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Neurotrophic Natural Products
Neurotrophins (NGF, BDNF, NT3, NT4) can decrease cell death, induce differentiation, as well as sustain the structure and function of neurons, which...
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Chinmedomics: a potent tool for the evaluation of traditional Chinese medicine efficacy and identification of its active components
As an important part of medical science, Traditional Chinese Medicine (TCM) attracts much public attention due to its multi-target and multi-pathway...
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Angong Niuhuang Wan reduces hemorrhagic transformation and mortality in ischemic stroke rats with delayed thrombolysis: involvement of peroxynitrite-mediated MMP-9 activation
BackgroundHemorrhagic transformation (HT) is a common complication of delayed tissue plasminogen activator (t-PA) treatment for ischemic stroke....
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Therapeutic Role of Chinese Medicine Targeting Nrf2/HO-1 Signaling Pathway in Myocardial Ischemia/Reperfusion Injury
Acute myocardial infarction (AMI), characterized by high incidence and mortality rates, poses a significant public health threat. Reperfusion...
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Anti-coronavirus and anti-pulmonary inflammation effects of iridoids, the common component from Chinese herbal medicines for the treatment of COVID-19
The practice of Chinese herbal medicines for the treatment of COVID-19 in China played an essential role for the control of mortality rate and...
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Natural products ameliorating the adverse health effects by air particulate matter
The threats of air pollution mediated by particulate matter (PM) to human health are severe burdens to modern society. For example, PM is inhaled in...
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Geniposide Increases Unfolded Protein Response-Mediating HRD1 Expression to Accelerate APP Degradation in Primary Cortical Neurons
Altered proteostasis induced by amyloid peptide aggregation and hyperphosphorylation of tau protein, is a prominent feature of Alzheimer’s disease,...
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Genipin inhibits proliferation of gastric cancer cells by inducing ferroptosis: an integrated study of network pharmacology and bioinformatics study
Ferroptosis has been demonstrated to suppress cancer development and is targeted for cancer therapy. Genipin, an iridoid constituent in Gardeniae...
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Expression of a highly active β-glucosidase from Aspergillus niger AS3.4523 in Escherichia coli and its application in gardenia blue preparation
PurposeGardenia blue is one of the natural food additives used in East Asia for many years. Its biosynthesis relies on a key rate-limiting cellulase:...
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Deep eutectic solvents in the extraction of active compounds from Eucommia Ulmoides Oliv. leaves
Eucommia ulmoides Oliv. leaves (EULs) are a newly-develo** food feedstock in China, containing various active compounds with important biological...
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Glucagon-like peptide-1 (GLP-1) receptor agonists for headache and pain disorders: a systematic review
BackgroundGlucagon-like peptide-1 (GLP-1) plays a crucial role in metabolic disorders by enhancing insulin secretion, inhibiting glucagon release,...
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Predicting the Content of the Main Components of Gardeniae Fructus Praeparatus Based on Deep Learning
Gardeniae Fructus (GF) and its stir-fried product, Gardeniae Fructus Praeparatus (GFP), are commonly used herbal medicines in traditional Chinese...
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Bio-Specific Extraction/Receptor Fishing for Screening of Active Components in Chinese Medicines
In this chapter, the principles and processes of bio-specific extraction/receptor fishing, such as equilibrium dialysis, centrifugation, and...
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An insight into the ethnopharmacological importance of Indian subcontinent medicinal plant species of Rubiaceae family
The 611 genera and over 13,100 species that make up the vast family Rubiaceae are primarily found in tropical and warm climates. These species are...
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The impact of selected xanthophylls on oil hydrolysis by pancreatic lipase: in silico and in vitro studies
Lipase inhibition is one of the directions to control obesity. In vitro assays have confirmed the inhibitory effect of selected xanthophylls,...
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Herbal Medicines for the Treatment of Liver Cirrhosis
Liver cirrhosis is a disastrous terminal consequence of different types of chronic liver diseases (CLDs), with fibrosis serving as an initial stage...
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Traditional application and modern pharmacological research of Eucommia ulmoides Oliv.
As a Traditional Chinese Medicine, Eucommia ulmoides Oliv. has been used for the treatment of various diseases since ancient times, involving lumbar...
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TCM Substances in Neuropsychopharmacotherapy
With the unique and comprehensive understanding of human’s body and various pathological conditions, Traditional Chinese Medicine (TCM) has...
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Research progress on multiple cell death pathways of podocytes in diabetic kidney disease
Diabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical manifestations are progressive proteinuria, decreased...
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