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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive...
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Systematic Review on Flow Cytometry as a Versatile Tool for Disease Diagnosis
Purpose of ReviewQuantification and identification of cell fate remain to be the most important step within research and diagnostic laboratories.With...
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Engaging Mood Brain Circuits with Psilocybin (EMBRACE): a study protocol for a randomized, placebo-controlled and delayed-start, neuroimaging trial in depression
BackgroundMajor depressive disorder (MDD) is a leading cause of disability worldwide across domains of health and cognition, affecting overall...
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Harnessing the Power of Immunotherapy in Liver Transplantation for HCC
Purpose of ReviewHCC is a leading cause of cancer-related mortality in chronic liver disease patients. Liver transplant is a potential curative...
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Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer
Mismatch repair (MMR)-deficient cancer evolves through the stepwise erosion of coding homopolymers in target genes. Curiously, the MMR genes MutS...
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Multi-scale modeling to investigate the effects of transcranial magnetic stimulation on morphologically-realistic neuron with depression
Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique to activate or inhibit the activity of neurons, and thereby...
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Can photoperiod improve growth performance and antioxidant responses of pacu (Piaractus mesopotamicus) reared in recirculation aquaculture systems?
The present study investigated the best photoperiod for culturing pacu ( Piaractus mesopotamicus ) in recirculation aquaculture systems (RAS) based on...
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Identification of purinergic system components in the venom of Bothrops mattogrossensis and the inhibitory effect of specioside extracted from Tabebuia aurea
Snake bites are a severe problem in the countryside of Brazil and are usually attributed to snakes of the genera Bothrops, Crotalus , and Lachesis ....
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In-Vitro Study of the Binding of Atorvastatin with Adenine using Multi-Spectroscopic Approaches
Atorvastatin—an oral lipid regulating drug is a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), which...
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Central nervous system-associated macrophages modulate the immune response following stroke in aged mice
Age is a major nonmodifiable risk factor for ischemic stroke. Central nervous system-associated macrophages (CAMs) are resident immune cells located...
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App-based telerehabilitation program for older adults on waiting list for physiotherapy after hospital discharge: a feasibility pragmatic randomized trial
BackgroundInactivity while waiting for outpatient physiotherapy worsens the physical deconditioning of older adults after hospital discharge....
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Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease
APOE4 is the strongest genetic risk factor for Alzheimer’s disease (AD), with increased odds ratios in female carriers. Targeting amyloid plaques...
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Building genomic capacity for precision health in Africa
The African continent is poised to have a pivotal role in the global population landscape, with the United Nations projecting a population of 2.5...
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Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction
BackgroundThe function of polymorphonuclear neutrophils (PMNs) decreases with age, which results in infectious and inflammatory complications in...
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Breaking barriers: sha** global health futures with pilot and feasibility initiative
In the dynamic landscape of global health, the journey from a new development to its implementation is often fraught with challenges. Yet, it is...
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KLK7 expression in human tumors: a tissue microarray study on 13,447 tumors
BackgroundKallikrein-related peptidase 7 (KLK7) is a chymotrypsin-like serine protease which is essential for the desquamation of corneocytes and...
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A holistic lifestyle mobile health intervention for the prevention of type 2 diabetes and common mental disorders in Asian women with a history of gestational diabetes: a randomised control trial with 3-year follow-up protocol
BackgroundWomen with a history of gestational diabetes mellitus (GDM) are 12-fold more likely to develop type 2 diabetes (T2D) 4–6 years after...
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Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice
Despite intense efforts to develop efficient therapeutic regimes for asthma, there is a large demand for novel treatment strategies in this disease....
