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Common and rare variants in genetic susceptibility analysis of mature B-cell neoplasm subtypes by whole exome sequencing

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Fig. 1: Genetic susceptibility and heritability of mature B-cell neoplasms (MBNs) in common and rare variants.
Fig. 2: Genetic and other factors predict risk for mature B-cell neoplasm (MBN) subtypes.

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Acknowledgements

This research has been conducted using the UK Biobank Resource under Application Number 107825. We want to acknowledge the participants and investigators of the UK Biobank and FinnGen study. We thank **jie Fan and Tao Chen for their help and advice in this study.

Funding

This study is supported by the Science and Technology Program of Guangzhou (2023A03J0540, 2024A03J0750), and National Natural Science Foundation of China (82302104).

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Author notes

  1. These authors contributed equally: Junwei Lin, Maoting Shen.

Authors and Affiliations

  1. Guangzhou KingMed Transformative Medicine Institute Co. Ltd, Guangzhou, China

    Junwei Lin, Maoting Shen & Yuhuan Meng

  2. KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China

    Junwei Lin, Maoting Shen, Shihui Yu & Yuhuan Meng

  3. Guangzhou Kingmylab Pharmaceutical Research Co. Ltd, Guangzhou, China

    Wenjuan **ao

  4. Guangzhou KingMed Diagnostics Group Co. Ltd, Guangzhou, China

    Yuxin Chen & Shihui Yu

Authors
  1. Junwei Lin
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  2. Maoting Shen
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  3. Wenjuan **ao
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  4. Yuxin Chen
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  5. Shihui Yu
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  6. Yuhuan Meng
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Contributions

YM conceptualized the study; YM, JL, MS, and WX performed the data analysis; YM, JL, and MS wrote the manuscript with input from all authors; YC and SY revised the manuscript; all authors read and approved the final version of the manuscript.

Corresponding author

Correspondence to Yuhuan Meng.

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Lin, J., Shen, M., **ao, W. et al. Common and rare variants in genetic susceptibility analysis of mature B-cell neoplasm subtypes by whole exome sequencing. Leukemia (2024). https://doi.org/10.1038/s41375-024-02332-5

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