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Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps
Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, we identify and chemically optimize...
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Evaluation of the inhibitory effect of isopulegol (ISO) and its β-cyclodextrin inclusion complex (ISO/β-CD) on the reversal of Staphylococcus aureus efflux pump activity
Staphylococcus aureus is known to be a human pathogen and is often resistant to antibiotics, so there is a demand for new treatment alternatives that...
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AcrAB efflux pump impacts on the survival of adherent-invasive Escherichia coli strain LF82 inside macrophages
The tripartite complex AcrAB-TolC is the major RND pump in Escherichia coli and other Enterobacteriaceae. It consists of the AcrB transporter, which...
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An efflux pump in genomic island GI-M202a mediates the transfer of polymyxin B resistance in Pandoraea pnomenusa M202
BackgroundPolymyxin B is considered a last-line therapeutic option against multidrug-resistant gram-negative bacteria, especially in COVID-19...
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The frequency of efflux pump genes expression in Acinetobacter baumannii isolates from pulmonary secretions
Acinetobacter baumannii is an important opportunistic pathogen, and the cause of nosocomial infections worldwide in recent decades. Efflux pumps are...
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Efflux pump inhibitors: new updates
AbstractThe discovery of antibiotics ought to have ended the issue of bacterial infections, but this was not the case as it has led to the evolution...
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Abrogation of efflux pump activity, biofilm formation, and immune escape by candidacidal geraniol in emerging superbug, Candida auris
During the last decade, Candida auris emerged as a threatening human fungal pathogen that notably caused outbreaks around the globe with high...
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Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition
The Resistance-Nodulation-Division (RND) efflux pump superfamily is pervasive among Gram-negative pathogens and contributes extensively to clinical...
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The Putative Major Facilitator Superfamily (MFS) Protein Named Rv1877 in Mycobacterium tuberculosis Behaves as a Multidrug Efflux Pump
Efflux pumps are one of the major contributors in the intrinsic multidrug resistance of Mycobacterium tuberculosis . These active transporters,...
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A genetic platform to investigate the functions of bacterial drug efflux pumps
Efflux pumps are a serious challenge for the development of antibacterial agents. Overcoming efflux requires an in-depth understanding of efflux pump...
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The Role of Efflux Pumps in Antibiotic Resistance of Gram Negative Rods
Antibiotic resistance is an important public health problem today, causing increased morbidity and mortality. Resistance to antibiotics in bacteria...
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Evaluation of Bcr/cflA Targeted Efflux Inhibitory Potential of 2-Hydroxy-4-Methoxybenzaldehyde Against Proteus mirabilis
Amidst the challenge posed by multiple drug-resistant (MDR) bacteria, this study investigates the efficacy of 2-Hydroxy-4-methoxybenzaldehyde (HMB)...
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Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus
Membrane protein efflux pumps confer antibiotic resistance by extruding structurally distinct compounds and lowering their intracellular...
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Synthesis and Evaluation of Antimicrobial Activities of Gold and ZnO Nanoparticles on Inhibiting the MexAB-OprM Efflux Pump in Pseudomonas aeruginosa Isolates
One of the problems in treating burn patients is the emergence of antibiotic resistance with various mechanisms. Mex pumps play a significant role in...
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A robust fluorescence-based assay for human erythrocyte Ca++ efflux suitable for high-throughput inhibitor screens
Intracellular calcium is maintained at very low concentrations through the action of PMCA Ca ++ extrusion pumps. Although much of our knowledge about...
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Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein
Membrane efflux pumps play a major role in bacterial multidrug resistance. The tripartite multidrug efflux pump system from Escherichia coli ,...
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Role of bacterial multidrug efflux pumps during infection
Multidrug efflux pumps are protein complexes located in the cell envelope that enable bacteria to expel, not only antibiotics, but also a wide array...
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Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae
OqxB is an RND (Resistance-Nodulation-Division) efflux pump that has emerged as a factor contributing to the antibiotic resistance in Klebsiella...
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Effect of Carvacrol and Thymol on NorA efflux pump inhibition in multidrug-resistant (MDR) Staphylococcus aureus strains
Undue exposure to antimicrobials has led to the acquisition and development of sophisticated bacterial resistance mechanisms, such as efflux pumps,...
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Luteolin increases susceptibility to macrolides by inhibiting MsrA efflux pump in Trueperella pyogenes
Trueperella pyogenes ( T. pyogenes ) is an opportunistic pathogen associated with a variety of diseases in many domestic animals. Therapeutic treatment...
