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Effect of Hepatic Impairment on Trofinetide Exposures Using an In Silico Physiologically Based Pharmacokinetic Model
IntroductionTrofinetide is the first drug to be approved for the treatment of Rett syndrome. Hepatic impairment is not expected to affect the...
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3D airway geometry analysis of factors in airway navigation failure for lung nodules
BackgroundThis study aimed to quantitatively reveal contributing factors to airway navigation failure during radial probe endobronchial ultrasound...
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Post-COVID syndrome prevalence: a systematic review and meta-analysis
BackgroundSince the Coronavirus disease 2019 (COVID-19) pandemic began, the number of individuals recovering from COVID-19 infection have increased....
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Embedding community and public voices in co-created solutions to mitigate antimicrobial resistance (AMR) in Thailand using the ‘Responsive Dialogues’ public engagement framework
The use of antimicrobials in Thailand has been reported as one of the highest in the world in human and animal sectors. Our engagement project aimed...
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Lasso-Cox interpretable model of AFP-negative hepatocellular carcinoma
BackgroundIn AFP-negative hepatocellular carcinoma patients, markers for predicting tumor progression or prognosis are limited. Therefore, our...
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Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE−/− mice
Aortic aneurysm is characterized by a pathological dilation at specific predilection sites of the vessel and potentially results in life-threatening...
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Joint association of sedentary time and physical activity with abnormal heart rate recovery in young and middle-aged adults
BackgroundAbnormal heart rate recovery (HRR), representing cardiac autonomic dysfunction, is an important predictor of cardiovascular disease....
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Respective contribution of baseline clinical data, tumour metabolism and tumour blood-flow in predicting pCR after neoadjuvant chemotherapy in HER2 and Triple Negative breast cancer
Background :The aim of this study is to investigate the added value of combining tumour blood flow (BF) and metabolism parameters, including texture...
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Extension of efficacy range for targeted malaria-elimination interventions due to spillover effects
Malaria-elimination interventions aim to extinguish hotspots and prevent transmission to nearby areas. Here, we re-analyzed a cluster-randomized...
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Direct observation of translational activation by a ribonucleoprotein granule
Biomolecular condensates organize biochemical processes at the subcellular level and can provide spatiotemporal regulation within a cell. Among...
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CAR-T cell therapy in AML: recent progress and future perspectives
Despite several small-molecule drugs that have revolutionized the current treatment strategy for acute myeloid leukemia (AML), hematopoietic stem...
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Gender-based violence and harassment at work and health and occupational outcomes. A systematic review of prospective studies
BackgroundMany people experience forms of gender-based violence and harassment (GBVH) in the context of their work. This includes a wide range of...
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Timing of Breast Cancer Related Lymphedema Development Over 3 Years: Observations from a Large, Prospective Randomized Screening Trial Comparing Bioimpedance Spectroscopy (BIS) Versus Tape Measure
BackgroundThe PREVENT randomized control trial monitored progression to chronic breast cancer-related lymphedema (cBCRL) following intervention for...
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Rearrangements involving 11q23.3/KMT2A in adult AML: mutational landscape and prognostic implications – a HARMONY study
Balanced rearrangements involving the KMT2A gene ( KMT2A r) are recurrent genetic abnormalities in acute myeloid leukemia (AML), but there is lack of...
