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Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B
The HSP90/CDC37 chaperone system not only assists the maturation of many protein kinases but also maintains their structural integrity after folding....
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The role of m6A methylation in therapy resistance in cancer
Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of therapy resistance is a hot topic in epigenetics. As one of...
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Epigenetics of type 2 diabetes and diabetes-related outcomes in the Strong Heart Study
BackgroundThe prevalence of type 2 diabetes has dramatically increased in the past years. Increasing evidence supports that blood DNA methylation,...
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Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson’s disease
In addition to the well-known degeneration of midbrain dopaminergic neurons, enteric neurons can also be affected in neurodegenerative disorders such...
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Functional characterization of two DYRK1B variants causative of AOMS3
BackgroundTwo new missense variants (K68Q and R252H) of the protein kinase DYRK1B were recently reported to cause a monogenetic form of metabolic...
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p300-mediated acetylation increased the protein stability of HIPK2 and enhanced its tumor suppressor function
Homeodomain-interacting protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase that functions in development and tumor suppression. One of the...
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Programmed Cell Death and its Implications for Skeletal Muscle Wasting
Skeletal muscle atrophy is an inevitable sequel of various factors such as cachexia, aging, fasting, denervation, and microgravity. It is...
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FBXW7 in breast cancer: mechanism of action and therapeutic potential
Breast cancer is one of the frequent tumors that seriously endanger the physical and mental well-being in women. F-box and WD repeat...
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A comprehensive survey into the role of microRNAs in ovarian cancer chemoresistance; an updated overview
Ovarian cancer (OC), a frequent malignant tumor that affects women, is one of the leading causes of cancer-related death in this group of...
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Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics
Exercise training has been widely recognized as a healthy lifestyle as well as an effective non-drug therapeutic strategy for cardiovascular diseases...
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Epigenome-wide association study of bronchopulmonary dysplasia in preterm infants: results from the discovery-BPD program
BackgroundBronchopulmonary dysplasia (BPD) is a lung disease in premature infants caused by therapeutic oxygen supplemental and characterized by...
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Encounter with the Unknown
The severe respiratory syndrome human coronavirus 2 (SARS-CoV-2) pandemic has forced us to recognize the need for rapid analysis of unknown viral...
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PRCC reduces the sensitivity of cancer cells to DNA damage by inhibiting JNK and ATM/ATR pathways and results in a poor prognosis in hepatocellular carcinoma
Background and aimThe proline rich mitotic checkpoint control factor (PRCC) is involved in the splicing process of pre-mRNA. This study aims to...
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Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expression of Cyclin D1 and WEE1, phosphorylates TP53 and reduces cell proliferation in a kinase-dependent manner
Silencing of the Apoptosis associated Tyrosine Kinase gene ( AATK ) has been described in cancer. In our study, we specifically investigated the...
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N-Methyl-D-Aspartate Receptor Signaling-Protein Kinases Crosstalk in Cerebral Ischemia
Although stroke is very often the cause of death worldwide, the burden of ischemic and hemorrhagic stroke varies between regions and over time...
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Acute lymphoblastic leukemia-derived exosome inhibits cytotoxicity of natural killer cells by TGF-β signaling pathway
This study was conducted to explore whether acute lymphoblastic leukemia (ALL)-derived exosomes affect natural killer (NK) cells. Exosomes were...
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DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities
Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to eradicate and inhibit the growth of cancer cells are...
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Atg7 autophagy-independent role on governing neural stem cell fate could be potentially applied for regenerative medicine
A literature review showed that Atg7 biological role was associated with the development and pathogenesis of nervous system, but very few reports...
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miRNA regulation of G protein-coupled receptor mediated angiogenic pathways in cancer
Angiogenesis is an important biological process associated with plethora of physiological and patho-physiological conditions. Recent data suggests...
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Do Carcinogens Have a Threshold Dose? The Pros and Cons
With sound understanding of biological concepts, the notion of threshold effect levels has grown in acceptance especially for electrophile-induced...