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Small volume bone marrow aspirates with high progenitor cell concentrations maximize cell therapy dose manufacture and substantially reduce donor hemoglobin loss
BackgroundBone marrow (BM) transplantation is a life-saving therapy for hematological diseases, and the BM harbors also highly useful (progenitor)...
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Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium
Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid and myeloid lineages. HSPCs are produced in the embryo via...
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MHC class I loss is associated with biliary/progenitor cell features and “cold” tumor-immune microenvironment in hepatocellular carcinoma
Hepatocellular carcinomas (HCCs) with biliary/progenitor cell features frequently show increased programmed death-ligand 1 (PD-L1) expression, but...
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Protection of haematopoietic progenitor cell donors: an updated overview of the European landscape
Haematopoietic progenitor cell donation from bone marrow and mobilised peripheral blood obtained from related and unrelated donors is an established...
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Acetyl-CoA is a key molecule for nephron progenitor cell pool maintenance
Nephron endowment at birth impacts long-term renal and cardiovascular health, and it is contingent on the nephron progenitor cell (NPC) pool....
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Stepwise combined cell transplantation using mesenchymal stem cells and induced pluripotent stem cell-derived motor neuron progenitor cells in spinal cord injury
BackgroundSpinal cord injury (SCI) is an intractable neurological disease in which functions cannot be permanently restored due to nerve damage. Stem...
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Transcriptomics of CD29+/CD44+ cells isolated from hPSC retinal organoids reveals a single cell population with retinal progenitor and Müller glia characteristics
Müller glia play very important and diverse roles in retinal homeostasis and disease. Although much is known of the physiological and morphological...
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Lung development and regeneration: newly defined cell types and progenitor status
The lung is the most critical organ of the respiratory system supporting gas exchange. Constant interaction with the external environment makes the...
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Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size
Cellular competition for limiting hematopoietic factors is a physiologically regulated but poorly understood process. Here, we studied this...
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Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation
Microdeletion of a 3Mb region encompassing 45 protein-coding genes at chromosome 22q11.2 (22q11.2DS) predisposes individuals to multiple...
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In Vitro Generated Equine Hepatic-Like Progenitor Cells as a Novel Potent Cell Pool for Equine Metabolic Syndrome (EMS) Treatment
Equine metabolic syndrome (EMS) is recognized as one of the leading cause of health threatening in veterinary medicine worldwide. Recently, PTP1B...
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Regulation of nephron progenitor cell lifespan and nephron endowment
Low nephron number — resulting, for example, from prematurity or developmental anomalies — is a risk factor for the development of hypertension,...
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Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
Skeletal stem/progenitor cell (SSPC) senescence is a major cause of decreased bone regenerative potential with aging, but the causes of SSPC...
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Decreased progenitor TCF1 + T-cells correlate with COVID-19 disease severity
COVID-19, caused by SARS-CoV-2, can lead to a severe inflammatory disease characterized by significant lymphopenia. However, the underlying cause for...
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Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis
Osteoarthritis (OA) is characterised by an irreversible degeneration of articular cartilage. Here we show that the BMP-antagonist Gremlin 1 ( Grem1 )...
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Recombinant Erythropoietin Induces Oligodendrocyte Progenitor Cell Proliferation After Traumatic Brain Injury and Delayed Hypoxemia
Traumatic brain injury (TBI) can result in axonal loss and demyelination, leading to persistent damage in the white matter. Demyelinated axons are...
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Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis
Wnt signaling is required to maintain bipotent progenitors for neural and paraxial mesoderm cells, the neuromesodermal progenitor (NMP) cells that...
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The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics
The proliferation and differentiation of hepatic progenitor cells (HPCs) drive the homeostatic renewal of the liver under diverse conditions. Liver...
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The Endometrial Stem/Progenitor Cells and Their Niches
Endometrial stem/progenitor cells are a type of stem cells with the ability to self-renew and differentiate into multiple cell types. They exist in...
