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A roadmap for ribosome assembly in human mitochondria
Mitochondria contain dedicated ribosomes (mitoribosomes), which synthesize the mitochondrial-encoded core components of the oxidative phosphorylation...
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Resolving chaperone-assisted protein folding on the ribosome at the peptide level
Protein folding in vivo begins during synthesis on the ribosome and is modulated by molecular chaperones that engage the nascent polypeptide. How...
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From a focal skin issue to a systemic disease: the multifaceted nature of cold sores, novel findings
Cold sores, a viral infection caused by the herpes simplex virus, are a prevalent affliction affecting millions of people across the globe. In this...
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Nucleoside and non-nucleoside reverse transcriptase inhibitor drugs (NRTIs and NNRTIs) are capable of binding Chandipura virus polymerase protein (L) and inhibit virus replication
Chandipura virus (CHPV) is an emerging pathogen of Indian subcontinent. It is a vector borne virus and belongs to Rhabdovirus family. In recent past...
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Genome sequencing of SARS-Co-V-2 reveals mutations including F559I and V781D in S protein and LI123-124L in the nsp6 in 21K and 21L clades
Contagious and virulent virus variants like B.1.1.529 have complicated the 2019 global COVID-19 pandemic from Wuhan, China. Omicron, with extensive...
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VCP/p97-associated proteins are binders and debranching enzymes of K48–K63-branched ubiquitin chains
Branched ubiquitin (Ub) chains constitute a sizable fraction of Ub polymers in human cells. Despite their abundance, our understanding of branched Ub...
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cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers
The canonical BRG/BRM-associated factor (cBAF) complex is essential for chromatin opening at enhancers in mammalian cells. However, the nature of the...
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Sewage surveillance of SARS-CoV-2 in Tokyo (May 2020–June 2022): method using high-throughput, fully-automated platform
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is shed in saliva, sputum, and feces of the novel coronavirus disease 2019 (COVID-19)...
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Structural basis of MALAT1 RNA maturation and mascRNA biogenesis
The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) long noncoding RNA (lncRNA) has key roles in regulating transcription, splicing,...
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Single-base tiled screen unveils design principles of PspCas13b for potent and off-target-free RNA silencing
The development of precise RNA-editing tools is essential for the advancement of RNA therapeutics. CRISPR (clustered regularly interspaced short...
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Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly
The mitochondrial chaperonin, mitochondrial heat shock protein 60 (mtHsp60), promotes the folding of newly imported and transiently misfolded...
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In situ analysis of neuronal injury and neuroinflammation during HIV-1 infection
BackgroundSince the introduction of combination antiretroviral therapy (cART) the brain has become an important human immunodeficiency virus (HIV)...
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Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy
During formation of the transcription-competent open complex (RPo) by bacterial RNA polymerases (RNAPs), transient intermediates pile up before...
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Kinetics of dengue viremia and its association with disease severity: an ambispective study
BackgroundDengue virus (DENV) infection is an important public health problem and causes significant morbidity and mortality. DENV typically causes a...
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Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD
Mitophagy preserves overall mitochondrial fitness by selectively targeting damaged mitochondria for degradation. The regulatory mechanisms that...
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Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
Epigenetic regulators have a crucial effect on gene expression based on their manipulation of histone modifications. Histone H2AK119...
