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MCT4-driven CAF-mediated metabolic reprogramming in breast cancer microenvironment is a vulnerability targetable by miR-425-5p
Multiple oncogenic alterations contribute to breast cancer development. Metabolic reprogramming, deeply contributing to tumor microenvironment (TME)...
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Stem Cell-derived Extracellular Vesicles: A Promising Nano Delivery Platform to the Brain?
A very important cause of the frustration with drug therapy for central nervous system (CNS) diseases is the failure of drug delivery. The...
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RNA Therapy in Bone Diseases
Bones are constantly modeling and remodeling in a stable internal environment. When the homeostasis is damaged with age growth and pathological...
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Identifying Biomarkers for Osteogenic Potency Assay Development
There has been extensive exploration of how cells may serve as advanced therapy medicinal products to treat skeletal pathologies. Osteoblast...
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Gene Therapy and Cardiovascular Diseases
Cardiovascular diseases (CVDs) are the leading causes of death globally and urgently require new novel therapeutic strategies. Gene therapy is the...
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Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice
MicroRNAs (miRs) are small non-coding RNAs that post-transcriptionally control gene expression. Inhibition of miRs by antisense RNAs (antimiRs) might...
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Nanogel Synthesis by Irradiation of Aqueous Polymer Solutions
Nanogels/microgels are intramolecularly crosslinked particles with submicron diameters that can swell in a suitable solvent due to their...
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CD204-positive M2-like tumor-associated macrophages increase migration of gastric cancer cells by upregulating miR-210 to reduce NTN4 expression
BackgroundTumor-associated macrophages (TAMs) are the predominant immune cells in the tumor microenvironment and portend poor prognosis. However, the...
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Opposite effects of miR-155 in the initial and later stages of lipopolysaccharide (LPS)-induced inflammatory response
Although microRNA-155 (miR-155) is considered a pro-inflammatory mediator, cumulative evidence indicates that it also has anti-inflammatory effects...
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DNA–RNA Heteroduplex Oligonucleotide for Highly Efficient Gene Silencing
Heteroduplex oligonucleotides (HDOs)Heteroduplex oligonucleotides (HDOs) were a novel type of nucleic acid drugs based on an antisenseAntisense...
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The therapeutic potential of stem cell-derived exosomes in the ulcerative colitis and colorectal cancer
BackgroundMesenchymal stem cells (MSCs) therapy is a novel treatment strategy for cancer and a wide range of diseases with an excessive immune...
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Mesenchymal stem cells and dental implant osseointegration during aging: from mechanisms to therapy
Dental implants are widely used to replace missing teeth, providing patients with unparalleled levels of effectiveness, convenience, and...
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The Significant Role of microRNAs in Gliomas Angiogenesis: A Particular Focus on Molecular Mechanisms and Opportunities for Clinical Application
MicroRNAs (miRNAs) are non-coding RNAs with only 20–22 nucleic acids that inhibit gene transcription and translation by binding to mRNA. MiRNAs have...
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Small RNAs, spermatogenesis, and male infertility: a decade of retrospect
Small non-coding RNAs (sncRNAs), being the top regulators of gene expression, have been thoroughly studied in various biological systems, including...
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Methods Used to Make Lipid Nanoparticles to Deliver LNA Gapmers Against lncRNAs into Acute Myeloid Leukemia (AML) Blasts
Develo** strategies to target lncRNAs are needed. In this chapter, we describe in detail a method to deliver antisense oligonucleotides into acute...
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Unique Features of the Human Sinoatrial Node Structure, Function, and Arrhythmias: Mechanistic Insights from Integrated 3D Map** Approaches
The sinoatrial node (SAN) is the primary pacemaker in mammalian hearts, which generates intrinsic electrical activation to maintain synchronous and...
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Host miRNA and immune cell interactions: relevance in nano-therapeutics for human health
Around 2200 miRNA (microRNA) genes were found in the human genome. miRNAs are arranged in clusters within the genome and share the same...
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The novel importance of miR-143 in obesity regulation
Obesity and substantially increased risk of metabolic diseases have become a global epidemic. microRNAs have attracted a great deal of attention as a...
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EVs vs. EVs: MSCs and Tregs as a source of invisible possibilities
Extracellular vesicles (EVs) are produced by various cells and exist in most biological fluids. They play an important role in cell–cell signaling,...
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Aptamer-Based Drug Delivery Systems
Recently, aptamer-based drug delivery systems (DDSs) emerged as attractive platforms for precise medicine by targeting to disease cells and reducing...