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Real-World Treatment Patterns and Clinical Outcomes Among Patients with Metastatic or Unresectable EGFR-Mutated Non-Small Cell Lung Cancer Previously Treated with Osimertinib and Platinum-Based Chemotherapy
IntroductionFor patients with epidermal growth factor receptor-mutated ( EGFR m) locally advanced/metastatic non-small cell lung cancer (mNSCLC) whose...
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Cost Offset of Dapagliflozin in the US Medicare Population with Cardio-Kidney Metabolic Syndrome
IntroductionCardiovascular-kidney-metabolic (CKM) syndrome is highly prevalent in the US Medicare population and is projected to increase further....
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Ectonucleotidase inhibitors: targeting signaling pathways for therapeutic advancement—an in-depth review
Ectonucleotidase inhibitors are a family of pharmacological drugs that, by selectively targeting ectonucleotidases, are essential in altering...
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Biomarkers to predict efficacy of immune checkpoint inhibitors in colorectal cancer patients: a systematic review and meta-analysis
Immune checkpoint inhibitors (ICIs) are approved to treat colorectal cancer (CRC) with mismatch-repair gene deficiency, but the response rate remains...
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The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside
Despite being characterized by high malignancy, high morbidity, and low survival rates, the underlying mechanism of hepatocellular carcinoma (HCC)...
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Eteplirsen Treatment for Duchenne Muscular Dystrophy: A Qualitative Patient Experience Study
IntroductionDuchenne muscular dystrophy (DMD) is characterized by rapid functional decline. Current available treatment options aim to delay disease...
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The predictors of fungal infections after liver transplantation and the influence of fungal infections on outcomes
The primary objective of this study was to assess the incidence, timing, risk factors of fungal infections (FIs) within 3 months after liver...
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Early change of plasma Epstein-Barr virus DNA load and the viral lytic genome level could positively predict clinical outcome in recurrent or metastatic nasopharyngeal carcinoma receiving anti-programmed cell death 1 monotherapy
PurposePatients with recurrent or metastatic nasopharyngeal carcinoma (RM-NPC) have proven benefit from anti-programmed cell death 1 (anti-PD-1)...
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Sedation-free pediatric [18F]FDG imaging on totalbody PET/CT with the assistance of artificial intelligence
PurposeWhile sedation is routinely used in pediatric PET examinations to preserve diagnostic quality, it may result in side effects and may affect...
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A unified metric of human immune health
Immunological health has been challenging to characterize but could be defined as the absence of immune pathology. While shared features of some...
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Cancer cost-related subjective financial distress among breast cancer: a sco** review
PurposeThis article provided a comprehensive sco** review, synthesizing existing literature on the financial distress faced by breast cancer...
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Radiomics and visual analysis for predicting success of transplantation of heterotopic glioblastoma in mice with MRI
BackgroundQuantifying tumor growth and treatment response noninvasively poses a challenge to all experimental tumor models. The aim of our study was,...
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Cancer-related cognitive impairment in older adults with acute myeloid leukemia treated with hypomethylating agents and venetoclax chemotherapy: a longitudinal descriptive study
PurposeTo explore cancer-related cognitive impairment (CRCI) in older adults with acute myeloid leukemia (AML) receiving venetoclax in combination...
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Efficacy of a nurse-led sexual rehabilitation intervention for women with gynaecological cancers receiving radiotherapy: results of a randomised trial
BackgroundThe multicentre randomised SPARC trial evaluated the efficacy of a nurse-led sexual rehabilitation intervention on sexual functioning,...
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DNA ploidy and PTEN as biomarkers for predicting aggressive disease in prostate cancer patients under active surveillance
BackgroundCurrent risk stratification tools for prostate cancer patients under active surveillance (AS) may inadequately identify those needing...
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Laparoscopic Total Pancreatectomy After Laparoscopic Whipple
BackgroundThe incidence of a second de novo pancreatic ductal adenocarcinoma (PDAC) among patients with prior cancer has been reported to be 6%.
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R2-ISS staging combined with circulating plasma cells improves risk stratification for newly diagnosed multiple myeloma: a single-center real-world study
We aimed to evaluate if circulating plasma cells (CPC) detected by flow cytometry could add prognostic value of R2-ISS staging. We collected the...
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SEOM-GG clinical guidelines for the management of germ-cell testicular cancer (2023)
Testicular germ cell tumors are the most common tumors in adolescent and young men. They are curable malignancies that should be treated with...