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Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex
BackgroundThe retinal pigment epithelium (RPE), a layer of pigmented cells that lies between the neurosensory retina and the underlying choroid,...
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Epithelial membrane protein 2 (EMP2) regulates hypoxia-induced angiogenesis in the adult retinal pigment epithelial cell lines
Pathologic retinal neovascularization is a potentially blinding consequence seen in many common diseases including diabetic retinopathy, retinopathy...
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Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions
In addition to hypoxia, inflammation is capable of inducing vascular endothelial growth factor (VEGF) expression in human retinal pigment epithelial...
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CYTOR-NFAT1 feedback loop regulates epithelial-mesenchymal transition of retinal pigment epithelial cells
Epithelial mesenchymal transition (EMT) occurring in retinal pigment epithelial cells (RPE) is a crucial mechanism that contributes to the...
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Laser Treatment in Rhegmatogenous Retinal Detachment
Retinal laser is an essential tool in the treatment and prevention of retinal detachment (RD). Laser retinopexy to fuse the retina to the underlying...
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Application of Human Stem Cell Derived Retinal Organoids in the Exploration of the Mechanisms of Early Retinal Development
The intricate neural circuit of retina extracts salient features of the natural world and forms bioelectric impulse as the origin of vision. The...
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Neurosensory Retinal Lesions
It is easier to diagnose lesions of the neurosensory retina if these are considered separately from those of the retinal pigment epithelium....
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Pro-inflammatory activation changes intracellular transport of bevacizumab in the retinal pigment epithelium in vitro
PurposeBevacizumab is taken up and transported through the retinal pigment epithelium. Inflammatory signaling may influence this interaction. In the...
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Epigenetic mechanism of SET7/9-mediated histone methylation modification in high glucose-induced ferroptosis in retinal pigment epithelial cells
Ferroptosis of the retinal pigment epithelial (RPE) cells leads to retinal neuron injury and even visual loss. Our study aims to investigate the role...
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Retinal detachment
Retinal detachment (RD) occurs when the neurosensory retina, the neurovascular tissue responsible for phototransduction, is separated from the...
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Effects of galectin-3 protein on UVA-induced damage in retinal pigment epithelial cells
Several inflammatory molecules have been suggested as biomarkers of age-related macular degeneration (AMD). Galectin-3 (Gal-3), which has been shown...
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Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
BackgroundAgeing is the principal risk factor for retinal degenerative diseases, which are the commonest cause of blindness in the developed...
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Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy
The retinal pigment epithelium (RPE) plays an important role in the development of diabetic retinopathy (DR), a leading cause of blindness worldwide....
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Oleuropein Protects Human Retinal Pigment Epithelium Cells from IL-1β–Induced Inflammation by Blocking MAPK/NF-κB Signaling Pathways
Proinflammatory mediators such as interleukin (IL)-1β cause retinal pigment epithelium (RPE) inflammation, which is related to visual deterioration,...
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Prolonged Exposure to High Glucose Induces Premature Senescence Through Oxidative Stress and Autophagy in Retinal Pigment Epithelial Cells
Chronic hyperglycemia involves persistent high-glucose exposure and correlates with retinal degeneration. It causes various diseases, including...
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Autofluorescence Imaging to Evaluate Retinal Disease Progression in Rodent
Fundus autofluorescence (FAF) imaging is a noninvasive retinal imaging methodology that allows map** of lipofuscin distribution in the retinal...
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Subthreshold laser treatment in retinal diseases: a mini review
PurposeTo summarize the mechanism and the clinical applications of subthreshold laser (STL) in retinal practice. Subthreshold or “non-destructive”...
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Analysis of RNA Interference Targeted Against Human Antigen R (HuR) to Reduce Vascular Endothelial Growth Factor (VEGF) Protein Expression in Human Retinal Pigment Epithelial Cells
VEGF-A or vascular endothelial growth factor-A is an important factor in enabling neovascularization and angiogenesis. VEGF-A is regulated...
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Thickness of retinal pigment epithelium–Bruch’s membrane complex in adult Chinese using optical coherence tomography
PurposeTo study thickness of RPE–BM complex in adult Chinese subjects and its correlation with systemic and ocular biometric parameters.
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Prevalence of and factors associated with dilated choroidal vessels beneath the retinal pigment epithelium among the Japanese
Pachyvessels are pathologically dilated large choroidal vessels and are associated with the pathogenesis of several pachychoroid-related disorders,...
