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Exploring the inhibitors for competitive AI software development through cloud driven transformation
COVID-19 has compelled every sector to shift towards virtualizing, and to curb the spread of this deadly virus, technologies like cloud computing,...
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Thyroid disorders induced by immune checkpoint inhibitors
Immune checkpoint inhibitors (ICIs) are a revolutionary class of drugs that powerfully contribute to cancer therapy by harnessing the immune system...
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The trend of dental check-up and prevalence of dental complications following the use of bone modifying agents in patients with metastatic breast and prostate cancer: analysis of data from the Korean National Health Insurance Service
BackgroundBone-modifying agents (BMA) are key components in the management of cancer patients with bone metastasis. Despite their clinical benefits,...
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Identification of a family of species-selective complex I inhibitors as potential anthelmintics
Soil-transmitted helminths (STHs) are major pathogens infecting over a billion people. There are few classes of anthelmintics and there is an urgent...
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Inhibitors application time and pasture canopy capture regulate gaseous losses of urine-N
Technologies have been developed for the in-situ treatment of urine patches deposited by grazing livestock to mitigate nitrogen (N) losses using N...
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Decoding the conundrum: exploring complex interlinkages between mobile wallet adoption inhibitors among unorganised retailers
The success of mobile wallet (m-wallet) in develo** countries depends upon a great extent to its adoption among unorganised retailers. The adoption...
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Exploring isoindolin-1-ones as potential CDK7 inhibitors using cheminformatic tools
In women who die from cancer, breast cancer is the most common cause of death. The development of small molecular scaffolds as specific...
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JAK inhibitors improve ATP production and mitochondrial function in rheumatoid arthritis: a pilot study
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated by inflammation of the synovial tissue and autoantibody production....
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Pre-activation of hypoxia-inducible factor 1-α using prolyl hydroxylase domain inhibitors reduces cisplatin-induced nephrotoxicity
Cisplatin is a widely used, highly effective chemotherapy drug that has a critical nephrotoxic side effect associated with acute kidney injury....
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An Enzymatic Activity Assay for Heparanase That Is Useful for Evaluating Clinically Relevant Inhibitors and Studying Kinetics
The enzyme heparanase cleaves heparan sulfate and is involved in a range of human diseases including cancer, inflammation, diabetes, and viral...
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A novel compound to overcome influenza drug resistance in endonuclease inhibitors
Influenza is a seasonal respiratory illness that kills hundreds of thousands of people every year. Currently, neuraminidase inhibitors and...
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Ketones: the double-edged sword of SGLT2 inhibitors?
Sodium–glucose cotransporter 2 (SGLT2) inhibitors are a class of medications used by individuals with type 2 diabetes that reduce hyperglycaemia by...
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Identification of inhibitors targeting the energy-coupling factor (ECF) transporters
The energy-coupling factor (ECF) transporters are a family of transmembrane proteins involved in the uptake of vitamins in a wide range of bacteria....
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Potential role of cyclin-dependent kinase 4/6 inhibitors in the treatment of mucosal melanoma
Mucosal melanoma (MM) is a rare and aggressive form of melanoma with a poorer prognosis compared to other subtypes. Recent large-scale...
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Binding mechanism and biological effects of flavone DYRK1A inhibitors for the design of new antidiabetics
The selective inhibition of kinases from the diabetic kinome is known to promote the regeneration of beta cells and provide an opportunity for the...
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Assessment of structural and activity-related contributions of various PIM-1 kinase inhibitors in the treatment of leukemia and prostate cancer
One of the most perilous illnesses in the world is cancer. The cancer may be associated with the mutation of different genes inside the body. The PIM...
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Evaluation of Small-Molecule HDAC Inhibitors Through In Vitro and In Cellulo Approaches
The aberrant activity of histone deacetylases (HDACs) across a broad range of cancers and other disease indications has led to the development of...
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Recent Trends in the Development of Corrosion Inhibitors
The inhibition of aqueous corrosion of metals and alloys is a challenging research area attracting attention from scientists and engineers from...
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Tumor immune checkpoints and their associated inhibitors
Immunological evasion is one of the defining characteristics of cancers, as the immune modification of an immune checkpoint (IC) confers immune...