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1. Metabolic dependencies of acute myeloid leukemia stem cells

   Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy primarily driven by an immature population of AML cells termed leukemia stem...

   **angguo Shi, Mengdie Feng, Daisuke Nakada in International Journal of Hematology

   Article 15 May 2024
   

2. TMIGD2 is an orchestrator and therapeutic target on human acute myeloid leukemia stem cells

   Acute myeloid leukemia (AML) is initiated and sustained by a hierarchy of leukemia stem cells (LSCs), and elimination of this cell population is...

   Hao Wang, R. Alejandro Sica, ... **ngxing Zang in Nature Communications

   Article Open access 02 January 2024
   

3. Stem Cell Transplant for Acute Myeloid Leukemia

   Acute myeloid leukemia (AML) is a hematological malignancy, which results from the clonal expansion of myeloblasts in the peripheral blood, bone...

   Sanjeev Kumar Sharma in Basics of Hematopoietic Stem Cell Transplant

   Chapter 2023
   

4. Low doses of IFN-γ maintain self-renewal of leukemia stem cells in acute myeloid leukemia

   Conventional therapies for acute myeloid leukemia (AML) often fail to eliminate the disease-initiating leukemia stem cell (LSC) population, leading...

   **aoling **e, Wuju Zhang, ... **aochun Bai in Oncogene

   Article 23 October 2023
   

5. Inflammatory recruitment of healthy hematopoietic stem and progenitor cells in the acute myeloid leukemia niche

   Inflammation in the bone marrow (BM) microenvironment is a constitutive component of leukemogenesis in acute myeloid leukemia (AML). Current evidence...

   Ding-Wen Chen, Jian-Meng Fan, ... Peter Kurre in Leukemia

   Article Open access 16 January 2024
   

6. Platelet is an unfavorable prognostic biomarker and associated with leukemia stem cells and immunomodulatory factors in acute myeloid leukemia

   Many clinical features, besides cytogenetic and molecular abnormalities, can affect the prognosis of the patients with acute myeloid leukemia (AML)....

   Qing Zhang, Haotian Yan, ... Zhimin Zhai in Annals of Hematology

   Article 15 July 2023
   

7. Modeling Acute Myeloid Leukemia Using StarPEG-Heparin Hydrogels

   Biomimetic semi-synthetic hydrogels formed from a combination of star-shaped poly(ethylene glycol) (starPEG) and the glycosaminoglycan, heparin,...

   P. Lewen Holloway, Akhilandeshwari Ravichandran, ... Laura J. Bray in 3D Cell Culture

   Protocol 2024
   

8. PHF6 loss reduces leukemia stem cell activity in an acute myeloid leukemia mouse model

   Acute myeloid leukemia (AML) is a malignant hematologic disease caused by gene mutations and genomic rearrangements in hematologic progenitors. The...

   Shengnan Yuan, Mingming Gao, ... Lingyu Zeng in Cancer Cell International

   Article Open access 09 February 2024
   

9. Anti-TIM3 chimeric antigen receptor-natural killer cells from engineered induced pluripotent stem cells effectively target acute myeloid leukemia cells

   Background

   Acute myeloid leukemia (AML) is a clonal malignant disorder which originates from a small number of leukemia-initiating cells or leukemic...

   Phatchanat Klaihmon, Sudjit Luanpitpong, ... Surapol Issaragrisil in Cancer Cell International

   Article Open access 27 November 2023
   

10. A Unified Approach to Predict and Understand Acute Myeloid Leukemia Diagnosis

    Acute myeloid leukemia (AML) is a rapidly progressing disease that affects myeloid cells in blood and bone marrow. These abnormal cancerous cells...

    Ashwini P. Patil, Manjunath Hiremath, Varsha Pawar in Power Engineering and Intelligent Systems

    Conference paper 2024
    

11. Emerging role of glutathione peroxidase 4 in myeloid cell lineage development and acute myeloid leukemia

    Phospholipid Hydroperoxide Gluthatione Peroxidase also called Glutathione Peroxidase 4 is one of the 25 described human selenoproteins. It plays an...

    Patrick Auberger, Cécile Favreau, ... Guillaume Robert in Cellular & Molecular Biology Letters

    Article Open access 08 July 2024
    

12. Acute Myeloid Leukemia

    in Dictionary of Toxicology

    Reference work entry 2024
    

13. A novel LGALS1-depended and immune-associated fatty acid metabolism risk model in acute myeloid leukemia stem cells

    Leukemia stem cells (LSCs) are recognized as the root cause of leukemia initiation, relapse, and drug resistance. Lipid species are highly abundant...

    Huanhuan Qin, Meixi Peng, ... Yu Hou in Cell Death & Disease

    Article Open access 05 July 2024
    

14. Bcl-2 inhibition combined with PPARα activation synergistically targets leukemic stem cell-like cells in acute myeloid leukemia

    Persistence of leukemic stem cells (LSCs) is one of the determining factors to acute myeloid leukemia (AML) treatment failure and responsible for the...

    Chendi **e, Hui Zhou, ... Jie Zha in Cell Death & Disease

    Article Open access 29 August 2023
    

15. HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia

    Acute myeloid leukemia (AML) is maintained by self-renewing leukemic stem cells (LSCs). A fundamental problem in treating AML is that conventional...

    Qianze Dong, Yan **u, ... Chen Zhao in Nature Communications

    Article Open access 16 October 2022
    

16. Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications

    The stem cells of acute myeloid leukemia (AML) are the malignancy initiating cells whose survival ultimately drives growth of these lethal diseases....

    Nathaniel A. Long, Upendarrao Golla, ... David F. Claxton in Stem Cell Reviews and Reports

    Article 20 January 2022
    

17. Acute myeloid leukemia stem cell signature gene EMP1 is not an eligible therapeutic target

    Background

    Relapse in pediatric acute myeloid leukemia (pedAML) patients is known to be associated with residual leukemic stem cells (LSC). We have...

    Laurens Van Camp, Barbara Depreter, ... Barbara De Moerloose in Pediatric Research

    Article 15 June 2024
    

18. The genesis and evolution of acute myeloid leukemia stem cells in the microenvironment: From biology to therapeutic targeting

    Acute myeloid leukemia (AML) is a hematological malignancy characterized by cytogenetic and genomic alterations. Up to now, combination chemotherapy...

    Yongfeng Chen, **g Li, ... Zhenyou Zou in Cell Death Discovery

    Article Open access 26 September 2022
    

19. Maintenance Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia

    Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has significantly improved the outcome of patients with acute myeloid leukemia (AML)....

    Yong-**an Hu, Hong-Hu Zhu in Pathogenesis and Treatment of Leukemia

    Chapter 2023
    

20. Deletion of Mettl3 in mesenchymal stem cells promotes acute myeloid leukemia resistance to chemotherapy

    Acute myeloid leukemia (AML) cell survival and chemoresistance are influenced by the existence of bone marrow mesenchymal stem cells (BMMSCs);...

    **nai Liao, Danni Cai, ... Huifang Huang in Cell Death & Disease

    Article Open access 05 December 2023