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Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex
Abnormalities in neocortical and synaptic development are linked to neurodevelopmental disorders. However, the molecular and cellular mechanisms...
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Epilepsy and epileptiform activity in late-onset Alzheimer disease: clinical and pathophysiological advances, gaps and conundrums
A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and epilepsy. Late-onset epilepsy and epileptiform activity can...
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Positron Emission Tomography (PET) Imaging Biomarkers in Huntington’s Disease
Huntington’s disease (HD) is a rare, autosomal, and dominantly inherited neurodegenerative disease characterized by aggregation of mutated Huntingtin...
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Levetiracetam treatment leads to functional recovery after thoracic or cervical injuries of the spinal cord
Spinal cord injury (SCI) leads to dramatic impairments of motor, sensory, and autonomic functions of affected individuals. Following the primary...
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The synaptic hypothesis of schizophrenia version III: a master mechanism
The synaptic hypothesis of schizophrenia has been highly influential. However, new approaches mean there has been a step-change in the evidence...
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Preclinical PET Studies of [11C]UCB-J Binding in Minipig Brain
PurposeLoss of neuronal synapse function is associated with a number of brain disorders. The [ 11 C]UCB-J positron emission tomography (PET) tracer...
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Antiseizure Medications
Epilepsy and status epilepticus (SE) are both common neurologic disease states encountered in any neurocritical care unit and require aggressive...
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Development of fibrotic gene signature and construction of a prognostic model in melanoma
PurposeSkin cutaneous melanoma (SKCM) is a malignant tumor responsible for over 75% of skin cancer deaths, the relationship between fibrosis and...
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Age-dependent anticonvulsant actions of perampanel and brivaracetam in the methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) model of seizures in develo** rats
BackgroundThe antiseizure drugs commonly used as first- and second-line treatments for neonatal seizures display poor efficacy. Thus, drug mechanisms...
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Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer’s Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway
Lycium barbarum polysaccharide (LBP) have a certain curative effect on hypoglycemic and neuroprotective effects, but the specific mechanism is...
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The proteomic architecture of schizophrenia iPSC-derived cerebral organoids reveals alterations in GWAS and neuronal development factors
Schizophrenia (Scz) is a brain disorder that has a typical onset in early adulthood but otherwise maintains unknown disease origins. Unfortunately,...
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The Functional State of Glutamate- and GABA-Ergic Neurons in the Inferior Colliculi of Krushinsky–Molodkina Rats at Early Stages of Epileptogenesis
AbstractDisturbances in the neurotransmitter systems associated with the development of temporal lobe epilepsy (TLE) have been well-studied in...
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Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer’s disease
The associations of synaptic loss with amyloid-β (Aβ) and tau pathology measured by positron emission tomography (PET) and plasma analysis in...
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Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons
Autophagy is a conserved, catabolic process essential for maintaining cellular homeostasis. Malfunctional autophagy contributes to neurodevelopmental...
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Tetanus toxin and botulinum neurotoxin–derived fusion molecules are effective bivalent vaccines
AbstractTetanus toxin (TeNT) and botulinum neurotoxins (BoNTs) are neuroprotein toxins, with the latter being the most toxic known protein. They are...
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Substance use and spine density: a systematic review and meta-analysis of preclinical studies
The elucidation of synaptic density changes provides valuable insights into the underlying brain mechanisms of substance use. In preclinical studies,...
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Preliminary evidence for preserved synaptic density in late-life depression
Late-life depression has been consistently associated with lower gray matter volume, the origin of which remains largely unexplained. Recent in-vivo...
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Levetiracetam (LEV)
Das Kapitel zeigt tabellarisch das Kurzprofil des Medikaments Levetiracetam (LEV).