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1. Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P

   Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated...

   Yuan-li Ai, Wei-jia Wang, ... Qiao Wu in Cell Research

   Article Open access 17 July 2023
   

2. The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis

   Background

   Aging-related fertility decline is a prevalent concern globally. Male reproductive system aging is mainly characterized by a decrease in...

   Zirun **, Yuzhuo Yang, ... Zhe Zhang in Microbiome

   Article Open access 27 September 2023
   

3. Enterococcus faecalis promotes the progression of colorectal cancer via its metabolite: biliverdin

   Background

   Enterococcus faecalis (Efa) has been shown to be a “driver bacteria” in the occurrence and development of colorectal cancer (CRC). This...

   Li Zhang, **g Liu, ... Yunqing Qiu in Journal of Translational Medicine

   Article Open access 02 February 2023
   

4. Metabolite Effect on Angiogenesis: Insights from Transcriptome Analysis

   Metabolic status of the cells is important in the expression of the angiogenic phenotype in endothelial cells. Our earlier studies demonstrated the...

   P. Sunitha, Kesavan R. Arya, ... Perumana R. Sudhakaran in Cell Biochemistry and Biophysics

   Article 14 June 2022
   

5. Recent advances in GPR35 pharmacology; 5-HIAA serotonin metabolite becomes a ligand

   GPR35, an orphan receptor, has been waiting for its ligand since its cloning in 1998. Many endogenous and exogenous molecules have been suggested to...

   Dong-Soon Im in Archives of Pharmacal Research

   Article 25 May 2023
   

6. Molecular mechanism of valine and its metabolite in improving triglyceride synthesis of porcine intestinal epithelial cells

   An insufficient energy supply to intestinal epithelial cells decreases production performance in weaned piglets. Triglycerides are the main energy...

   Mengmeng Xu, Long Che, ... Zongyong Jiang in Scientific Reports

   Article Open access 20 February 2023
   

7. Encoding Genetic Circuits with DNA Barcodes Paves the Way for High-Throughput Profiling of Dose-Response Curves of Metabolite Biosensors

   Metabolite biosensors, through which the intracellular metabolite concentrations could be converted to changes in gene expression, are widely used in...

   Huibao Feng, Yikang Zhou, Chong Zhang in Synthetic Biology

   Protocol 2024
   

8. Statins affect human iPSC-derived cardiomyocytes by interfering with mitochondrial function and intracellular acidification

   Statins are effective drugs in reducing cardiovascular morbidity and mortality by inhibiting cholesterol synthesis. These effects are primarily...

   Tim Somers, Sailay Siddiqi, ... Tom J. J. Schirris in Basic Research in Cardiology

   Article 02 February 2024
   

9. A cell-free strategy for host-specific profiling of intracellular antibiotic sensitivity and resistance

   Antimicrobial resistance (AMR) is a pandemic spread across multiple infectious disease-causing microbes. To provide a host-specific tool to study...

   Kameshwari Chengan, Charlotte Hind, ... Simon J. Moore in npj Antimicrobials and Resistance

   Article Open access 18 December 2023
   

10. Impact of hypoxia and reoxygenation on the extra/intracellular metabolome and on transporter expression in a human kidney proximal tubular cell line

    Introduction

    Ischemia-reperfusion injury (IRI) induces several perturbations that alter immediate kidney graft function after transplantation and may...

    Quentin Faucher, Stéphanie Chadet, ... Chantal Barin-Le Guellec in Metabolomics

    Article 13 September 2023
    

11. GLP-1 metabolite GLP-1(9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion

    Aims/hypothesis

    Diabetes mellitus is associated with impaired insulin secretion, often aggravated by oversecretion of glucagon. Therapeutic...

    Nikhil R. Gandasi, Rui Gao, ... Patrik Rorsman in Diabetologia

    Article Open access 21 December 2023
    

12. Orientia tsutsugamushi: An Unusual Intracellular Bacteria—Adaptation Strategies, Available Antibiotics, and Alternatives for Treatment

    During evolution Orientia tsutsugamushi became a smarter obligate bacterium to establish as intracellular pathogens. O. tsutsugamushi is a human...

    Prashansha Srivastava, Aishwarya Shukla, ... Dharmendra K. Yadav in Current Microbiology

    Article 21 June 2024
    

13. Ammonium sulfate supplementation enhances erythromycin biosynthesis by augmenting intracellular metabolism and precursor supply in Saccharopolyspora erythraea

    In this study, the cellular metabolic mechanisms regarding ammonium sulfate supplementation on erythromycin production were investigated by employing...

    Yujie Yuan, Feng Xu, ... Ju Chu in Bioprocess and Biosystems Engineering

    Article 01 July 2023
    

14. Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41

    The thermotolerant strain Streptomyces sp. HR41 was found to produce compound 1 only in a 45 °C culture, and not at the standard temperature. We...

    Shun Saito, Shiina Suzuki, Midori A. Arai in The Journal of Antibiotics

    Article 02 August 2022
    

15. Induction of in vitro shoots in Liverwort Acrolejeunea fertilis (Reinw., Blume & Nees) Schiffn. Gametophyte explants and their comparative metabolite and Bioactivity Analysis

    Plant-derived natural products, including those from bryophytes, are particularly advantageous in several aspects, such as for their antifungal,...

    Nadhifa Tazkia Ramadhani, Windri Handayani, ... Afiatry Putrika in Plant Cell, Tissue and Organ Culture (PCTOC)

    Article 26 June 2024
    

16. Ascorbate and Hydrogen Peroxide Modify Metabolite Profile of Wheat Differently

    Effects of ascorbate (ASA) and hydrogen peroxide (H ₂ O ₂ ) on metabolite profile was compared in wheat. Interestingly, the redox environment became more...

    Muhammad Ahsan Asghar, Eszter Balogh, ... Gábor Kocsy in Journal of Plant Growth Regulation

    Article Open access 21 September 2022
    

17. Elicitors: Role in Secondary Metabolite Production in Medicinal Plants

    Elicitors are the stimuli from the living, nonliving, and environmental sources that expedite the synthesis of secondary metabolites in the plants....

    Santhosh B, Phulendra Kumar Bharti, ... Sarita Kumari in Genetic Manipulation of Secondary Metabolites in Medicinal Plant

    Chapter 2023
    

18. IDH1-mutant metabolite D-2-hydroxyglutarate inhibits proliferation and sensitizes glioma to temozolomide via down-regulating ITGB4/PI3K/AKT

    The heterogeneous molecular subtypes of gliomas demonstrate varied responses to chemotherapy and distinct prognostic outcomes. Gliomas with...

    Shuangmei Tong, Jian Wu, ... Bin Wang in Cell Death Discovery

    Article Open access 09 July 2024
    

19. How to Prepare Your Samples for Polar Metabolite Analysis?

    Biological samples such as urine, blood, faeces, cell lysates and tissue are complex matrices containing thousands of small molecules, lipids and...

    Elizabeth Want in A Practical Guide to Metabolomics Applications in Health and Disease

    Chapter 2023
    

20. Metabolite transporters as regulators of macrophage polarization

    Macrophages are myeloid immune cells, present in virtually all tissues which exhibit considerable functional plasticity and diversity. Macrophages...

    **gwen Cheng, Weiwei Cai, ... Fang Wei in Naunyn-Schmiedeberg's Archives of Pharmacology

    Article 01 December 2021