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Cancer Stem Cells (CSCs) in Tumor Ecosystem

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Tumor Ecosystem

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Abstract

In cancer, cancer stem cells (CSCs) is a unique cell population that could acquire the stemness ability of a stem cell that enable them to proliferate and grow exponentially. When seen through the perspective of an ecosystem, many different components of the tumor interact with CSCs, in many different directions. These interactions support the complex changes not only in the local and distal onco-sphere, but also dictates the intra-onco-spherical communications, making both onco-spheres constantly changing to grow in the most suitable environment. According to many studies, different from parental tumor cells, CSCs differ in their gene expression, tumor proliferative capacity, immunological interactions, and responsiveness to treatment. In this chapter, we give an overview of the origin and history of CSCs and their reciprocal crosstalks in the local and distal onco-sphere.

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Authors and Affiliations

  1. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Phei Er Saw & Erwei Song

  2. Nanhai Translational Innovation Center of Precision Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Foshan, China

    Phei Er Saw & Erwei Song

  3. Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Erwei Song

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  1. Phei Er Saw
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  2. Erwei Song
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  1. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Erwei Song

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Saw, P.E., Song, E. (2023). Cancer Stem Cells (CSCs) in Tumor Ecosystem. In: Song, E. (eds) Tumor Ecosystem. Springer, Singapore. https://doi.org/10.1007/978-981-99-1183-7_17

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