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Clinical Utility of Noncoding RNAs as Systemic Biomarkers in Animal Models

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Handbook of Animal Models and its Uses in Cancer Research

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Abstract

Noncoding RNAs are the RNAs that do not encode for proteins, yet play a vital role in various cellular processes. Compelling cancer research evidence has revealed the function of ncRNAs either as oncogenes or agonizing as tumor suppressors via participating in various cancer hallmarks including cell proliferation, evasion, metastasis, angiogenesis, and dissemination. Both in vitro and in vivo studies have indicated the significant role of ncRNAs as potential biomarkers for scrutinizing cancer progression, early diagnosis, relapse, or response to the therapy. The focus on animal model study promotes specific understanding of ncRNA’s role in cancer development and prognosis due to their anatomical, genetic, and physiological similarities with human subjects. Besides, the study has highlighted various genetic as well as epigenetic alterations in noncoding regions of DNA. Precisely, among various ncRNAs, the ubiquitous nature of microRNAs and long noncoding RNAs is majorly found in both physiological and pathological stages at cancer progression. However, the exact mechanism underlying ncRNAs activities is yet delusional. This chapter discusses the role of various ncRNA studies in the animal model and identifies their exact role in tumor pathogenesis. The chapter highlights the role of various ncRNAs in distinct cancer types along with their involvement in distinct cellular processes. It also discusses the therapeutic potential of ncRNAs in combatting the problem of chemoresistance and radioresistance.

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Authors and Affiliations

  1. Amity Institute of Biotechnology, Amity University, Noida, India

    Siuli Shaw, Sartaj Khurana, Ayushi Mukherjee & Sudeep Bose

  2. Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Noida, India

    Sartaj Khurana & Sudeep Bose

  3. Amity Institute of Nanotechnology, Amity University, Noida, India

    Ranu Nayak

Authors
  1. Siuli Shaw
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  2. Sartaj Khurana
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  3. Ayushi Mukherjee
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  4. Ranu Nayak
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  5. Sudeep Bose
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Corresponding authors

Correspondence to Ranu Nayak or Sudeep Bose .

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Editors and Affiliations

  1. Cancer Biology and Biotechnology Lab Faculty of Allied Health Sciences Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai, India

    Surajit Pathak

  2. Cancer Biology and Biotechnology Lab Faculty of Allied Health Sciences Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai, India

    Antara Banerjee

  3. AGENTEM (Adana Genetic Diseases Diagnosis and Treatment Center) & Medical Genetics Department of Medical Faculty, Cukurova University, Adana, Turkey

    Atil Bisgin

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Shaw, S., Khurana, S., Mukherjee, A., Nayak, R., Bose, S. (2023). Clinical Utility of Noncoding RNAs as Systemic Biomarkers in Animal Models. In: Pathak, S., Banerjee, A., Bisgin, A. (eds) Handbook of Animal Models and its Uses in Cancer Research. Springer, Singapore. https://doi.org/10.1007/978-981-19-3824-5_57

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