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Long noncoding RNA H19 regulates the therapeutic efficacy of mesenchymal stem cells in rats with severe acute pancreatitis by sponging miR-138-5p and miR-141-3p
BackgroundPatients with severe acute pancreatitis (SAP), which is characterized by high morbidity and mortality, account for an increasing medical...
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Effects of H19/SAHH/DNMT1 on the oxidative DNA damage related to benzo[a]pyrene exposure
The mechanisms that long noncoding RNA (lncRNA) H19 binding to S-adenosylhomocysteine hydrolase (SAHH) interacted with DNA methyltransferase 1...
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Long noncoding RNAs as regulators of pediatric acute myeloid leukemia
Long noncoding RNAs (lncRNAs) are increasingly emerging as regulators across human development and disease, and many have been described in the...
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The role of noncoding RNAs in metabolic reprogramming of cancer cells
Metabolic reprogramming is a well-known feature of cancer that allows malignant cells to alter metabolic reactions and nutrient uptake, thereby...
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Long Intergenic Noncoding RNAs Affect Biological Pathways Underlying Autoimmune and Neurodegenerative Disorders
Long intergenic noncoding RNAs (lincRNAs) are a class of independently transcribed molecules longer than 200 nucleotides that do not overlap known...
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Function of Long Noncoding RNAs in Glioma Progression and Treatment Based on the Wnt/β-Catenin and PI3K/AKT Signaling Pathways
Gliomas are a deadly primary malignant tumor of the central nervous system, with glioblastoma (GBM) representing the most aggressive type. The...
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Clinical Utility of Noncoding RNAs as Systemic Biomarkers in Animal Models
Noncoding RNAs are the RNAs that do not encode for proteins, yet play a vital role in various cellular processes. Compelling cancer research evidence... -
Diagnostic, prognostic and therapeutic potential of long noncoding RNAs in cancer
Long noncoding RNAs (lncRNAs) are longer than 200 nucleotides in length and undergo splicing, cap**, polyadenylation, and editing just like mRNA....
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Altered expression of long noncoding RNA MEG3 in the offspring of gestational diabetes mellitus induces impaired glucose tolerance in adulthood
AimGestational diabetes mellitus (GDM) affects a significant number of women worldwide and has been associated with lifelong health consequences for...
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Detection and analysis of long noncoding RNA expression profiles related to epithelial–mesenchymal transition in keloids
BackgroundThe role of epithelial-mesenchymal transition (EMT) in the pathogenesis of keloids is currently raising increasing attention. Long...
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Noncoding RNA-mediated molecular bases of chemotherapy resistance in hepatocellular carcinoma
Despite the significant progress in decreasing the occurrence and mortality of hepatocellular carcinoma (HCC), it remains a public health issue...
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Role of Curcumin in Regulating Long Noncoding RNA Expression in Cancer
Phytochemicals are various compounds produced by plants. There is growing evidence on their potential health effects. Some of these compounds are... -
A novel imatinib-upregulated long noncoding RNA plays a critical role in inhibition of tumor growth induced by Abl oncogenes
BackgroundDysregulation of long noncoding RNAs (lncRNAs) has been linked to various human cancers. Bcr-Abl oncogene that results from a reciprocal...
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Long noncoding RNA ADAMTS9-AS1 represses ferroptosis of endometrial stromal cells by regulating the miR-6516-5p/GPX4 axis in endometriosis
Endometriosis (EMs) is one of the most frequent diseases of reproductive-age women and is characterized by the growth of endometrial tissues beyond...
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The role and possible mechanism of the long noncoding RNA LINC01260 in nonalcoholic fatty liver disease
ObjectiveTo investigate the differential expression profile of lncRNAs in the nonalcoholic fatty liver disease (NAFLD) model induced by oleic acid...
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Highlighting the role of long non-coding RNA (LncRNA) in multiple myeloma (MM) pathogenesis and response to therapy
Transcripts longer than 200 nucleotides that are not translated into proteins are known as long non-coding RNAs, or lncRNAs. Now, they are becoming...
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Wnt Signaling-Related Long Noncoding RNAs: Critical Mediators of Drug Resistance in Colon Cancer
Colon cancer is the third largest cancer-related death in the world and is increasing in develo** countries. Several molecular pathways controlled... -
Long noncoding RNA CRART16 confers 5-FU resistance in colorectal cancer cells by sponging miR-193b-5p
BackgroundThe emergence of chemoresistance to 5-fluorouracil (5-FU)-based chemotherapy is the main cause of treatment failure in advanced and...
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A comprehensive understanding of hnRNP A1 role in cancer: new perspectives on binding with noncoding RNA
The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is the most abundant and ubiquitously expressed member of the heterogeneous nuclear...
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Regulation of Glial Function by Noncoding RNA in Central Nervous System Disease
Non-coding RNAs (ncRNAs) are a class of functional RNAs that play critical roles in different diseases. NcRNAs include microRNAs, long ncRNAs, and...