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Dimeric ACE2-FC Is Equivalent to Monomeric ACE2 in the Surrogate Virus Neutralization Test
AbstractAngiotensin-converting enzyme 2 (ACE2) is the main cellular receptor for the dangerous sarbecoviruses SARS-CoV and SARS-CoV-2. Its...
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Spike-and-ACE2 Binding with 100 Drugs
Durdagi (All atom 500-nano seconds molecular dynamics simulations of SARS-CoV-2 spike receptor-binding domain bound with ACE2 (Version 2) [Data set]....
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Human ACE2 Ectodomain Binding with 78 Drugs
Shaw et al. (2020) selected 5152 drug molecules from the FDA drug library and found that during 2...
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SARS-CoV-2S-Protein–Ace2 Binding Analysis Using Surface Plasmon Resonance
Surface plasmon resonance (SPR) allows for the label-free determination of the binding affinity and rate constants of bimolecular interactions. Here,...
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Effect of age on human ACE2 and ACE2-expressing alveolar type II cells levels
BackgroundAngiotensin-converting enzyme 2 (ACE2) is the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes...
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Determinants of species-specific utilization of ACE2 by human and animal coronaviruses
Utilization of human ACE2 allowed several bat coronaviruses (CoVs), including the causative agent of COVID-19, to infect humans directly or via...
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Efficient Expression in the Prokaryotic Host System, Purification and Structural Analyses of the Recombinant Human ACE2 Catalytic Subunit as a Hybrid Protein with the B Subunit of Cholera Toxin (CTB-ACE2)
Angiotensin-converting enzyme 2 (ACE2) has a specific interaction with the coronavirus spike protein, enabling its entry into human cells. This...
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A cell-based assay for rapid assessment of ACE2 catalytic function
Angiotensin-converting enzyme II (ACE2) is a monocarboxypeptidase expressed throughout multiple tissues and its catalysis of bioactive peptides...
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ACE2, ACE, DPPIV, PREP and CAT L enzymatic activities in COVID-19: imbalance of ACE2/ACE ratio and potential RAAS dysregulation in severe cases
Objective and designCirculating enzymatic activity and RAAS regulation in severe cases of COVID-19 remains unclear, therefore we measured the serum...
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ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway
The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is...
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CT-based Radiogenomics Framework for COVID-19 Using ACE2 Imaging Representations
Coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 which enters the body via the angiotensin-converting...
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Autoantibodies to ACE2 and immune molecules are associated with COVID-19 disease severity
BackgroundIncreased inflammation caused by SARS-CoV-2 infection can lead to severe coronavirus disease 2019 (COVID-19) and long-term disease...
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ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification
Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-angiotensin system, provides protection against several chronic diseases....
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Human ACE2, Human IL6, Human IL6R, and Human nAChRs
SARS-CoV-2, the virus causing the COVID-19 global pandemic, encodes for a trimeric spike glycoprotein that contains a receptor-binding domain (RBD)...
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Is the anti-aging effect of ACE2 due to its role in the renin-angiotensin system?—Findings from a comparison of the aging phenotypes of ACE2-deficient, Tsukuba hypertensive, and Mas-deficient mice—
Angiotensin converting enzyme 2 (ACE2) functions as an enzyme that produces angiotensin 1-7 (A1-7) from angiotensin II (AII) in the renin-angiotensin...
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Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting SARS-CoV-2
The angiotensin-converting enzyme 2 (ACE2) is a viral receptor used by sarbecoviruses to infect cells. Fusion proteins comprising extracellular ACE2...
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FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection
The angiotensin-converting enzyme 2 (ACE2) is a primary cell surface viral binding receptor for SARS-CoV-2, so finding new regulatory molecules to...
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ACE2 inhibits proliferation of smooth muscle cell through AT1R and its downstream signaling pathway
To investigate the effect of the angiotensin converting enzyme 2 (ACE2) on AT1R expression, ERK1/2 and STAT3 protein phosphorylation in rat vascular...
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Broad host tropism of ACE2-using MERS-related coronaviruses and determinants restricting viral recognition
Recently, two Middle East respiratory syndrome coronavirus (MERS-CoV) closely related to bat merbecoviruses, NeoCoV and PDF-2180, were discovered to...
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ACE2-dependent and -independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection
Excessive inflammation is the primary cause of mortality in patients with severe COVID-19, yet the underlying mechanisms remain poorly understood....
