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Rapamycin can alleviate the submandibular gland pathology of Sjögren's syndrome by limiting the activation of cGAS–STING signaling pathway
BackgroundSjögren’s Syndrome (SS) is also known as autoimmune exocrine gland disease. Previous studies have confirmed that adaptive immunity plays an...
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An integral role of mitochondrial function in the pathophysiology of preeclampsia
Preeclampsia (PE) is associated with high maternal and perinatal morbidity and mortality. The development of effective treatment strategies remains a...
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Simplifying synthesis of the expanding glioblastoma literature: a topic modeling approach
PurposeOur study aims to discover the leading topics within glioblastoma (GB) research, and to examine if these topics have “hot” or “cold” trends....
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The multiple links between actin and mitochondria
Actin plays many well-known roles in cells, and understanding any specific role is often confounded by the overlap of multiple actin-based structures...
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Respiratory Function of Mitochondria in Patients with Coronary Heart Disease with Implantable Cardioverter-Defibrillator
We studied the respiratory activity of mitochondria in peripheral blood leukocytes from 36 patients with coronary heart disease (CHD) and a history...
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How to Build a Neuron
The neuron is simply another term for a brain cell. Cells, as we know, are the teeniest components of all living animals, at least in terms of a...
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Deciphering molecular regulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) signalling networks in Oryza genus amid environmental stress
The Oryza genus, containing Oryza sativa L., is quintessential to sustain global food security. This genus has a lot of sophisticated molecular...
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The Protective Mechanism of TFAM on Mitochondrial DNA and its Role in Neurodegenerative Diseases
Mitochondrial transcription factor A (TFAM) is a mitochondrial protein encoded by nuclear genes and transported from the cytoplasm to the...
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The interplay between androgens and the immune response in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a metabolic-reproductive-endocrine disorder that, while having a genetic component, is known to have a complex...
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Physiological Impact of Reactive Oxygen Species on Leaf
In this chapter, we summarized our current understanding of the various ROS types, their production mechanisms, and their physiological effects on...
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Co-expression network analysis of protein phosphatase 2A (PP2A) genes with stress-responsive genes in Arabidopsis thaliana reveals 13 key regulators
Abiotic and biotic stresses adversely affect plant growth and development and eventually result in less yield and threaten food security worldwide....
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Energy deprivation-induced autophagy and aggrephagy: insights from yeast and mammals
Autophagy plays a crucial role in maintaining cellular homeostasis in response to various stimuli. Compared to research on nutrient...
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Immunohistochemical Analysis of Mitochondrial Dynamics in Different Zones of the Hippocampus during Experimental Modeling of Alzheimer’s Disease
We performed a comparative assessment of the immunohistochemical distribution of markers of mitochondrial fission (Drp-1), mitochondrial fusion...
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Protein Disulfide Isomerase A2 Is Correlated with Immune Infiltrates and Is a Novel Prognostic Biomarker in Glioma Patients
ObjectiveProtein disulfide isomerase A2 (PDIA2), a member of the protein disulfide isomerase family, plays a key role in the folding of nascent...
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Pantothenate kinase 2 interacts with PINK1 to regulate mitochondrial quality control via acetyl-CoA metabolism
Human neurodegenerative disorders often exhibit similar pathologies, suggesting a shared aetiology. Key pathological features of Parkinson’s disease...
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Hispidulin: a promising anticancer agent and mechanistic breakthrough for targeted cancer therapy
Cancer is a complex disease characterized by dysregulated cell growth and division, posing significant challenges for effective treatment....
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Diversity and complexity of cell death: a historical review
Death is the inevitable fate of all living organisms, whether at the individual or cellular level. For a long time, cell death was believed to be an...
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Cell and Storage
Acute and chronic exercise training is effective in promoting health and preventing or improving many diseases. Exercise training leads to many...