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Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
The chemokine receptor CCR5 plays a vital role in immune surveillance and inflammation. However, molecular details that govern its endogenous...
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Premature commitment to uncertain decisions during human NMDA receptor hypofunction
Making accurate decisions based on unreliable sensory evidence requires cognitive inference. Dysfunction of n-methyl-d-aspartate (NMDA) receptors...
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Candidate 3-benzazepine-1-ol type GluN2B receptor radioligands (11C-NR2B-Me enantiomers) have high binding in cerebellum but not to σ1 receptors
IntroductionWe recently reported 11 C-NR2B-SMe ([ S - methyl - 11 C]( R,S )-7-thiomethoxy-3-(4-(4-methyl-phenyl)butyl)-2,3,4,5-tetrahydro-1 H -benzo[ d ]azepin-1-...
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Behavioral characteristics of dopamine D5 receptor knockout mice
Major psychiatric disorders such as attention-deficit/hyperactivity disorder and schizophrenia are often accompanied by elevated impulsivity....
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Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies
G-protein-coupled receptors (GPCRs) receive signals from ligands with different efficacies, and transduce to heterotrimeric G-proteins to generate...
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The interplay between membrane viscosity and ligand-binding receptor kinetics in lipid bilayers
Plasma membranes appear as deformable systems wherein molecules are free to move and diffuse giving rise to condensed microdomains (composed of...
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Modelling lipid rafts formation through chemo-mechanical interplay triggered by receptor–ligand binding
Cell membranes, mediator of many biological mechanisms from adhesion and metabolism up to mutation and infection, are highly dynamic and...
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Sigma factor binding protein 1 (CsSIB1) is a putative candidate of the major-effect QTL dm5.3 for downy mildew resistance in cucumber (Cucumis sativus)
Key messageThe dm5.3 major-effect QTL in cucumber encodes a homolog of Arabidopsis sigma factor binding protein 1 (CsSIB1). CsSIB1 positively...
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Receptor model-based approach to estimate urban road dust pollution by heavy metal(loid)s exposed to desert dust storms in a rapid-growing city of Iran
To assess the application of a receptor model on the identification of urban road dust pollution and associated human health risks by six heavy...
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Control of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43
The type-1 cannabinoid receptor (CB 1 R) is widely expressed in excitatory and inhibitory nerve terminals, and by suppressing neurotransmitter release,...
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A novel nuclear receptor subfamily enlightens the origin of heterodimerization
BackgroundNuclear receptors are transcription factors of central importance in human biology and associated diseases. Much of the knowledge related...
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Stochastic model of ERK-mediated progesterone receptor translocation, clustering and transcriptional activity
Progesterone receptor (PR) transcriptional activity is a key factor in the differentiation of the uterine endometrium. By consequence, progestin has...
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Applications of radiomics-based analysis pipeline for predicting epidermal growth factor receptor mutation status
BackgroundThis study aimed to develop a pipeline for selecting the best feature engineering-based radiomic path to predict epidermal growth factor...
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Stability improvement of polyaniline nanocomposite immunosensor for early detection of insulin receptor antibody as biomarker of type 2 diabetes
Polyaniline nanocomposite with controllable properties was used to design and fabricate a novel electrochemical immunosensor for the early detection...
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A facile on-site colorimetric solid-state sensing of Cu2+ using chelating receptor immobilized porous polymer monolith material
This work discusses the fabrication and applicability of a cost-effective and ultra-sensitive solid-state optical sensor for quantifying Cu 2+ . The...
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SARS CoV-2 spike protein variants exploit DC-SIGN/DC-SIGNR receptor for evolution and severity: an in-silico insight
The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is related with the COVID-19 pandemic. Recent spike protein variations have had an...
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Prediction of Virus-Receptor Interactions Based on Similarity and Matrix Completion
Viral infectious diseases are threatening human health and global security by rapid transmission and severe fatalities. The receptor-binding is the...
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Autophagy receptor NDP52 alters DNA conformation to modulate RNA polymerase II transcription
NDP52 is an autophagy receptor involved in the recognition and degradation of invading pathogens and damaged organelles. Although NDP52 was first...
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Design, synthesis and antiproliferative activity of new amine, amino acid and dipeptide-coupled benzamides as potential sigma-1 receptor
N -Alkyl-2-(substitutedbenzamido) benzamides and methyl 2-(2-(substitutedbenzamido) benzamido) alkanoates were prepared by either the reaction of...
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Fluorescence anisotropy cytosensing of folate receptor positive tumor cells using 3D polyurethane-GO-foams modified with folic acid: molecular dynamics and in vitro studies
Integrated polyurethane (PU)–based foams modified with PEGylated graphene oxide and folic acid (PU@GO-PEG-FA) were developed with the goal of...
