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Role of Immune Cells in the Tumor Microenvironment
Immune cells of different lineages in the tumor microenvironment (TME) play essential roles in tumorigenesis. Some cells act against the tumor, while...
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ROS, Redox Regulation and Signaling in Cancer Cells
This chapter entitled “ROS, Redox Regulation and Signaling in Cancer Cells” initially gives description of all the major ROS with their stability...
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Role of Cancer Stem Cells in Drug Resistance
The chapter on the “Role of Cancer Stem Cells in Drug Resistance” explores the intricate mechanisms underlying the resistance of cancer stem cells...
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Mesenchymal Stem Cells, Cancer Stem Cells (CSCs), and Circulating Tumor Cells (CTCs): Roles and Combinations in Tumor Growth and Dissemination
Mesenchymal stem cells are considered the key cells in tissue regeneration after damage. MSCs play a fundamental role in cancer since they can be...
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Reactive Oxygen Species and Cancer Stem Cells: Molecular Interactions and Their Implications in Cancer
Cancer stem cells (CSCs) in a tumor bulk exhibit self-renewal capacity and contribute to tumor aggressiveness that leads to metastasis, cancer...
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Estrogen-induced immune changes within the normal mammary gland
Breast cancer (BCa) incidence increases following aberrant hormone exposure, which has been linked to direct effects on estrogen receptor (ER) + ...
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A Novel ATM Antisense Transcript ATM-AS Positively Regulates ATM Expression in Normal and Breast Cancer Cells
ObjectiveThe ataxia telangiectasia mutated ( ATM ) gene is a master regulator in cellular DNA damage response. The dysregulation of ATM expression is...
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Cancer Stem Cells and Their Therapeutic Usage
Cancer stem cells (CSC) have unique characteristics which include self-renewal, multi-directional differentiation capacity, quiescence/dormancy, and...
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Potential functions and therapeutic implications of glioma-resident mesenchymal stem cells
Mesenchymal stem cells (MSCs) are emerging crucial regulators in the tumor microenvironment (TME), which contributes to tumor progression and...
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Immune System Influence on Hematopoietic Stem Cells and Leukemia Development
Hematopoietic stem cells (HSCs) are the source for all blood cells, including immune cells, and they interact dynamically with the immune system....
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The Role of Gamma Delta T Cells in Cancer
γδ T cells are a group of T lymphocytes known as nonconventional T cells. They are able to interact with a diverse range of antigens independent from...
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Role of C-Type Lectins in the Tumor Microenvironment
C-type lectin receptors (CLRs) represent a broad and diversified family of pattern recognition receptors (PRRs) that are mainly expressed on the...
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Reprogrammed Schwann Cells in Cancer
Nerves and their most abundant cell type, Schwann cells (SCs), are novel and important players in the tumor microenvironment. SCs constitute a family...
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Selection and Maintenance of Cultured Cells
In the exploration of basic scientific and translational research concerns, cell culture is a very versatile technique. The uniformity of cell lines...
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C1s targeting antibodies inhibit the growth of cutaneous squamous carcinoma cells
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The incidence of cSCC is increasing globally and the prognosis of...
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Cancer Stem Cells (CSCs) in Tumor Ecosystem
In cancer, cancer stem cells (CSCs) is a unique cell population that could acquire the stemness ability of a stem cell that enable them to...
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Proliferative Activity of Ehrlich Carcinoma Cells After Use of Nanocomplexes
Investigation of functional state of tumor cells, peculiarities of the pathology development, and sensitivity of tumor cells to the therapeutic...
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Amino Acids Transport as an Index of Cancer Stem Cells Dysregulation
The appearance, proliferation, metastasis, and even resistance to chemotherapy depend on the molecular identity of the so-called Cancer Stem Cells...
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EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells
BackgroundChromosomal inversions involving anaplastic lymphoma kinase ( ALK ) and echinoderm microtubule associated protein like 4 ( EML4 ) generate a...
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Mesenchymal Stem Cells
Tumor microenvironment (TME) is a complex network with a heterogeneous ensemble of cancer cells, mesenchymal stromal/stem cells (MSCs), inflammatory...