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Musk Fragrances and Environmental Fate Models – HHCB as an Example for Model Refinements
The theory of environmental fate and distribution models is briefly introduced. Afterwards, by means of the models laid down in the European Union...
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Bioaccumulation and Ecotoxicity of Synthetic Musks in the Aquatic Environment
Due to the fact that both nitro and polycyclic musk fragrances and their metabolites are not readily biodegradable in most sewage treatment plants...
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Recent Studies Conducted by the Research Institute for Fragrance Materials (RIFM) in Support of the Environmental Risk Assessment Process
Although the environmental risk assessments for the nitro musks, musk ketone and musk xylene, and the polycyclic musks, AHTN and HHCB, showed that...
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Toxicology of Synthetic Musk Compounds in Man and Animals
Synthetic musk compounds (musk fragrances) are chemically heterogeneous compounds. The available toxicological data are incomplete. The NOAEL (No...
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Synthetic Musks in the Aquatic System of Berlin as an Example for Urban Ecosystems
This chapter compiles some data on the occurrence and fate of synthetic musk compounds in the aquatic environment of Berlin, Germany. The city of...
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Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward a multimodal mechanism of action?
Neurodegenerative diseases and brain tumours represent important health challenges due to their severe nature and debilitating consequences that...
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DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2
DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed in lymphoid and myeloid lineage cells. It interacts with...
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TOTEM: a multi-cancer detection and localization approach using circulating tumor DNA methylation markers
BackgroundDetection of cancer and identification of tumor origin at an early stage improve the survival and prognosis of patients. Herein, we...
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Controllable self-cleaning FET self-assembled RNA-cleaving DNAzyme based DNA nanotree for culture-free Staphylococcus aureus detection
Staphylococcus aureus (SA) poses a serious risk to human and animal health, necessitating a low-cost and high-performance analytical platform for...
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Map** alternative splicing events in colorectal cancer
Although aberrant splicing events of genes are closely related to the development and progression of colorectal cancer (CRC), the map** of abnormal...
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A Ratiometric Benzimidazole-Based Fluorescent Probe for The Recognition of Phosgene in Solution and Gaseous Phases
Considering the high toxicity and widespread application of phosgene, there is an urgent need to develop a simple and sensitive method for detecting...
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Nonadherence to oral cancer chemotherapy in hepatocellular carcinoma: prevalence and predictive factors in Vietnam
PurposeStandard oral cancer chemotherapy (OCT) or targeted therapy (OTT) has expanded the treatment methods for hepatocellular carcinoma (HCC)....
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A multidisciplinary group-based survivorship intervention for those living with multiple myeloma: a feasibility study
BackgroundWhile multiple myeloma continues to be an incurable cancer, advances in its understanding and management have led to significantly improved...
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Effects of high-intensity interval training on cardiometabolic biomarkers in patients with prostate cancer undergoing active surveillance: a randomized controlled trial
PurposeTo report the effects of a 12-week high-intensity interval training (HIIT) program on cardiometabolic biomarkers in patients with prostate...
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Breast cancer preventive practices and associated factors among reproductive age women in Wadila District, North East Ethiopia: community based cross-sectional study
BackgroundCancer is one of the leading causes of morbidity and mortality worldwide. Among all cancer types, breast cancer stands out as the most...
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White matter microstructural integrity as a key to effective propagation of gamma entrainment in humans
Gamma entrainment through sensory stimulation has the potential to reduce the pathology of Alzheimer’s disease in mouse models. However, clinical...
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Gene therapy by virus-like self-spooling toroidal DNA condensates for revascularization of hindlimb ischemia
Peripheral arterial diseases (PAD) have been reported to be the leading cause for limb amputations, and the current therapeutic strategies including...
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Impact on Glycemia Risk Index and other metrics in type 1 adult patients switching to Advanced Hybrid Closed-Loop systems: a one-year real-life experience
BackgroundAdvanced Hybrid Closed-Loop system (AHCL) has profoundly changed type 1 diabetes therapy. This study primarily aimed to assess the impact...
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