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Transmissible long-term neuroprotective and pro-cognitive effects of 1–42 beta-amyloid with A2T icelandic mutation in an Alzheimer’s disease mouse model
The amyloid cascade hypothesis assumes that the development of Alzheimer’s disease (AD) is driven by a self-perpetuating cycle, in which β-amyloid...
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Extinction training suppresses activity of fear memory ensembles across the hippocampus and alters transcriptomes of fear-encoding cells
Contextual fear conditioning has been shown to activate a set of “fear ensemble” cells in the hippocampal dentate gyrus (DG) whose reactivation is...
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Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility
Impaired behavioural flexibility is a core feature of neuropsychiatric disorders and is associated with underlying dysfunction of fronto-striatal...
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Shared and unique alterations of large-scale network connectivity in drug-free adolescent-onset and adult-onset major depressive disorder
Differences in clinical manifestations and biological underpinnings between Major Depressive Disorder (MDD) onset during adolescence and adulthood...
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Decoding the inflammatory signature of the major depressive episode: insights from peripheral immunophenoty** in active and remitted condition, a case–control study
Depression is a prevalent and incapacitating condition with a significant impact on global morbidity and mortality. Although the immune system’s role...
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The role of sexual self-esteem, sexual desire, and sexual assertiveness in the female sexual function
BackgroundSexual function plays a very important role in the sexual health of people, and the determination of their related factors reflects the...
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Neuropsychobiology of fear-induced bradycardia in humans: progress and pitfalls
In the last century, the paradigm of fear conditioning has greatly evolved in a variety of scientific fields. The techniques, protocols, and analysis...
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Differential methylation of OPRK1 in borderline personality disorder is associated with childhood trauma
According to a growing body of neurobiological evidence, the core symptoms of borderline personality disorder (BPD) may be linked to an opioidergic...
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Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations
Coffee is one of the most widely consumed beverages. We performed a genome-wide association study ( GWAS ) of coffee intake in US-based 23andMe...
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Neural mechanisms of psychedelic visual imagery
Visual alterations under classic psychedelics can include rich phenomenological accounts of eyes-closed imagery. Preclinical evidence suggests...
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Comprehensive analysis of genetic risk loci uncovers novel candidate genes and pathways in the comorbidity between depression and Alzheimer’s disease
There is growing evidence of a shared pathogenesis between Alzheimer’s disease and depression. Therefore, we aimed to further investigate their...
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Genetics of child aggression, a systematic review
Excessive and persistent aggressiveness is the most common behavioral problem that leads to psychiatric referrals among children. While half of the...
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A mobile device-based game prototype for ADHD: development and preliminary feasibility testing
This research aimed to devise and assess a mobile game therapy software for children with Attention-Deficit/Hyperactivity Disorder (ADHD), as well as...
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Pharmacological modulation of developmental and synaptic phenotypes in human SHANK3 deficient stem cell-derived neuronal models
Phelan-McDermid syndrome (PMDS) arises from mutations in the terminal region of chromosome 22q13, impacting the SHANK3 gene. The resulting deficiency...
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A meta-analysis of the effects of ketamine on suicidal ideation in depression patients
The treatment of suicidal ideation in patients with depression has been a major problem faced by psychiatric and emergency departments, and...
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Hippocampal transcriptome-wide association study and pathway analysis of mitochondrial solute carriers in Alzheimer’s disease
The etiopathogenesis of late-onset Alzheimer’s disease (AD) is increasingly recognized as the result of the combination of the aging process, toxic...
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Improving the efficacy and effectiveness of evidence-based psychosocial interventions for attention-deficit/hyperactivity disorder (ADHD) in children and adolescents
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent, chronic, and impairing mental health disorder of childhood. Decades of empirical...
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Depression and risk of infectious diseases: A mendelian randomization study
Previous observational inquiries have revealed a correlation between depression and infectious maladies. This study seeks to elucidate the causal...
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Association of post-COVID phenotypic manifestations with new-onset psychiatric disease
Acute COVID-19 infection can be followed by diverse clinical manifestations referred to as Post Acute Sequelae of SARS-CoV2 Infection (PASC). Studies...
