflavonoids as Anti-cancer Compounds: Properties and Mechanism of Action
Biflavonoids are divided in two classes: C–C type compounds represented by the dimeric compound amentoflavone and C–O–C-type compounds typified by...
